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Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke
Conclusion: Iron and heme are associated with a pro-inflammatory response in the central nervous system following hemorrhagic stroke, and protections against hemoglobin and heme are lacking within the human brain. Patient inflammatory profiles were associated with a poorer prognosis, and local anti-inflammatory responses appeared to have a protective role. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - May 7, 2018 Category: Intensive Care Source Type: research

Acute kidney injury and intra-abdominal hypertension in burn patients in intensive care
Conclusion: Intra-abdominal hypertension occurred in most patients, predominantly in grades I and II. The identified risk factors for the occurrence of acute kidney injury were intra-abdominal hypertension and use of glycopeptides, vasopressors and mechanical ventilation. Acute kidney injury was associated with increased 30-day mortality. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - May 7, 2018 Category: Intensive Care Source Type: research

What every intensivist should know about the management of peritonitis in the intensive care unit
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - May 7, 2018 Category: Intensive Care Source Type: research

First Brazilian datathon in critical care
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - May 7, 2018 Category: Intensive Care Source Type: research

From the International Pediatric Sepsis Conference 2005 to the Sepsis-3 Consensus
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - May 7, 2018 Category: Intensive Care Source Type: research

Erratum
RESUMO Pacientes cr íticos internados em unidade de terapia intensiva devem ser mobilizados com base em critérios de segurança. O objetivo desta revisão foi verificar os critérios de segurança mais utilizados para iniciar a mobilização precoce em pacientes sob ventilação mecânica internados em unidade de ter apia intensiva. Os artigos foram pesquisados nas bases de dados PubMed, PEDro, LILACS, Cochrane e CINAHL, tendo sido incluídos ensaios clínicos randomizados e controlados, ensaios clínicos quase randomizados, coortes, estudos comparativos com ou sem controles simultâneos, séries de casos com de z ou mai...
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Sepsis definitions
RESUMO Pacientes cr íticos internados em unidade de terapia intensiva devem ser mobilizados com base em critérios de segurança. O objetivo desta revisão foi verificar os critérios de segurança mais utilizados para iniciar a mobilização precoce em pacientes sob ventilação mecânica internados em unidade de ter apia intensiva. Os artigos foram pesquisados nas bases de dados PubMed, PEDro, LILACS, Cochrane e CINAHL, tendo sido incluídos ensaios clínicos randomizados e controlados, ensaios clínicos quase randomizados, coortes, estudos comparativos com ou sem controles simultâneos, séries de casos com de z ou mai...
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Safety criteria to start early mobilization in intensive care units. Systematic review
RESUMO Pacientes cr íticos internados em unidade de terapia intensiva devem ser mobilizados com base em critérios de segurança. O objetivo desta revisão foi verificar os critérios de segurança mais utilizados para iniciar a mobilização precoce em pacientes sob ventilação mecânica internados em unidade de ter apia intensiva. Os artigos foram pesquisados nas bases de dados PubMed, PEDro, LILACS, Cochrane e CINAHL, tendo sido incluídos ensaios clínicos randomizados e controlados, ensaios clínicos quase randomizados, coortes, estudos comparativos com ou sem controles simultâneos, séries de casos com de z ou mai...
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Toxic epidermal necrolysis: a paradigm of critical illness
RESUMEN La necrolisis epid érmica tóxica es una reacción cutánea adversa de tipo inmunológico secundaria en la mayor parte de los casos a la administración de un fármaco. La necrolisis epidérmica tóxica, el síndrome de Steven Johnson y el eritema exudativo multiforme forman parte del mismo espectro de enfermedad. La mortalidad de la necrolisis epidérmica tóxica es alrededor del 30%. La fisiopatología de la necrolisis epidérmica tóxica es semejante en muchos aspectos a la de las quemaduras dérmicas superficiales. La afectación mucosa del epitelio ocular y genital se asocia con secuelas graves si no se tr a...
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients
RESUMO A dobutamina é o inotrópico mais comumente utilizado em pacientes com choque séptico, com o objetivo de aumentar o débito cardíaco e corrigir a hipoperfusão. Embora alguns ensaios clínicos tenham demonstrado que a dobutamina pode melhorar a hemodinâmica sistêmica e regional, outras pesquisas identificar am que seus efeitos são heterogêneos e imprevisíveis. Nesta revisão, analisamos as propriedades farmacodinâmicas da dobutamina e seus efeitos fisiológicos. Nosso objetivo foi demonstrar que os efeitos da dobutamina podem diferir entre voluntários saudáveis, estudos experimentais e insuficiê ncia car...
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Autonomic nervous system monitoring in intensive care as a prognostic tool. Systematic review
Conclusion: In patients admitted to intensive care units, regardless of the pathology, heart rate variability varies inversely with clinical severity and prognosis. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Bedside ultrasound is a practical measurement tool for assessing muscle mass
Conclusion: The data analyzed showed a good correlation between the measurements made by the coach and trainees, indicating that ultrasound of the quadriceps muscle is a viable and easily applicable tool. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Weakness acquired in the intensive care unit. Incidence, risk factors and their association with inspiratory weakness. Observational cohort study
Conclusion: The intensive care unit acquired weakness is a condition with a high incidence in our environment. The development of intensive care unit-acquired weakness was associated with age, delirium, hyperglycemia, and mechanical ventilation> 5 days. The maximum inspiratory pressure value of ≥ 36cmH2O was associated with a high diagnostic value to exclude the presence of intensive care unit -acquired weakness. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Functional evaluation of pediatric patients after discharge from the intensive care unit using the Functional Status Scale
Conclusion: Evaluation of the functional status using the Functional Status Scale indicated moderate impairment in patients after discharge from the pediatric intensive care unit, mainly in the "motor function" and "feeding" domains; patients who were readmitted to the pediatric intensive care unit demonstrated worse overall functional, motor function, feeding and respiratory scores. Individuals with greater functional impairment had longer times of invasive mechanical ventilation and hospitalization in the pediatric intensive care unit. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research

Assessment of PIM-2 performance among surgical patients with heart disease and correlation of results with RACHS-1
Conclusion: RACHS presented good calibration power, and RACHS-1 and PIM-2 demonstrated good performance with regard to their discriminating capacities between survivors and non-survivors. Moreover, a positive correlation was found between the results of the two risk scores. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - January 15, 2018 Category: Intensive Care Source Type: research