Editorial Board
(Source: Seminars in Oncology)
Source: Seminars in Oncology - April 1, 2017 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Seminars in Oncology)
Source: Seminars in Oncology - April 1, 2017 Category: Cancer & Oncology Source Type: research
Pseudo-progressing to an unmet need
In this issue we bring you a collection of articles that reflect what you will see going forward in Seminars in Oncology. Thorough, thoughtful reviews, rich in data summarized in a format that is reader-friendly, often accompanied by the wisdom of experts who bring perspectives seasoned by years of experience and reflection. Four such reviews discussing screening for the most common solid tumors, highlight that screening remains a “work in progress” and underscore the challenges we still face decades after screening was first conceived. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 23, 2017 Category: Cancer & Oncology Authors: Tito Fojo Tags: Editorial Source Type: research
Commentary: Prostate cancer screening —A long run for a short slide
Enthusiasm for cancer screening is rooted in the early 20th century Halstedian paradigm that cancer is a localized, curable disease, which left untreated, will eventually spread to distant sites and become lethal [1 –3]. However, the natural history of malignancy has proved to be far more variable, ranging from cancers that have already metastasized by the time of diagnosis to those that remain indolent throughout their natural history, or even regress. Digital rectal examination [4] and transrectal ultrasoun d (TRUS) were the first prostate cancer early detection tools. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 18, 2017 Category: Cancer & Oncology Authors: Howard L. Parnes Source Type: research
Screening for Lung Cancer
This review will comprise a general overview of the epidemiology of lung cancer, as well as lung cancer risk factors, screening modalities, current guideline recommendations for screening, and our approach to lung cancer screening. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 13, 2017 Category: Cancer & Oncology Authors: Heather F. Sateia, Youngjee Choi, Rosalyn W. Stewart, Kimberly S. Peairs Source Type: research
Screening for breast cancer
This review will give a general overview of the impact of breast cancer, as well as breast cancer risk factors, identification of high-risk groups, screening modalities, and guidelines for screening average-risk and high-risk individuals, including a case discussion of the primary care provider ’s approach to screening. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 12, 2017 Category: Cancer & Oncology Authors: Kimberly S. Peairs, Youngjee Choi, Rosalyn W. Stewart, Heather F. Sateia Tags: Choi: Recommendations for physicians Source Type: research
Commentary: Choosing how to screen for colorectal cancer
The article by Choi et al in this issue of Seminars in Oncology [1] is an excellent review of the different modalities available for colorectal cancer screening. While one often hears that the best screening test is the one that the patient will accept (and there is truth to this axiom), for the most part one can infer from the paper by Choi et al that barium enemas and computed tomography (CT) colonography are, respectively, no longer appropriate and not yet appropriate for this purpose. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Alfred I. Neugut, Benjamin Lebwohl Source Type: research
Screening for Prostate Cancer
This review comprises a general overview of the impact and risk factors for prostate cancer. Evidenced-based professional society prostate cancer screening guideline recommendations are reviewed, and our approach to a case is presented. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Rosalyn W. Stewart, Sergio Lizama, Kimberly Peairs, Heather F. Sateia, Youngjee Choi Source Type: research
Screening for colorectal cancer
This review will comprise a general overview of the impact of colorectal cancer (CRC), as well as CRC risk factors, screening modalities, guideline recommendations for screening in average-risk and high-risk individuals, and our approach to CRC screening. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Youngjee Choi, Heather F. Sateia, Kimberly S. Peairs, Rosalyn W. Stewart Source Type: research
Characterization of outcomes in patients with metastatic non-small cell lung cancer treated with programmed cell death protein 1 inhibitors past RECIST v1.1-defined disease progression in clinical trials
Based on anecdotal cases of clinically important decreases in tumor size following initial evidence of disease progression when treating patients with anti-PD-1 therapies, investigators have conducted clinical trials in patients with metastatic non-small lung cancer (mNSCLC) receiving anti-PD-1 therapy allowing for treatment past RECIST-defined disease progression (TPP). However, it remains unclear what the true benefit of TPP is. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Dickran Kazandjian, Patricia Keegan, Daniel L Suzman, Richard Pazdur, Gideon M Blumenthal Source Type: research
A Multicenter Phase II Study of Personalized FOLFIRI-Cetuximab for Safe Dose Intensification
We conducted a multicenter proof of concept phase II trial in patients with advanced colorectal cancer receiving FOLFIRI-Cetuximab regimens to explore individual drug tailoring using pharmacogenetics and PK-monitoring. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: O. Capitain, J.P. Metges, M. Boisdron-Celle, A. Adenis, J.L. Raoul, T. Lecomte, Y.H. Lam, R. Faroux, C. Masliah, A.L. Poirier, V. Berger, A. Morel, E. Gamelin Source Type: research
What constitutes an “unmet medical need” in oncology? An empirical evaluation of author usage in the biomedical literature
The phrase “unmet medical need” has important regulatory implications, but there is no empirical analysis of its real world usage. We sought to determine the annual US incidence, 5-year survival, and number of National Comprehensive Cancer Network (NCCN) recommended regimens for indications described in th e literature as an “unmet medical need.” (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Eric Lu, Joseph Shatzel, Florence Shin, Vinay Prasad Source Type: research
Choosing How to Screen for Colorectal Cancer
The article by Choi, et al. in the Seminars [1] is an excellent review of the different modalities available for colorectal screening. While one often hears that the best screening test is the one that the patient will accept (and there is truth to this axiom), for the most part one can infer from the paper by Choi, et al. that barium enemas and CT colonography are, respectively, no longer appropriate and not yet appropriate for this purpose. (Source: Seminars in Oncology)
Source: Seminars in Oncology - February 9, 2017 Category: Cancer & Oncology Authors: Alfred I. Neugut, Benjamin Lebwohl Source Type: research
Commentary on “Screening for lung cancer” by Sateia et al
In their review article, Satiea et al discuss the burden of lung cancer and the potential benefits and harms of low-dose computed tomographic (LDCT) lung cancer screening [1]. As lung cancer is the most common cause of cancer mortality in the developing world, the promise of a mortality reduction on the order of 15% –20% among those undergoing screening, as observed in the National Lung Screening Trial (NLST), is alluring. However, for the potential of LDCT screening to be optimized, the harms must be minimized and screening must be effectively targeted to persons both at high risk and also able to benefit fr om curative...
Source: Seminars in Oncology - February 7, 2017 Category: Cancer & Oncology Authors: Paul F. Pinsky Source Type: research
Commentary on “Screening for breast cancer” by Peairs et al
This issue of Seminars in Oncology includes a review article by Peairs et al entitled “Screening for breast cancer”. As expected, the primary focus of the article is breast cancer screening; the authors report on the harms and benefits of screening, use of different modalities and screening intervals, professional guidelines, and screening in high-risk groups. The review article places this in the context of providing personalized recommendations for a 48-year-old African American woman. The authors provide a detailed discussion on breast cancer risk factors relevant to the final part of the article, which covers the a...
Source: Seminars in Oncology - February 7, 2017 Category: Cancer & Oncology Authors: Pamela M. Marcus, Danielle D. Durham Source Type: research
