Congenital diaphragmatic hernia: The role of multi-institutional collaboration and patient registries in supporting best practice

Amongst congenital malformations, congenital diaphragmatic hernia (CDH) is distinguished by its relatively low occurrence rate, need for resource intensive, integrated multidisciplinary care, and widespread variation in practice and outcome. Although randomized controlled trials (RCTs) are considered the gold standard for generating evidence, they are poorly suited to the study of a condition like CDH due to challenges in illness severity adjustment, unpredictability in clinical course and the impact limitations of studying a single intervention at a time.
Source: Seminars in Pediatric Surgery - Category: Pediatrics Authors: Source Type: research