Macrophage migration inhibitory factor (MIF) gene associated with adolescents ’ cortisol reactivity and anxiety
Adolescence is marked by drastic shifts in neuroendocrine activity and stress physiology which may confer risk for affective disorders (Gunnar et al., 2009; Romeo, 2013; Stroud et al., 2009). The Hypothalamus Pituitary Adrenal (HPA) axis, part of the neuroendocrine system, regulates stress response during acute or chronic stress. Identifying factors that contribute to its dysregulation during adolescence may have important clinical implications. Macrophage Migration Inhibitory Factor (MIF) is a well-established inflammatory marker and regulator of the HPA axis (Dunn, 2000; Turnbull and Rivier, 1995). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 26, 2018 Category: Psychiatry Authors: Rebecca Lipschutz, Johanna Bick, Victoria Nguyen, Maria Lee, Lin Leng, Elena Grigorenko, Richard Bucala, Linda C. Mayes, Michael J. Crowley Source Type: research
Effects of androstadienone on dominance perception in males with low and high social anxiety
Social chemosignaling is an important means of communication for all mammals (Dulac and Torello, 2003; Brennan and Zufall, 2006). Such social chemosignaling is especially prominent in behaviors related to social hierarchy, territory and reproduction (Dulac and Torello, 2003; Wyatt, 2003; Brennan and Zufall, 2006). Social status, namely social dominance and social submissiveness, is known to be conveyed through chemosignals in rodents (Jones and Nowell, 1973; Novotny et al., 1990). Moreover, over the last decade increasing evidence suggests that humans also can communicate both trait-dominance (Havlicek et al., 2005; Soroko...
Source: Psychoneuroendocrinology - May 25, 2018 Category: Psychiatry Authors: Banner Amir, S.G. Simone Shamay-Tsoory Source Type: research
Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies
Oxytocin is a neuropeptide that has a critical role in human social behaviours; including social perception, social cognition, and social memory (Macdonald and Macdonald, 2010). For this reason, oxytocin research has garnered serious interest within the scientific community, popular press and general public (Bartz et al, 2011). Since the first study was published in 2005 (Kirsch et al, 2005), there has been a fourfold increase in neuroimaging studies on the neurobiological effects of oxytocin when administered intranasally (Fig. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 24, 2018 Category: Psychiatry Authors: Sally A. Grace, Susan L. Rossell, Markus Heinrichs, Catarina Kordsachia, Izelle Labuschagne Source Type: research
Attachment Security Buffers the HPA Axis of Toddlers Growing up in Poverty or Near Poverty: Assessment During Pediatric Well-Child Exams with Inoculations
In the United States, between a fifth and a quarter of children are growing up in poverty and approximately another twenty percent live in households with incomes in the near poor range (Yoshikawa et al., 2012). Growing up poor in disadvantaged neighborhoods increases an individual ’s risk of a range of adverse physical and mental health outcomes (Aber et al., 1997; Diez Roux& Mair, 2010; Yoshikawa et al., 2012), including early death (Meijer et al., 2012). Recent work has also noted a range of socioeconomic variables may have significant impacts on brain development (see review, Farah, 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 22, 2018 Category: Psychiatry Authors: Anna B. Johnson, Shanna B. Mliner, Carrie E. Depasquale, Michael Troy, Megan R. Gunnar Source Type: research
Corrigendum to “The role of genetic variation in the glucocorticoid receptor (NR3C1) and mineralocorticoid receptor (NR3C2) in the association between cortisol response and cognition under acute stress” [Psychoneuroendocrinology 87 (2018) 173–180]
The authors regret to inform the scientific community about changes to a paper recently published in Psychoneuroendocrinology. In this paper we reported that two haplotypes of the NR3C1 and NR3C2 genes were significantly associated with a stress-induced response of the HPA axis. Furthermore, there was a NR3C2 haplotype x cortisol response interaction on attentional performance in our sample. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 22, 2018 Category: Psychiatry Authors: Thomas Plieger, Andrea Felten, Hanna Splittgerber, Éilish Duke, & Martin Reuter Tags: Corrigendum Source Type: research
