Pediatric pancreas transplantation, including total pancreatectomy with islet autotransplantation
Unlike other solid organ transplants, whole pancreas transplantation in children is relatively rare, and it occurs more frequently in the context of multivisceral or composite organ transplantation. Because children only infrequently suffer severe sequelae of type I diabetes mellitus, pancreas transplantation is rarely indicated in the pediatric population. More commonly, pediatric pancreas transplant occurs in the setting of incapacitating acute recurrent or chronic pancreatitis, specifically islet autotransplantation after total pancreatectomy. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Alexander J. Bondoc, Maisam Abu-El-Haija, Jaimie D. Nathan Source Type: research
Pediatric lung transplantation
is a highly specialized clinical endeavor. Since the late 1980 ′s, there have only been slightly more than 2200 implants reported to the International Society for Heart and Lung transplantation registry. This review will discuss the historical aspects of pediatric lung transplantation. It will familiarize the reader with the current indications for transplant and the referral and listing process. The current state of lung assist devices as a bridge to pediatric lung transplantation is discussed in addition to the technical aspects of the transplant procedure. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Roosevelt Bryant, David Morales, Marc Schecter Source Type: research
Pediatric kidney transplantation
This article reviews the many etiologies of renal failure in the pediatric population focusing on those most commonly leading to the need for kidney transplantation. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Jonathan P. Roach, Margret E. Bock, Jens Goebel Source Type: research
Pediatric intestinal transplantation
The field of intestinal transplantation has experienced dramatic growth since the first reported cases three decades ago. Improvements in operative technique, donor assessment and immunosuppressive protocols have afforded children who suffer from life-threatening complications of intestinal failure a chance at long-term survival. As experience has grown, newer diseases, with more systemic manifestations have arisen as potential indications for transplant. After discussing the historical developments of intestinal transplant as a backdrop, this review focuses on the specific pre-operative indications for transplant as well ...
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Kyle A. Soltys, Geoff Bond, Rakesh Sindhi, Sara K. Rassmussen, Armando Ganoza, Ajai Khanna, George Mazariegos Source Type: research
Immunosuppression in the pediatric transplant recipient
The field of pediatric solid organ transplantation has significantly evolved since its beginnings in the early 20th century. As advancements have led to the development of innovative surgical techniques and novel medication regimens, transplantation has now become a routine practice leading to an increase in the rates of organ recipients worldwide.The care of pediatric solid organ transplant recipients differs from adults in several areas not only due to technically challenging surgeries, but mostly due to the complexity of their immunosuppression management. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Niviann M. Blondet, Patrick J. Healey, Evelyn Hsu Source Type: research
Adherence and the pediatric transplant patient
Adherence is proving to be the Achilles heel of pediatric transplantation. Through a careful literature review on adherence in pediatric solid organ transplantation from 2007 –2017, this chapter reports on the incidence, measuring tools, and consequences of poor adherence. We detail adherence determinants and interventions proposed to foster it.While adherence is a major problem in the adolescent age, it clearly is not limited to this age group. Importantly, it is not one to start tackling at that time or when it becomes apparent. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - July 25, 2017 Category: Pediatrics Authors: Nada A Yazigi Source Type: research
Contents
(Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - June 1, 2017 Category: Pediatrics Source Type: research
Forthcoming topics
(Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - June 1, 2017 Category: Pediatrics Source Type: research
Congenital diaphragmatic hernia: The role of multi-institutional collaboration and patient registries in supporting best practice
