Development and validation of a simple and rapid way to generate low volume of plasma to be used in point-of-care HIV virus load technologies
Publication date: Available online 21 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Isabelle Vasconcellos, Diana Mariani, Marcelo C.V.M. de Azevedo, Orlando C. Ferreira, Amilcar TanuriAbstractA new point-of-care (POC) HIV virus load (VL), mPIMA HIV-1/2 VL, Abbott, USA, has been recently developed. This POC VL requires no skilled person to run and uses a small plasma volume (50 μL). However, obtaining 50 μL of plasma can be a challenge in limited resource settings. We validated a simple and easy method to obtain enough amount of plasma to run a POC VL. The study utilized 149 specime...
Source: The Brazilian Journal of Infectious Diseases - November 22, 2019 Category: Infectious Diseases Source Type: research

Treatment of chronic hepatitis C in patients with chronic kidney disease with Sofosbuvir-basead regimes
ConclusionSofosbuvir-based regimens are effective to treat HCV in patients with CKD. In patients with mild CKD this type of therapy seems to be safe. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 22, 2019 Category: Infectious Diseases Source Type: research

Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
Publication date: Available online 21 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Gilma Sánchez-Burgos, Carla Herrera-Nájera, Roberto Cedillo-Rivera, Eric DumonteilAbstractThe antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison w...
Source: The Brazilian Journal of Infectious Diseases - November 22, 2019 Category: Infectious Diseases Source Type: research

Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis
ConclusionsThe results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 19, 2019 Category: Infectious Diseases Source Type: research

FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis
Publication date: Available online 16 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Renan Barros Domingues, Márcio Vega dos Santos, Fernando Brunale Vilela de Moura Leite, Carlos SenneAbstractThe precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Therefore, other methods for rapid and accurate diagnosis of central nervous system infections are required. FilmArray meningitis/encephalitis (ME) panel is a P...
Source: The Brazilian Journal of Infectious Diseases - November 16, 2019 Category: Infectious Diseases Source Type: research

Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review
ConclusionP. laurentii infection in humans is usually associated to neoplasia and multiple co-morbidities, and amphotericin B seems to be a reliable agent for treatment. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 16, 2019 Category: Infectious Diseases Source Type: research

A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers
Publication date: Available online 16 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Fabianne Carlesse, Liane Esteves Daudt, Adriana Seber, Álvaro Pimenta Dutra, Analy Salles de Azevedo Melo, Belinda Simões, Carla Macedo, Carmem Bonfimi, Eliana Benites, Lauro Gregianin, Marjorie Vieira Batista, Marcelo Abramczyk, Vivian Tostes, Henrique Lederman, Maria Lúcia de Martino Lee, Sandra Logetto, Cláudio Galvão, Arnaldo Lopes ColomboAbstractIn the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed th...
Source: The Brazilian Journal of Infectious Diseases - November 16, 2019 Category: Infectious Diseases Source Type: research

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China
Publication date: Available online 14 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Ting Zhao, Zhixu Ye, Binlin Wang, Yuxia Cui, Yingjie Nie, Bin Yang, Kun Chen, Hua Zhang, Hu Fangfang, Yu FuxunAbstractTo investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou Provincial People's Hospital, from December 2017 to March 2018, and inoculated to Hep-2 cells to isolate HRSV. Cells that showed cytopathic effect (C...
Source: The Brazilian Journal of Infectious Diseases - November 14, 2019 Category: Infectious Diseases Source Type: research

Ghost tablets mimicking intestinal parasite
Publication date: Available online 14 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Lorena Porte, Thomas Weitzel (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 14, 2019 Category: Infectious Diseases Source Type: research

Hepatitis B viremia in HIV-coinfected individuals under antiretroviral therapy
ConclusionsDespite being on ART, a significant proportion of HIV/HBV-coinfected individuals present HBV viremia. Characterization of factors that are associated with this finding may help professionals provide better management to these patients. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 10, 2019 Category: Infectious Diseases Source Type: research

Prevalence and molecular analysis of multidrug-resistant Acinetobacter baumannii in the extra-hospital environment in Mthatha, South Africa
ConclusionExtra-hospital sources such as abattoir and aquatic environments may be a vehicle of spread of MDR A. baumannii strains in the community and hospital settings. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 8, 2019 Category: Infectious Diseases Source Type: research

Infectivity of Simulium damnosum s.l. and therapeutic coverage of ivermectin distribution 10 years post treatment around Owena Dam, Ondo state, Nigeria
ConclusionDespite the years of treatment of onchocerciasis in Owena community, there were still some infective flies capable of transmitting O. volvolus. This could be due to the low rate of therapeutic coverage as a result of non-compliance in the community for various reasons earlier stated. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 5, 2019 Category: Infectious Diseases Source Type: research

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 AND GST
ConclusionPatients with theCYP2E1 variant genotype or Null GSTT1 showed higher risk of presenting DILI (p = 0.09; OR: 4.57; 95% CI: 0.75–27.6). Individuals with both genotypes had no increased risk compared to individuals with one genotype. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 5, 2019 Category: Infectious Diseases Source Type: research

The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study
ConclusionsIran has successfully combined hepatitis B vaccination into regular immunization programs. The WHO goal of reducing HBsAg prevalence to an equivalent of 1% by 2020 has been reached. With respect to vaccination effectiveness and low prevalence of the disease in the country, catch-up hepatitis B vaccination programs for adolescents can guarantee the immunity of the population. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - November 1, 2019 Category: Infectious Diseases Source Type: research

Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population
Publication date: Available online 18 October 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Changyuan Wang, Li Wei, Weilin Chu, Haiyang Yu, Xinjuan Yu, Chunxia LiAbstractHost immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexu...
Source: The Brazilian Journal of Infectious Diseases - October 19, 2019 Category: Infectious Diseases Source Type: research