Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women
Major depressive episodes occur twice as frequent in women compared to men (Kessler et al., 2005), and women also tend to exhibit greater symptom severity and higher rates of co-morbid disorders (Marcus et al., 2008). A recent nationwide Danish cohort study of trends in depression replicated the women to men risk ratio of 2 to 1, and further replicated an even higher risk ratio for adolescent girls from expected time of puberty onset (age 12-19) with a girls to boys risk ratio of 2.7 to 1 (Skovlund et al., 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 26, 2018 Category: Psychiatry Authors: DS Stenb æk, E Budtz-Jørgensen, Pinborg A, PS Jensen, VG Frokjaer Source Type: research
Editorial Board
(Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Source Type: research
Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy
Laparoscopic sleeve gastrectomy (LSG) is a surgical procedure that leads to the removal of the gastric fundus. It is currently one of the most effective treatments for morbid obesity (Diamantis et al., 2014). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Authors: Guanya Li, Gang Ji, Yang Hu, Li Liu, Qingchao Jin, Wenchao Zhang, Lei Liu, Yuanyuan Wang, Jizheng Zhao, Karen M. von Deneen, Antao Chen, Guangbin Cui, Yu Han, Huaning Wang, Qingchuan Zhao, Kaichun Wu, Corinde E. Wiers, Dardo Tomasi, Lorenzo Leggio, Nora D Source Type: research
Associations of Cord Blood Leptin and Adiponectin with Children ’s Cognitive Abilities
Leptin and adiponectin are peptide hormones secreted by adipose tissue and the placenta that play a role in metabolism and possibly neurodevelopment (Masuzaki et al., 1997; Chen et al., 2006; Arnoldussen et al., 2014). Leptin receptors are distributed throughout the brain, and leptin acts in multiple brain regions that are important for cognition (Funahashi et al., 2003; Farr et al., 2006; Oomura et al., 2006; Morrison, 2009). In mice, short-term leptin infusions improved memory and learning (Farr et al., 2006; Oomura et al., 2006). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Authors: Nan Li, Tye E Arbuckle, Gina Muckle, Bruce P Lanphear, Michel Boivin, Aimin Chen, Linda Dodds, William D Fraser, Emmanuel Ouellet, Jean R S éguin, Maria P Velez, Kimberly Yolton, Joseph M Braun Source Type: research
Stress and immunosenescence: The role of telomerase
Chronic stress is a major contributor to the development and progression of a range of physical and mental disorders such as cardiovascular disease, type 2 diabetes, metabolic syndrome, autoimmune disease and depression (Cohen et al., 2007). Several lines of evidence converge to suggest that these pathophysiological effects of stress on health and disease risk are mediated in large part by rate of accelerated aging of the immune system (immunosenescence). This process is characterized by the inability to mount an appropriate and effective immune response to challenge, and it is associated with a low-grade chronic pro-infla...
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: Karin de Punder, Christine Heim, Pathik D. Wadhwa, Sonja Entringer Source Type: research
Major depression and atrial natriuretic peptide: the role of adverse childhood experiences
Neuroendocrine peptides have been increasingly acknowledged in psychiatric research due to their actions in the central nervous system (CNS) (Bandelow et al., 2017). Atrial natriuretic peptide (ANP) is a 28 amino acid peptide, which is synthesised in cardiomyocytes and acts in the context of blood pressure regulation. Reduced basal ANP levels have been associated with cardiovascular disease, overweight, hypertension, and insulin resistance (Wis én et al., 2011). In the CNS, ANP is expressed in the hypothalamus, brainstem, cerebellum, and cerebral cortex (Meyer and Herrmann-Lingen, 2018). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: M. Kaczmarczyk, C. Otte, K. Wiedemann, L.K. Kuehl, K. Schultebraucks, C. Spitzer, K. Wingenfeld Tags: Short Communication Source Type: research
Higher trait reappraisal predicts stronger HPA axis habituation to repeated stress
Psychosocial stress is a common occurrence in daily life, consisting of various challenges, threats, loss, and harm (Lazarus, 1966). Undergoing stress can be advantageous when it leads to adaptation and growth. Conversely, the inability to adapt to repeated stress is linked with declines in cognitive functioning, systemic inflammation, premature aging, immune system dysfunction, and higher likelihood of suffering from metabolic disorders such as diabetes and cardiovascular disease (Cohen et al., 2012; Graham et al., 2006; Glaser& Kiecolt-Glaser, 2005; Tamashiro et al., 2011). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: Lydia G. Roos, Johanna Janson, Sarah C. Sturmbauer, Jeanette M. Bennett, Nicolas Rohleder Source Type: research
PTSD psychotherapy improves blood pressure but leaves HPA axis feedback sensitivity stable and unaffected: first evidence from a pre-post treatment study
Although key to development of tailored drugs for augmentation treatment of psychotherapy for posttraumatic stress disorder (PTSD), the biological correlates of PTSD remission are still unknown, probably because pre-post treatment studies searching for them are rare. Not even the feedback sensitivity of the otherwise well-studied hypothalamic-pituitary-adrenal (HPA) axis nor arterial blood pressure (BP), which was previously reported to be elevated in PTSD patients, have so far been analyzed during PTSD treatment. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 21, 2018 Category: Psychiatry Authors: Christine F. Schubert, Monika Schreckenbach, Thomas Kirmeier, Dominique J. Gall-Kleebach, Bastian Wollweber, Dominik R. Buell, Uhr M, Rita Rosner, Ulrike Schmidt Source Type: research
