HBV epidemiology and genetic diversity in an area of high prevalence of hepatitis B in southern Brazil
ConclusionsThese results demonstrate a pivotal role of intrafamilial transmission for HBV spreading in this population. Furthermore, there is a high prevalence of HBV genotype D in this region. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - August 7, 2018 Category: Infectious Diseases Source Type: research

Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
Publication date: Available online 6 August 2018Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Regina Gayoso, Margareth Dalcolmo, José Ueleres Braga, Draurio Barreira (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - August 6, 2018 Category: Infectious Diseases Source Type: research

Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
ConclusionThis study suggests that the CT genotype of the IL1B –31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 24, 2018 Category: Infectious Diseases Source Type: research

Effectiveness of chronic hepatitis C treatment with direct-acting antivirals in the Public Health System in Brazil
ConclusionThe treatment of chronic HCV infection for genotypes 1, 2 or 3 with the therapeutic regimens established by the Brazilian guidelines showed high rates of SVR, even in cirrhotic patients. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 21, 2018 Category: Infectious Diseases Source Type: research

Microbiology and clinical characteristics of viridans group streptococci in patients with cancer
This study assessed the microbiology, clinical syndromes, and outcomes of oncologic patients with viridans group streptococci (VGS) isolated from blood cultures between January 1st, 2013 and December 31st, 2016 in a referral hospital in Mexico using the Bruker MALDI Biotyper. Antimicrobial sensitivity was determined using BD Phoenix 100 according to CLSI M100 standards. Clinical information was obtained from medical records and descriptive analysis was performed.Forty-three patients were included, 22 females and 21 males, aged 42 ± 17 years. Twenty (46.5%) patients had hematological cancer and 23 (53.5%) a solid malig...
Source: The Brazilian Journal of Infectious Diseases - July 18, 2018 Category: Infectious Diseases Source Type: research

Schistosomal liver fibrosis and hepatocellular carcinoma – case series of patients submitted to liver transplantation
Publication date: Available online 12 July 2018Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Norma Arteiro Filgueira, Camilla Maria de Alencar Saraiva, Norma Thomé Jucá, Matheus Filgueira Bezerra, Claudio Moura LacerdaAbstractSchistosomiasis affects approximately 207 million people in 76 countries. The association between hepatocellular carcinoma (HCC) and Schistosoma mansoni infection (SMI) has been investigated. Studies using animal models suggest that the parasite may accelerate the oncogenic process when combined with other factors, such as hepatitis C virus infection or exposure to a carcinogen. Her...
Source: The Brazilian Journal of Infectious Diseases - July 12, 2018 Category: Infectious Diseases Source Type: research

Galactomannan use in clinical practice: providing free testing is not the full answer
ConclusionThe correct use of galactomannan testing is essential for an early diagnosis of invasive aspergillosis, which may improve the prognosis of the disease. We demonstrated that clinicians usually ask for galactomannan tests to confirm imaging findings in patients who frequently were on antifungal drugs, something that could be improved by medical education. We observed a low frequency of galactomannan use for preemptive antifungal therapy (25.7%), which is worrying considering the well-known beneficial use of GM testing in this scenario. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Zoonotic spillover and emerging viral diseases – time to intensify zoonoses surveillance in Brazil
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Joel Henrique Ellwanger, José Artur Bogo Chies (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Is it time for Brazil to prioritize TB preventive therapy for all people living with HIV?
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Ethel L. Maciel, Thiago N. do Prado, Kleydson Bonfim Andrade, Jonathan E. Golub (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

First case of Furuncular Myiasis due to Cordylobia anthropophaga in a Latin American resident returning from Central African Republic
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Jóse A. Suárez, Argentina Ying, Luis A. Orillac, Israel Cedeño, Néstor SosaAbstractMyiasis is a temporary infection of the skin or other organs with fly larvae.1 The larvae develop into boil-like lesions. Creeping sensations and pain are usually described by patients. Following the maturation of the larvae, spontaneous exiting and healing is experienced. Herein we present a case of a traveler returning from Central African Republic. She does not recall insect bites. She never took off her clothing...
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Fernando Rosso, Juan C. Pineda, Ana M. Sanz, Jorge A. Cedano, Luis A. CaicedoAbstractDengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients h...
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Bacteremia due to Moraxella osloensis: a case report and literature review
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Yuta Maruyama, Tomonari Shigemura, Koki Aoyama, Noriyuki Nagano, Yozo NakazawaAbstractHerein we report the case of a 10-year-old boy with an autosomal mosaic mutation who developed bacteremia. The causative agent was identified as Moraxella osloensis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. In the pediatric population, there have been 13 case reports of infection attributed to M. osloensis and this is the fifth reported case of pedia...
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Methicillin-resistant Staphylococcus aureus isolated from an intensive care unit in Minas Gerais, Brazil, over a six-year period
Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Thiago C. Nascimento, Cláudio G. Diniz, Vânia L. Silva, Alessandra B. Ferreira-Machado, Marina O. Fajardo, Tamara Lopes R. de Oliveira, Dennis de C. Ferreira, Fernanda S. Cavalcante, Kátia R. Netto dos SantosAbstractTo characterize methicillin-resistant Staphylococcus aureus isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 isolates were recovered from patients admitted to the intensive care unit in the study period. Resistance rates hig...
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections
In conclusion, treatment with non-original fluconazole under usual medical practice conditions results in appropriate blood and cerebrospinal fluid levels of the drug for inhibiting Cryptococcus spp. susceptible to this antifungal drug. The relatively common failures of neurocryptococcosis treatment appear not to be due to insufficient fluconazole levels in the cerebrospinal fluid, especially with the use of daily doses of 400–800 mg. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research

Isolation of blaNDM-producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil
This study describes two microorganisms producers of the New Delhi Metallo-b-lactamase, Klebsiella pneumoniae and Citrobacter freundii, from two patients admitted to a public hospital in Salvador, Bahia. These are the first clinical cases of New Delhi Metallo-b-lactamase described in microorganisms in the north and northeast Brazil. The isolates were characterized by antimicrobial susceptibility test, with resistance to all β-lactams including carbapenems, negative Modified Hodge Test and the synergy test with Ethylenediaminetetraacetic acid, Phenylboronic Acid and Cloxacillin was positive only with Ethylenediaminetetraac...
Source: The Brazilian Journal of Infectious Diseases - July 10, 2018 Category: Infectious Diseases Source Type: research