Stress, coping, and alcohol use in young adulthood
In this study, we examined whether perceived level of stress moderated the association between drinking coping motives and alcohol use in a community sample of young adult men. Data came from alcohol users who were interviewed at mean age 26 (N = 344) and again at mean age 29 (N = 333). (Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Helene R. White, Kristen G. Anderson, Jordan Beardslee Source Type: research
The acute alcohol transcriptome parallels that of rapid antidepressants
Alcohol and depression display a strong comorbidity, and it is thought that self-medication with alcohol often occurs in depressed individuals. We aim to identify synaptic changes that are common to both alcohol and antidepressants to elucidate the molecular basis of the self-medication hypothesis. We found that acute alcohol exposure alters the function of the GABABR in hippocampal dendrites that leads to increased dendritic calcium signaling and downstream activation of translation (Wolfe et al., Nat. (Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Authors: S.A. Wolfe, C.F. Heaney, F. Niere, S.P. Farris, R.D. Mayfield, R.A. Harris, K.F. Raab-Graham Source Type: research
Histone methylation involvement in lasting memory deficits and ethanol sensitivity after binge ethanol in adolescents
Alcohol use in teens primarily occurs in binges and is associated with cognitive impairments, reduced white matter content, and synaptic pruning in the frontal cortex. Binge drinking in adolescence increases the rewarding aspects of ethanol while decreasing its aversive properties, enabling higher consumption and risk for alcohol use disorders. Indeed, drinking at an early age increases risk for adult dependence. Ongoing brain development, particularly regarding prefrontal cortex (PFC) myelination and synaptic connectivity, may make adolescent drinkers highly vulnerable to lasting consequences of binge ethanol. (Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Jennifer T. Wolstenholme Source Type: research
The role of the Periaqueductal Gray Area in maladaptive emotional and behavioral responses stemming from alcohol dependence
Adaptations in key brain regions developed over the course of alcohol dependence perpetuate the disorder by inducing negative affective states that drive compensatory, compulsory alcohol drinking. The Periaqueductal Gray Area (PAG) is a midbrain region that coordinates emotional and behavioral responses to aversive stimuli through connections with the extended amygdala, a cluster of coordinated regions that modulate alcohol dependence-related emotional and behavioral phenotypes. Here, we assess the contribution of two key PAG subregions, the dorsal and ventral PAG, to emotional and behavioral changes stemming from alcohol ...
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Emily Lowery-Gionta, Huiling Wang, Leandro Vendruscolo, Dylan Sucich, Brendan Tunstall, Lisa Thomas, Marisela Morales, George F. Koob Source Type: research
Withdrawal from chronic intermittent ethanol engages a circuit in the bed nucleus of the stria terminalis that promotes anxiety and fear-related behavior
Alcohol dependence is a progressive brain disorder characterized by an increased sensitivity to the reinforcing properties of alcohol, compulsive and habitual use, and chronic relapse to alcohol drinking. Earlier studies from our lab have shown that acute withdrawal from chronic intermittent ethanol (CIE) vapor enhances anxiety-like behavior and serotonin2C (5-HT2CR) signaling in the BNST. In a more recent study, we found that 5-HT2CR signaling elicits anxiety and fear-related behavior by activating an inhibitory microcircuit in the BNST. (Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Catherine A. Marcinkiewcz, Dipanwita Pati, Jeffrey F. Diberto, Thomas L. Kash Source Type: research
Consequences of continuous social defeat stress on ethanol-induced corticosterone responses and brain monoamines
Introduction: Chronic exposure to stress may dysregulate the hypothalamic-pituitary-adrenal axis and brain monoamines, contributing to the development of stress-related disorders, including drug and alcohol dependence. The present study assessed ethanol-induced corticosterone responses and brain monoamine levels in mice previously submitted to continuous social defeat stress. Methodology: Male Swiss mice were exposed to a 10-day continuous social defeat protocol, with daily confrontations with an aggressive male resident. (Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Isabel M. Hartmann-Quadros, Cristiane A. Favoretto, Yasmin C. Nunes, Giovana C. Macedo Source Type: research
Author Index
(Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Source Type: research
Young alcohol binge drinkers show immune/inflammatory alterations with higher susceptibility in women: Correlations with neuropsychological abilities
Alcohol binge drinking is a pattern of heavy alcohol consumption increasingly used by adolescents and young adults. Evidence indicates that alcohol binge induces peripheral inflammation and an exacerbated neuroimmune response that may participate in the alcohol-induced cognitive/behavioral dysfunctions. Here, we recruited 20 years old university students, identified as men and women binge drinkers for at least 2 years. Young alcohol binge drinkers had elevated levels of blood endotoxin compared with controls and an up-regulation of TLR4/NF κB inflammatory pathway in peripheral blood mononuclear cells, together with pro-in...
Source: Alcohol - May 1, 2017 Category: Addiction Authors: Laura Or ío, María Antón, Inmaculada Concepción Rodríguez-Rojo, Ángeles Correas, Borja García-Bueno, Monserrat Corral, Fernando Rodríguez de Fonseca, Luis Miguel García-Moreno, Fernando Maestú, Fernando Cadaveira Source Type: research
Editorial Board
(Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Source Type: research
Table of Contents
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Source: Alcohol - May 1, 2017 Category: Addiction Source Type: research
Instructions to Authors
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Source: Alcohol - May 1, 2017 Category: Addiction Source Type: research
Volterra Cover - Use the uploaded file after incoporating the changes. Use only Outside front cover
(Source: Alcohol)
Source: Alcohol - May 1, 2017 Category: Addiction Source Type: research
α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption
Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system have been implicated in ethanol behaviors. In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption and sedation. A limitation of these studies is that the alteration in the receptor was present throughout development. The recently described α6β2 antagonist, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI), now makes it possible to test for the involvement of these receptors using a pharmacological approach. (Source: Alcohol)
Source: Alcohol - April 27, 2017 Category: Addiction Authors: Helen M. Kamens, Colette Peck, Caitlin Garrity, Alex Gechlik, Brenita C. Jenkins, Akshat Rajan Source Type: research
Working memory over a six-year period in young binge drinkers
The objective of this study was to analyze the relationship between BD trajectory and WM in university students. (Source: Alcohol)
Source: Alcohol - April 20, 2017 Category: Addiction Authors: C. Carbia, F. Cadaveira, E. L ópez-Caneda, F. Caamaño-Isorna, S. Rodríguez Holguín, M. Corral Source Type: research
Effects of acute alcohol intoxication on executive functions controlling self-regulated behavior
Alcohol consumption may lead to deficits in the executive functions that govern self-regulation. These deficits could lead to risk-taking behaviors; therefore, it is important to determine the magnitude of these deficits on executive functioning. The purpose of this experiment was to investigate the acute effects of alcohol on three of the executive functions that are hypothesized to affect self-regulation, which are inhibition, set shifting, and working memory, using a mixed-methods study design. (Source: Alcohol)
Source: Alcohol - April 19, 2017 Category: Addiction Authors: Suzanne Spinola, Stephen A. Maisto, Corey N. White, Tani Huddleson Source Type: research
