The acute alcohol transcriptome parallels that of rapid antidepressants

Alcohol and depression display a strong comorbidity, and it is thought that self-medication with alcohol often occurs in depressed individuals. We aim to identify synaptic changes that are common to both alcohol and antidepressants to elucidate the molecular basis of the self-medication hypothesis. We found that acute alcohol exposure alters the function of the GABABR in hippocampal dendrites that leads to increased dendritic calcium signaling and downstream activation of translation (Wolfe et al., Nat.
Source: Alcohol - Category: Addiction Authors: Source Type: research