Everything old is new again: New developments in prolotherapy
Prolotherapy, or fibroproliferative therapy, is a regenerative injection therapy, first popularized in the 1940s and 1950s. Unfortunately, the combination of “better” surgical techniques and a series of high-profile medical catastrophes by poorly trained providers relegated the technique into the “fringe” arena. However, recent recognition of the failure of surgical interventions, combined with better technology and a burgeoning interest in the c ontinuum of regenerative injection options, has renewed the interest and research into this “old” technique. (Source: Techniques in Regional Anesthesia and Pain Management)
Source: Techniques in Regional Anesthesia and Pain Management - November 14, 2016 Category: Anesthesiology Authors: Andrea Trescot Source Type: research

Platelet-rich plasma injections for lumbar discogenic pain: A preliminary assessment of structural and functional changes
The goal of this case review is to evaluate functional and structural changes with the use of intradiscal PRP in patients with lumbar discogenic pain. The secondary outcomes include improvement in pain, medication use, hospitalization, and surgery. Low back pain affects a large portion of the population causing a major social and economic effect. Current interventional treatments remain inadequate and transient targeting the symptoms without addressing the underlying cause. Platelet-rich plasma (PRP) has been used clinically in various settings for its healing properties attributed to growth factors. (Source: Techniques in...
Source: Techniques in Regional Anesthesia and Pain Management - November 14, 2016 Category: Anesthesiology Authors: Annu Navani, Alexandra Hames Source Type: research

Role of intra-articular platelet-rich plasma in sacroiliac joint pain
The goal of this case review is to evaluate safety and efficacy with the use of intra-articular platelet-rich plasma (PRP) in patients with sacroiliac (SI) joint (SIJ) pain. The secondary outcomes include additional medical treatments, hospitalization, and surgery. SIJ pain contributes significantly to the social and economic burden due to its long-standing and debilitating course. Current treatments include either interventional procedures with transient benefits or invasive surgical options. PRP has been used clinically in various settings for its anti-inflammatory and tissue repair properties attributed to growth factor...
Source: Techniques in Regional Anesthesia and Pain Management - November 14, 2016 Category: Anesthesiology Authors: Annu Navani, Deepak Gupta Source Type: research

Platelet-rich plasma injections for knee osteoarthritis: Systematic review of duration of clinical benefit
Both researchers and clinicians have exhibited growing interest in the use of platelet-rich plasma (PRP) and other autologous products for a variety of clinical conditions. Newly published data suggest that PRP injections can be an effective complement to conventional management strategies for knee osteoarthritis (OA) and chondropathy. Using a systematic review approach, we sought to synthesize the published data on the duration of clinical effect of PRP on knee OA and chondropathy. We systematically searched PubMed for all reports published in any language between the earliest available date and July (fourth week) of 2015...
Source: Techniques in Regional Anesthesia and Pain Management - November 14, 2016 Category: Anesthesiology Authors: Dmitri Souzdalnitski, Samer N. Narouze, Imanuel R. Lerman, Aaron Calodney Source Type: research

Peripheral nerve entrapment, hydrodissection, and neural regenerative strategies
Peripheral nerve entrapments are an underrecognized cause of pain and disability. Hydrodissection (perineural deep injections) is one of the techniques that can release the entrapped nerve. Futhermore, discussed are the techniques of neural therapy, neural prolotherapy (perineural injection therapy), and autologous platelet lysate, as well as the use of adipose-derived stem cells. (Source: Techniques in Regional Anesthesia and Pain Management)
Source: Techniques in Regional Anesthesia and Pain Management - November 14, 2016 Category: Anesthesiology Authors: Andrea Trescot, Michael Brown Source Type: research

Regenerative medicine injection techniques for the hip pathology
Hip pain is a common complaint that can have both intra-articular and extra-articular origins. Three common causes of hip pain are hip osteoarthritis, iliopsoas tendinopathy, and gluteus medius tendinopathy. Current treatment plans range from conservative measures to surgical replacement. Traditionally, minimally invasive approaches with the use of corticosteroid and local anesthetic injections have served to manage symptoms of pain without altering disease progression. In addition, these agents have been associated with deleterious effects on bone, tendon, and cartilage health. (Source: Techniques in Regional Anesthesia and Pain Management)
Source: Techniques in Regional Anesthesia and Pain Management - November 13, 2016 Category: Anesthesiology Authors: Neil Mandalaywala, George C. Chang Chien, Enrique Galang, Prin X. Amorapanth, Kenneth D. Candido Source Type: research

Safety of stromal vascular fraction cells applications in chronic pain
Autologous stromal vascular fraction (SVF) can be enzymatically released from lipoaspirate obtained under local anesthesia. SVF is known to have regenerative, anti-inflammatory, pain mitigating, and immune-modulatory properties. Our translational research network has been studying the safety and efficacy of SVF since 2012. Almost 100 related physician teams around the world are applying the same institutional review board –approved methods of SVF production, which use a surgically closed SVF isolation system. (Source: Techniques in Regional Anesthesia and Pain Management)
Source: Techniques in Regional Anesthesia and Pain Management - November 10, 2016 Category: Anesthesiology Authors: Elliot B. Lander, Mark H. Berman, Jackie R. See Source Type: research