Role of oxytocin in the ventral tegmental area in social reinforcement
Social reward is a critical element in the development, expression, and maintenance of social behaviors and relationships (Suomi et al., 1971, Krach et al., 2010, Trezza et al., 2011). Despite the importance of social reward in adaptive and maladaptive behaviors, much remains to be learned about the reinforcing properties of social interaction and the neurobiological mechanisms underlying its rewarding properties. Various types of social interactions can serve as behavioral reinforcers (Everitt et al., 1987, Lee et al., 2000, Matthews et al., 2005, Trezza et al., 2011). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 21, 2018 Category: Psychiatry Authors: Johnathan M. Borland, Kymberly N. Grantham, Lauren M. Aiani, Kyle J. Frantz, H. Elliott Albers Source Type: research
Endoplasmic Reticulum Stress in Bipolar Disorder? – BiP and CHOP gene expression- and XBP1 splicing analysis in peripheral blood
Bipolar Disorder (BD) is characterized by mood swings between euphoria and depressed mood (Rothenh äusler HB 2007). The exact mechanisms of these mood swings are still cryptic and must be further elucidated. There is growing evidence from previous in-vitro studies that the Endoplasmic Reticulum (ER), the protein folding factory of the cell, plays a major role in BD (Pfaffenseller et al., 2014, H ayashi et al., 2009, So et al. 2007). The membranous ER network is essential, because it shelters ribosomal protein synthesis, stores calcium for signal transduction and is responsible for the correct folding of proteins. (Source:...
Source: Psychoneuroendocrinology - May 21, 2018 Category: Psychiatry Authors: Susanne A. Bengesser, Eva Z. Reininghaus, Nina Dalkner, Armin Birner, Helena Hohenberger, Robert Queissner, Frederike Fellendorf, Martina Platzer, Rene Pilz, Carlo Hamm, Alexandra Rieger, Hans-Peter Kapfhammer, Harald Mangge, Bernd Reininghaus, Nathalie M Source Type: research
Can prebiotics assist in the Management of Cognition and Weight Gain in Schizophrenia?
Schizophrenia is among the top half of the 25 leading causes of disabilities worldwide with a 10 –20 year decrease in life expectancy. Ineffective pharmacotherapy in the management of cognitive deficits and weight gain are known to be significant contributors; therefore interventions that may mitigate one, or both, of these parameters would be highly beneficial. Manipulation of the gut micr obiome using dietary supplements such as prebiotics may be one such intervention. Preclinical studies have shown that a 2-4 week dietary supplementation with a prebiotic has beneficial effects on learning and memory, and prevents pr...
Source: Psychoneuroendocrinology - May 19, 2018 Category: Psychiatry Authors: Amy Chia-Ching Kao, Philip W.J. Burnet, Belinda Lennox Source Type: research
Antidepressant Treatment Resistance is Associated with Increased Inflammatory Markers in Patients with Major Depressive Disorder
Major Depressive Disorder (MDD) affects approximately 10% of the US adult population and is the leading cause of disability worldwide (Friedrich, 2017; Global Burden of Disease Study, 2015). Despite recent advances in understanding the pathophysiology of MDD, approximately 30% of patients with MDD remain treatment refractory following multiple treatment trials with currently available antidepressant medications (Rush et al., 2006). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 19, 2018 Category: Psychiatry Authors: Ebrahim Haroon, Alexander W. Daguanno, Bobbi J. Woolwine, David R. Goldsmith, Wendy M. Baer, Evanthia C. Wommack, Jennifer C. Felger, Andrew H. Miller Source Type: research
Maternal distress and hair cortisol in pregnancy among women with elevated adverse childhood experiences
Stress throughout the life-course is associated with a wide-range of adverse health outcomes. Accumulating evidence from animal and several human studies suggests that maternal distress and adversity experienced during pregnancy, including depression, anxiety, general and pregnancy-specific stress can increase the risk for impaired infant development.(Talge et al., 2007) Families in poverty, such as those participating in home visiting intervention programs, carry a high burden of adversity including increased early life stressors and family exposure to psychosocial stressors (e.g., violence, residential instability, food ...
