Methicillin-resistant Staphylococcus aureus isolated from an intensive care unit in Minas Gerais, Brazil, over a six-year period

Publication date: January–February 2018Source: The Brazilian Journal of Infectious Diseases, Volume 22, Issue 1Author(s): Thiago C. Nascimento, Cláudio G. Diniz, Vânia L. Silva, Alessandra B. Ferreira-Machado, Marina O. Fajardo, Tamara Lopes R. de Oliveira, Dennis de C. Ferreira, Fernanda S. Cavalcante, Kátia R. Netto dos SantosAbstractTo characterize methicillin-resistant Staphylococcus aureus isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 isolates were recovered from patients admitted to the intensive care unit in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97.7%), rifampin (88.8%), and gentamycin (86.6%). The SCCmec typing revealed that the isolates harbored the types III (66.7%), II (17.8%), IV (4.4%), and I (2.2%). Four (8.9%) isolates carried non-typeable cassettes. Most (66.7%) of the isolates were related to the Brazilian endemic clone from CC8/SCCmec III, which was prevalent (89.3%) between 2005 and 2007, while the USA100/CC5/SCCmec II lineage emerged in 2007 and was more frequent in the last few years. The study showed high rates of antimicrobial resistance among methicillin-resistant S. aureus isolates and the replacement of Brazilian clone, a well-established hospital lineage, by the USA100 in the late 2000s, at the intensive care unit under study.
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research