Consequences of continuous social defeat stress on ethanol-induced corticosterone responses and brain monoamines

Introduction: Chronic exposure to stress may dysregulate the hypothalamic-pituitary-adrenal axis and brain monoamines, contributing to the development of stress-related disorders, including drug and alcohol dependence. The present study assessed ethanol-induced corticosterone responses and brain monoamine levels in mice previously submitted to continuous social defeat stress. Methodology: Male Swiss mice were exposed to a 10-day continuous social defeat protocol, with daily confrontations with an aggressive male resident.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Isabel M. Hartmann-Quadros, Cristiane A. Favoretto, Yasmin C. Nunes, Giovana C. Macedo Source Type: research