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Katherine Bowers, Lili Ding, Samantha Gregory, Kimberly Yolton, Hong Ji, Jerrold Meyer, Robert T. Ammerman, Judith Van Ginkel, Alonzo Folger Tags: Short Communication Source Type: research
Emerging literature in the microbiota-brain axis and Perinatal Mood and Anxiety Disorders
Perinatal Mood and Anxiety Disorders (PMAD), including Antenatal Depression (AND) and Postpartum Depression (PPD), are one of the most common postpartum complications affecting 10-20% of perinatal women (Andersson et al., 2006; Cooper et al., 1988; Dietz et al., 2007; Evans et al., 2001; Gaynes et al., 2005; Josefsson et al., 2001; O ’Keane and Marsh, 2007). In severe cases, these disorders can be crippling (Abramowitz et al., 2010; Bernstein et al., 2008), and in developed nations, suicide is one of the largest contributors to maternal mortality (Palladino et al., 2011; Gentile, 2011; Oates, 2003; Lindahl et al., 2005)....
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Hannah S. Rackers, Stephanie Thomas, Kelsey Williamson, Rachael Posey, Mary C. Kimmel Source Type: research
Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length
According to the Developmental Origins of Health and Disease theory, many human disease processes begin as early as the fetal period, even if symptoms do not emerge until late in life (Gluckman et al., 2008). Various maternal exposures have been identified as robust influencers on fetal development and, ultimately, offspring physical and mental health and neurodevelopment (Entringer et al., 2015; Van den Bergh et al., 2017). Importantly, evidence suggests that these exposures may not uniformly affect male and female offspring (Van den Bergh et al., 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Michelle Bosquet Enlow, Valentina Bollati, Georgios Sideridis, Julie D. Flom, Mirjam Hoxha, Michele Hacker, Rosalind J. Wright Source Type: research
Basal cortisol levels and metabolic syndrome: a systematic review and meta-analysis of observational studies
Metabolic syndrome (MetS) is a clinical condition characterized by a combination of different metabolic factors, including hyperglycemia, hypertension, reduced high-density lipoprotein cholesterol, elevated triglycerides, and abdominal obesity (Alberti et al., 2009). A Joint Interim Statement compiled by different organizations defined MetS as the concomitant presence of three of these five factors (Alberti et al., 2009). The prevalence of MetS is increasing continuously worldwide (Beltran-Sanchez et al., 2013; Mozumdar and Liguori, 2011), and the National Health and Nutrition Examination Survey 2003-2012 estimated that ne...
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Anderson Garcez, Helo ísa Marquardt Leite, Elisabete Weiderpass, Vera Maria Vieira Paniz, Guilherme Watte, Raquel Canuto, Maria Teresa Anselmo Olinto Source Type: research
Main and interaction effects of childhood trauma and the MAOA uVNTR polymorphism on psychopathy
Antisocial behavior includes a range of behavioral aspects such as aggression, disrespect for social norms, and irresponsibility, but also legal aspects related to criminality and delinquency (Morgan and Lilienfeld, 2000). Antisocial behavior, in combination with an unstable lifestyle, represents one important component (i.e., social deviance) of the psychopathy construct described by Hare (2003). However, psychopathy is not only characterized by social deviance, but more strongly by a restricted range and depth of emotions, manipulative skills, and deceitfulness (i.e., psychopathic core personality traits; Herpertz and Sa...
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Pia Hollerbach, Ada Johansson, Daniel Ventus, Patrick Jern, Craig S. Neumann, Lars Westberg, Pekka Santtila, Elmar Habermeyer, Andreas Mokros Source Type: research
Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue
Converging lines of evidence from genetics, post-mortem neuropathology, neuroimaging and peripheral biomarker studies suggest that at least a sub-set of patients with schizophrenia have elevated peripheral and central inflammation (Baumeister et al., 2014; Mondelli et al., 2017). Whether antipsychotic drug treatment has a confounding effect on these data remains controversial (Cotel et al., 2015; Baumeister et al., 2016). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 17, 2018 Category: Psychiatry Authors: Anita Calevro, Marie-Caroline Cotel, Sridhar Natesan, Michel Modo, Anthony C. Vernon, Valeria Mondelli Source Type: research
