Reply by Authors
Our report and others suggest that certain patients with muscle invasive bladder cancer can avoid or defer radical cystectomy following a clinical complete response to neoadjuvant platinum based chemotherapy. Although we observed favorable outcomes in this highly select group of patients, there are several limitations and points of caution that must be acknowledged, as the comments highlight. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Tags: Adult Urology Source Type: research
Reply by Author
A recent publication in The Journal demonstrated the opposite findings and showed poor quality of life in patients performing intermittent self-dilation.1 Patients experience pain and discomfort, and have difficulty with urethral self-dilation. They are referred or self-refer to a specialist to discuss surgical options to avoid intermittent catheterization. This finding certainly holds true in my reconstructive practice. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Tags: Letter to the Editor/Errata Source Type: research
Single nucleotide polymorphisms of HAAO and IRX 6 genes as risk factors for hypospadias
We evaluated the association of hypospadias with 17 susceptibility loci previously identified by a European genome-wide association study (GWAS) in Japanese patients. We also examined the expression of candidate genes in male mouse embryos to discuss the possible underlying mechanisms of this disease. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Authors: Yoshiyuki Kojima, Tomoyuki Koguchi, Kentaro Mizuno, Yuichi Sato, Seiji Hoshi, Junya Hata, Hidenori Nishio, Daiki Hashimoto, Shoko Matsushita, Kentaro Suzuki, Shinichi Miyagawa, Chi Chung Hui, Chizu Tanikawa, Yoshimori Murakami, Gen Yamada, Yutaro Hayashi, Source Type: research
Predicting Gleason Group Progression for Men on Prostate Cancer Active Surveillance: The Role of a Negative Confirmatory MRI-US Fusion Biopsy
Active surveillance (AS) has gained acceptance as an alternative to definitive therapy for many men with prostate cancer (PCa). Confirmatory biopsies to assess the appropriateness of AS are routinely performed and negative biopsies are regarded as a favorable prognostic indicator. Our study sought to determine the prognostic implications of negative multi-parametric magnetic resonance imaging (mpMRI)-transrectal ultrasound (TRUS) guided fusion biopsy (FB) consisting of extended sextant, systematic biopsy (SB) plus mpMRI-guided targeted biopsy of suspicious MRI lesions. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Authors: Jonathan B. Bloom, Graham Hale, Samuel A. Gold, Kareem Rayn, Clayton Smith, Sherif Mehralivand, Marcin Czarniecki, Vladimir Valera, Bradford J. Wood, Maria Merino, Peter L. Choyke, Howard L. Parnes, Baris Turkbey, Peter A. Pinto Source Type: research
Gender Equivalence in the Prevalence of Nephrolithiasis among Adults Younger than 50 Years in the United States
Although urolithiasis affects each gender, conventional teaching proposes that men are 3 times more likely to have stones. However, clinical practice refutes such a disparity, particularly among working age adults. Small studies have suggested an erosion of this gender gap. Therefore, we examined the relationship between gender and stone prevalence among American adults younger than 50 years. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Gina Tundo, Sari Khaleel, Vernon M. Pais Tags: Adult Urology Source Type: research
Gender Equivalence in the Prevalence of Nephrolithiasis among Adults Younger than 50 Years Old in the United States
Although urolithiasis affects each gender, conventional teaching proposes that men are 3 times more likely to have stones. However, clinical practice refutes such a disparity, particularly among working age adults. Small studies have suggested an erosion of this gender gap. Therefore, we examined the relationship between gender and stone prevalence among American adults younger than 50 years. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Gina Tundo, Sari Khaleel, Vernon M. Pais Tags: Adult Urology Source Type: research
Conversion from Cystine to Noncystine Stones: Incidence and Associated Factors
Patients with cystinuria are often treated with medical alkalinization and shock wave lithotripsy, although each treatment is hypothesized to increase the risk of calcium phosphate stones. We performed a multicenter retrospective review to evaluate whether stones of another composition develop in patients with cystinuria and with what frequency. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Lael Reinstatler, Karen Stern, Hunt Batter, Kymora B. Scotland, Gholamreza Safaee Ardekani, Marcelino Rivera, Ben H. Chew, Brian Eisner, Amy E. Krambeck, Manoj Monga, Vernon M. Pais Tags: Adult Urology Source Type: research
Re: The Effect of Nerve Sparing Status on Sexual and Urinary Function: 3-Year Results from the CEASAR Study