Over-expression of TGF- β1 gene in medication free Schizophrenia
Immunological pathways play a crucial role in developing and precipitating neuropsychiatric disorders. Although the exact pathogenesis of schizophrenia is unknown, the possible role of genetic and biomarker involvement of the immune system is gaining attention. Here we quantified the mRNA expression of cytokines as a key role player of the immune system from the peripheral blood mononuclear cells of patients with schizophrenia and healthy controls to identify the differentially expressed genes. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 20, 2018 Category: Psychiatry Authors: Mahsa M. Amoli, Fatemeh Khatami, Seyed Masoud Arzaghi, Samaneh Enayati, Ali-Akbar Nejatisafa Source Type: research
Cortisol, dehydroepiandrosterone sulfate, fatty acids and their relation in recurrent depression
The overwhelming burden of major depressive disorder (MDD) is mainly due to its recurrent nature (Charlson et al., 2011). Suggested mechanisms underlying the recurrent course of MDD include alterations in endocrinology and metabolism. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 19, 2018 Category: Psychiatry Authors: D.M. ter Horst, A.H. Schene, C.A. Figueroa, J. Assies, A. Lok, C.L.H. Bockting, H.G. Ruh é, R.J.T. Mocking Source Type: research
BDNF Val66Met Polymorphism and Posttraumatic Stress Symptoms in U.S. Military Veterans: Protective Effect of Physical Exercise
Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by intrusive symptoms, avoidance of trauma reminders, negative thoughts and mood, and alterations in arousal and reactivity that affects approximately 8% of U.S. military veterans in their lifetimes (Wisco et al., 2016). There is increasing interest in identifying genetic markers for PTSD, and understanding how these markers may be moderated by environmental and psychosocial risk and protective factors (e.g., Mota et al., 2018). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 17, 2018 Category: Psychiatry Authors: Barbara L. Pitts, Julia M. Whealin, Ilan Harpaz-Rotem, Ronald S. Duman, John H. Krystal, Steven M. Southwick, Robert H. Pietrzak Tags: Short Communication Source Type: research
Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
In recent years, the role of intestinal microbiota, as a component of the microbiota-gut-brain axis, has become an important player in neuroscience and psychiatric research. Animal and human studies point out the role of those bacteria in maintaining the psycho-neuro-immunological balance through various actions, such as the modulation of the immune and the neuroendocrine systems e.g. hypothalamic-pituitary adrenal axis (HPA), changes of the TRP metabolism in the serotonin (5-HT) and the kynurenine axes, regulation of the neurogenesis and improvement of intestinal permeability. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 16, 2018 Category: Psychiatry Authors: Leszek Rudzki, Lucyna Ostrowska, Dariusz Pawlak, Aleksandra Ma łus, Krystyna Pawlak, Napoleon Waszkiewicz, Agata Szulc Source Type: research
Social stability influences the association between adrenal responsiveness and hair cortisol concentrations in rhesus macaques
The concentration of cortisol in hair is increasingly being used in a wide variety of species as a biomarker of chronic stress. Taxa examined so far include domesticated pets and livestock (Accorsi et al., 2008; Comin et al., 2011; Keckeis et al., 2012), mammalian wildlife (Ashley et al., 2011; Bechsh øft et al., 2011; Koren et al., 2008; Martin and Réale, 2008), non-human primates (Davenport et al., 2006; Dettmer et al., 2014; Hamel et al., 2011; Laudenslager et al., 2011), and humans (e.g. D'Anna-Hernandez et al., 2011; Dettenborn et al., 2010; Sauvé et al., 2007; Van Uum et al., 2008). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 12, 2018 Category: Psychiatry Authors: J. Vandeleest, J.P. Capitanio, A. Hamel, J. Meyer, M. Novak, S.P. Mendoza, B. McCowan Source Type: research
The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers
The mother-infant dyad is meant to be an open, non-linear dynamic system in which mothers and infants reciprocally regulate their states in order to adjust to challenging and stressful conditions (Provenzi et al., 2015a,b; Tronick& Beeghly, 2011). The emergence of patterns of behavioral and biological rhythms co-regulation is key to this dyadic self-regulating system (Feldman, 2006; Welch, 2016). At the behavioral level, mother-infant coordination has been widely investigated (Provenzi et al., 2018) and conceptualized as a coupling of behavioral and affective states in a given moment (e.g., dyadic matching; Weinberg et al....
Source: Psychoneuroendocrinology - October 12, 2018 Category: Psychiatry Authors: Livio Provenzi, Lorenzo Giusti, Monica Fumagalli, Susanna Frigerio, Francesco Morandi, Renato Borgatti, Fabio Mosca, Rosario Montirosso Source Type: research
Grief, Depressive Symptoms, and Inflammation in the Spousally Bereaved
The loss of a spouse is an extremely stressful life event that puts people at risk for mental and physical health problems (Stahl et al., 2016). Bereavement is linked with an increased risk of cardiovascular disease (CVD), and premature mortality (Moon et al., 2013). Even after adjusting for established risk factors, the death of a spouse is associated with an increased rate of mortality from cardiovascular events (Hart et al., 2007). The first 3 months after the loss of a spouse puts people at the greatest risk for cardiovascular events (Shor et al., 2012). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 11, 2018 Category: Psychiatry Authors: Christopher Fagundes, Ryan L. Brown, Michelle A. Chen, Kyle W. Murdock, Levi Saucedo, Angie LeRoy, E. Lydia Wu, Luz M. Garcini, Anoushka D. Shahane, Faiza Baameur, Cobi Heijnen Source Type: research