Regenerative medicine techniques in the management of chronic tendinopathy
Tendinopathy is characterized by failure of the normal tendon repair mechanism, and is a common malady that leads to chronic pain. Although pain relief is an important goal in treating the patient with tendinopathy, modalities that are intended to decrease pain in the short term do not address the underlying tissue disorder. As no current gold standard exists in the treatment of tendinopathy, physicians face a unique challenge in treating this common pathology. Regenerative medicine applications in pain medicine aim to address this unique challenge. (Source: Techniques in Regional Anesthesia and Pain Management)
Source: Techniques in Regional Anesthesia and Pain Management - November 10, 2016 Category: Anesthesiology Authors: Enrique Galang, George C. Chang Chien, Agnes Stogicza, Andrea Trescot Source Type: research

Ultrasound-guided regional anesthesia simulation and trainee performance
The objective of this study was to measureand record trainee performance during an ultrasound-guided femoral nerve block (FNB) with a novel high fidelity feedback based simulator device. The method decribes a novel phantom simulator that was built, capable of objectively recording trainee performance and providing visual and audio feedback on the completion of a successful FNB. Overall, 33 subjects were comprised of medical students and residents performed 2 separate ultrasound simulation sessions, and were placed in 1 of 3 groups: light emitting diode and piezoelectric buzzer feedback (LED and PBZ), voice feedback alone, ...
Source: Techniques in Regional Anesthesia and Pain Management - November 25, 2015 Category: Anesthesiology Authors: Imanuel R. Lerman, Dmitri Souzdalnitski, Thomas Halaszynski, Feng Dai, Maged Guirguis, Samer N. Narouze Source Type: research

High-frequency peripheral electric nerve block to treat postamputation pain
Postamputation residual limb pain is often a disabling chronic pain condition. Oftentimes, patients are left with a chronic stump pain that is refractory to current pain management modalities, such as medications, peripheral nerve blocks or denervation techniques, nerve or spinal cord stimulation, or surgical revision. Using high-frequency alternating current via a peripheral nerve cuff electrode creates a complete depolarizing nerve block, which blocks painful or unwanted nerve transmission of pain signals; the cuff is placed proximal to the neuroma at the end of the severed nerve. (Source: Techniques in Regional Anesthes...
Source: Techniques in Regional Anesthesia and Pain Management - November 25, 2015 Category: Anesthesiology Authors: Amol Soin, Zi-Ping Fang, Jon Velasco, Nemeth Shah, Maged Guirguis, Mena Mekhail Source Type: research

Ultrasound-guided regional anesthesia simulation and trainee performance
The objective of this study was to measureand record trainee performance during an ultrasound-guided femoral nerve block (FNB) with a novel high fidelity feedback based simulator device. The method decribes a novel phantom simulator that was built, capable of objectively recording trainee performance and providing visual and audio feedback on the completion of a successful FNB. Overall, 33 subjects were comprised of medical students and residents performed 2 separate ultrasound simulation sessions, and were placed in 1 of 3 groups: light emitting diode and piezoelectric buzzer feedback (LED and PBZ), voice feedback alone, ...
Source: Techniques in Regional Anesthesia and Pain Management - November 24, 2015 Category: Anesthesiology Authors: Imanuel R. Lerman, Dmitri Souzdalnitski, Thomas Halaszynski, Feng Dai, Maged Guirguis, Samer N. Narouze Source Type: research

High-frequency peripheral electric nerve block to treat postamputation pain
Postamputation residual limb pain is often a disabling chronic pain condition. Oftentimes, patients are left with a chronic stump pain that is refractory to current pain management modalities, such as medications, peripheral nerve blocks or denervation techniques, nerve or spinal cord stimulation, or surgical revision. Using high-frequency alternating current via a peripheral nerve cuff electrode creates a complete depolarizing nerve block, which blocks painful or unwanted nerve transmission of pain signals; the cuff is placed proximal to the neuroma at the end of the severed nerve. (Source: Techniques in Regional Anesthes...
Source: Techniques in Regional Anesthesia and Pain Management - November 24, 2015 Category: Anesthesiology Authors: Amol Soin, Zi-Ping Fang, Jon Velasco, Nemeth Shah, Maged Guirguis, Mena Mekhail Source Type: research

The role of peripheral nerve block analgesia in advancing therapeutic effectiveness spanning the episode of care
Health care reform has brought an unprecedented emphasis on attaining greater value for patients from treatment managed by individual providers and health care facilities. The value is defined as the relationship of the outcome achieved over an episode of care compared to the effort and resources employed to achieve this outcome. It is delivered when patients recover faster with fewer expensive resources, such as hospital, skilled nursing, or rehab facility stays. It is assessed by considering longer episodes of care, such as 30-180 days after performance of a procedure; and by assessing functional recovery, independence, ...
Source: Techniques in Regional Anesthesia and Pain Management - November 23, 2015 Category: Anesthesiology Authors: Armin Schubert, Maged Guirguis Source Type: research

The adductor canal catheter and interspace between the popliteal artery and the posterior capsule of the knee for total knee arthroplasty
Analgesia for total knee arthroplasty (TKA) is not a new topic; however, some newer approaches to peripheral nerve blocks for control of postoperative pain have been developed. The femoral nerve block plus or minus a sciatic nerve block has been shown to provide effective analgesia, but not without some degree of motor block. The adductor canal block provides analgesia not inferior to a femoral with less motor weakness, and a continuous catheter technique can be used to prolong its effects. Blocking the sciatic nerve has been a subject of controversy, in part because of the motor weakness but also because of the inclusion ...
Source: Techniques in Regional Anesthesia and Pain Management - November 20, 2015 Category: Anesthesiology Authors: Clint E. Elliott, Salman Thobhani Source Type: research