Avulova et al have performed a noteworthy study assessing the true impact of nerve sparing (NS) on the long-term functional outcomes of radical prostatectomy (RP). Walsh et al described the basic technique of NS RP more than 30 years ago.1 A multitude of studies have subsequently displayed functional improv ements to potency and urinary continence (UC) with NS vs non-NS RP.2–4 Yet the effect of NS recently has been called into question.5,6 (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Venkat M. Ramakrishnan, Karolin Bossert, Kurt H. Lehmann, Lukas J. Hefermehl Tags: Letter to the Editor/Errata Source Type: research
Editorial Comment
The authors provide a retrospective review of a large, prospectively managed database of patients with metastatic renal cell carcinoma in South Korea who received a first line tyrosine kinase inhibitor. In this cohort of more than 1,000 patients the authors found that conditional survival improved with time after initial treatment with the tyrosine kinase inhibitor. This trend was mostly driven by patients with Heng poor risk disease. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Adam B. Weiner Tags: Adult Urology Source Type: research
A contemporary analysis of dual inflatable penile prosthesis and artificial urinary sphincters outcomes
Inflatable penile prostheses (IPP) and artificial urinary sphincters (AUS) are used to treat men with erectile dysfunction (ED) and stress urinary incontinence (SUI), respectively. After treatment of prostate cancer, men often experience ED and SUI. Dual prosthetic implantation can improve the quality of life of these men. We evaluated the reoperation outcomes in men who underwent dual implantation compared to each individually. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Neal Patel, Ron Golan, Joshua A. Halpern, Tianyi Sun, Abena Denise Asafu-Adjei, Bilal Chughtai, Peter Stahl, Art Sedrakyan, James A. Kashanian Source Type: research
Conversion from Cystine to Non-cystine Stones: Incidence and Associated Factors
and Objectives: Cystinuric patients are often treated with medical alkanalization and shockwave lithotripsy – both are hypothesized to increase the risk of calcium phosphate stones. We performed a multi-center retrospective review to evaluate whether patients with cystinuria develop stones of other composition and with what frequency. (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Lael Reinstatler, Karen Stern, Hunt Batter, Kymora B. Scotland, Gholamreza Safaee Ardekani, Marcelino Rivera, Ben H. Chew, Brian Eisner, Amy E. Krambeck, Manoj Monga, Vernon M. Pais Source Type: research
Gender Equivalence in Prevalence of Nephrolithiasis among Adults under 50 Years of Age in the United States
Although urolithiasis affects both sexes, conventional teaching proposes that men are 3x more likely to suffer from stones. Clinical practice however refutes such disparity, particularly among working-aged adults. Small studies have suggested an erosion of this gender gap. We therefore sought to examine the relationship between gender and stone prevalence among U.S. adults (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Gina Tundo, Sari Khaleel, Vernon M. Pais Source Type: research
Evaluation of Cancer-Specific Mortality with Surgery Versus Radiation as Primary Therapy for Localized High-Grade Prostate Cancer in Men Younger than 60 Years Old
The objective of this project was to compare the impact of initial radical prostatectomy versus radiation therapy on survival outcomes for young men (Source: The Journal of Urology)
Source: The Journal of Urology - July 27, 2018 Category: Urology & Nephrology Authors: Hubert Huang, Stefano Muscatelli, Michael Naslund, Shahed N. Badiyan, Adeel Kaiser, Mohummad Minhaj Siddiqui Source Type: research
Editorial Comment
“Winds of change” blow for prostate cancer diagnostics. Recently published data from the PRECISION (Prostate Evaluation for Clinically Important Disease: Sampling Using Image guidance or Not?) trial clearly emphasize the role of targeted biopsies over systematic biopsies (reference 1 in article) . Some are ready to rely on MRI and discard routine systematic biopsies while some are more hesitant and still consider systematic biopsies essential. (Source: The Journal of Urology)
Source: The Journal of Urology - July 26, 2018 Category: Urology & Nephrology Authors: Antti Rannikko Tags: Adult Urology Source Type: research
Editorial Comment
The authors report the prospective implementation of an ERAS protocol for children undergoing urinary tract reconstruction with small bowel. In this small-scale study 15 patients treated after implementation of an ERAS protocol had shorter time to flatus, stool and discharge home compared to 15 patients treated before intervention. Although adult focused ERAS protocols have been described for various abdominal surgeries,1,2 this study reveals that an ERAS protocol can be successfully used in children despite the variability in physiology, social factors and evidence strength in the 2 populations. (Source: The Journal of Urology)
Source: The Journal of Urology - July 26, 2018 Category: Urology & Nephrology Authors: Kathleen Kieran Tags: Pediatric Urology Source Type: research