Amongst congenital malformations, congenital diaphragmatic hernia (CDH) is distinguished by its relatively low occurrence rate, need for resource intensive, integrated multidisciplinary care, and widespread variation in practice and outcome. Although randomized controlled trials (RCTs) are considered the gold standard for generating evidence, they are poorly suited to the study of a condition like CDH due to challenges in illness severity adjustment, unpredictability in clinical course and the impact limitations of studying a single intervention at a time. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - April 29, 2017 Category: Pediatrics Authors: Pamela A. Lally, Erik D. Skarsgard Source Type: research
Preface
Congenital Diaphragmatic Hernia (CDH) occurs in approximately 1 in approximately every 2500 live births. While uncommon, the high mortality rate and need/use of high intensity care makes the diagnosis one of the most deadly and expensive entities to treat in modern medicine. Along with the high mortality rate, there is growing recognition of significant morbidity in the survivors requiring careful long term follow up. In the ensuing decade since the last edition of Seminars in Pediatric Surgery was published on CDH, much has been learned about the disease. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - April 28, 2017 Category: Pediatrics Authors: Kevin P. Lally Source Type: research
Ventilation modalities in infants with congenital diaphragmatic hernia
Neonates with congenital diaphragmatic hernia are among the more complex patients to support with mechanical ventilation. They have particular features that add to the difficulties already present in the neonatal patient. A ventilation strategy tailored to the patient ′s underlying physiology rather than mode of ventilation is the most important issue for clinicians treating these delicate patients. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - April 25, 2017 Category: Pediatrics Authors: Francesco Morini, Irma Capolupo, Willem van Weteringen, Irwin Reiss Source Type: research
Cardiac dysfunction in congenital diaphragmatic hernia: Pathophysiology, clinical assessment, and management
Cardiac dysfunction is an important consequence of pulmonary hypertension in congenital diaphragmatic hernia and a determinant of disease severity. Increased afterload leads to right ventricular dilatation and diastolic dysfunction. Septal displacement and dysfunction impair left ventricular function, which may also be compromised by fetal hypoplasia. Biventricular failure contributes to systemic hypotension and hypoperfusion. Early and regular echocardiographic assessment of cardiac function and pulmonary artery pressure can guide therapeutic decision-making, including choice and timing of pulmonary vasodilators, cardiotr...
Source: Seminars in Pediatric Surgery - April 24, 2017 Category: Pediatrics Authors: Neil Patel, Florian Kipfmueller Source Type: research
Fetal imaging and therapy for CDH —Current status
We present the antenatal imaging approaches that can help identify fetuses that might benefit from antenatal therapy, and review the evolution of fetal surgery for CDH to date. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - April 24, 2017 Category: Pediatrics Authors: Titilayo Oluyomi-Obi, Tim Van Mieghem, Greg Ryan Source Type: research
Long-term follow-up of congenital diaphragmatic hernia
Increased survival of patients with congenital diaphragmatic hernia has created a unique cohort of children, adolescent, and adult survivors with complex medical and surgical needs. Disease-specific morbidities offer the opportunity for multiple disciplines to unite together to provide long-term comprehensive follow-up, as well as an opportunity for research regarding late outcomes. These children can exhibit impaired pulmonary function, altered neurodevelopmental outcomes, nutritional insufficiency, musculoskeletal changes, and specialized surgical needs that benefit from regular monitoring and intervention, particularly ...
Source: Seminars in Pediatric Surgery - April 24, 2017 Category: Pediatrics Authors: Laura E. Hollinger, Matthew T. Harting, Kevin P. Lally Source Type: research
Cardiac dysfunction in congenital diaphragmatic hernia: Pathophysiology, clinical assessment and management
Cardiac dysfunction is an important consequence of pulmonary hypertension in congenital diaphragmatic hernia and a determinant of disease severity. Increased afterload leads to right ventricular dilatation and diastolic dysfunction. Septal displacement and dysfunction impair left ventricular function, which may also be compromised by fetal hypoplasia. Biventricular failure contributes to systemic hypotension and hypo-perfusion. Early and regular echocardiographic assessment of cardiac function and pulmonary artery pressure can guide therapeutic decision-making, including choice and timing of pulmonary vasodilators, cardiot...
Source: Seminars in Pediatric Surgery - April 24, 2017 Category: Pediatrics Authors: Neil Patel, Florian Kipfmueller Source Type: research
