Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments
Publication date: Available online 12 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Marcos V. Perini, Rhynelle S. Dmello, Tracy L. Nero, Ashwini L. Chand (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 13, 2020 Category: Drugs & Pharmacology Source Type: research
Exploring the proteasome system: A novel concept of proteasome inhibition and regulation
Publication date: Available online 13 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Xinyuan Wang, Thomas Meul, Silke Meiners (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 13, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans
Publication date: Available online 12 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Tessa de Vries, Carlos M. Villalón, Antoinette MaassenVanDenBrink (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 12, 2020 Category: Drugs & Pharmacology Source Type: research
Replacement of current opioid drugs focusing on MOR-related strategies
Publication date: Available online 9 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, Alain Eschalier (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 10, 2020 Category: Drugs & Pharmacology Source Type: research
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders
Publication date: Available online 9 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Lucio G. Costa, Toby B. Cole, Khoi Dao, Yu-Chi Chang, Jacki Coburn, Jacqueline M. Garrick (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 9, 2020 Category: Drugs & Pharmacology Source Type: research
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention
Publication date: Available online 9 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Andrea Carlo Rossetti, Maria Serena Paladini, Marco Andrea Riva, Raffaella Molteni (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 9, 2020 Category: Drugs & Pharmacology Source Type: research
Review - Pharmacological targets of metabolism in disease: Opportunities from macrophages
Publication date: Available online 6 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Alessandra Castegna, Rosanna Gissi, Alessio Menga, Monica Montopoli, Maria Favia, Antonella Viola, Marcella Canton (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 8, 2020 Category: Drugs & Pharmacology Source Type: research
Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights
Publication date: Available online 6 March 2020Source: Pharmacology & TherapeuticsAuthor(s): Catherine B. Meador, Aaron N. Hata (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - March 6, 2020 Category: Drugs & Pharmacology Source Type: research
Do antidepressants promote neurogenesis in adult hippocampus? A systematic review and meta-analysis on naïve rodents
Publication date: Available online 25 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Cilene Lino de Oliveira, Juliana Aparecida Bolzan, Alexandre Surget, Catherine Belzung (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
The choice for the optimal therapy in advanced biliary tract cancers: Chemotherapy, targeted therapies or immunotherapy
Publication date: Available online 25 February 2020Source: Pharmacology & TherapeuticsAuthor(s): L.-J. Palmieri, J. Lavolé, S. Dermine, C. Brezault, M. Dhooge, A. Barré, S. Chaussade, R. Coriat (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy
Publication date: Available online 26 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Lukas Gorecki, Martin Andrs, Martina Rezacova, Jan Korabecny (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Keep an eye on adenosine: Its role in retinal inflammation
Publication date: Available online 26 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Ana Raquel Santiago, Maria H. Madeira, Raquel Boia, Inês Dinis Aires, Catarina Rodrigues-Neves, Paulo Fernando Santos, António Francisco Ambrósio (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Medulloblastoma: Molecular understanding, treatment evolution, and new developments
Publication date: Available online 24 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Xiaohua Liu, Chunyong Ding, Wenfu Tan, Ao Zhang (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - February 25, 2020 Category: Drugs & Pharmacology Source Type: research
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
Publication date: Available online 24 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Concetta Schiano, Giuditta Benincasa, Monica Franzese, Nunzia Della Mura, Katia Pane, Marco Salvatore, Claudio NapoliAbstractThe complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be explained. Aberrant epigenetic changes may result from alterations in enzymatic activities, which are responsible for putting in and/or out the covalent groups, altering the epigenome and then modulating gene expression. The identification of novel individual epigenetic-sensitive trajectories at single cell level might provid...
Source: Pharmacology and Therapeutics - February 24, 2020 Category: Drugs & Pharmacology Source Type: research
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
Publication date: Available online 22 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Kimiyasu Shiraki, Tohru DaikokuAbstractFavipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing anima...
Source: Pharmacology and Therapeutics - February 24, 2020 Category: Drugs & Pharmacology Source Type: research
