The ethics of personalized medicine
Publication date: July 2014 Source:Personalized Medicine Universe, Volume 3 Author(s): Jack Kushner Personalized medicine is that branch of medicine whereby a patient's treatment and prognosis are based on his genes. Recent genetic research explains the variations and similarities between humans, their diseases, and their responses to various treatments. Because governments and universities have not set strict standards, there are numerous tests and kits available to detect genetic problems. But are these kits accurate? The validity of some biomarkers is suspect. The ethics of personalized medicine became an issue whe...
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Safety and efficacy of a dietary supplement containing functional food ingredients for erectile dysfunction
Conclusion Our initial findings support the safety of the EDiSON dietary supplement. The results from the randomized, double blind, placebo-controlled trial support the use of the EDiSON dietary supplement for the treatment of mild-to-moderate erectile dysfunction. This study was registered at http://www.umin.ac.jp, as UMIN000009405. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Adenosine exerts potent anticancer effects through diverse signaling pathways
Conclusions Adenosine exerts its anticancer action on a wide variety of cancer cell types through diverse signaling pathways. Therefore, adenosine and its signaling cascades can be useful as possible targets in the development of promising anticancer therapies. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Evaluation of the newly synthesized linoleic acid derivative DCP-LA as a potential anti-dementia drug
Conclusion DCP-LA could be developed as a promising anti-dementia drug, offering new hope for treating dementias including Alzheimer disease. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Sphingosine arrests the cell cycle and induces apoptosis by targeting sphingosine-dependent protein kinase and protein kinase Cδ in vitro
Conclusion The present review shows that sphingosine induces apoptosis and inhibits the cell cycle by targeting SDK and PKCδ. Our findings represent a fresh insight into sphingosine signaling pathways, and may provide a blueprint for developing drugs for treating Alzheimer's disease and many types of cancers. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Emerging histopathological prognostic biomarkers in hepatocellular carcinomas
Conclusion Identification of novel, effective biomarkers for the diagnosis and prognosis of HCC is critical for the improvement of companion diagnostics in personalized oncology therapies for HCC. The molecules described in this review are attractive candidates for future HCC biomarkers to be used in clinical oncology practice. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Personalized medicine for bronchial asthma and allergies
Publication date: July 2014 Source:Personalized Medicine Universe, Volume 3 Author(s): Naomi Kondo , Manami Kuwabara , Eiko Matsui , Hitomi Kodama , Masumi Kumada , Kuniyo Kondo , Tomiko Nagata , Sayuri Toida , Hiroshi Mishina , Junko Iwasaki , Yukari Matsuno , Yayoi Furuta , Akiko Shinoda , Sumio Yoshizaki , Chie Tanaka , Akiko Akita , Koutarou Taguchi , Kimiko Hirano The pathogeneses and clinical features of allergies vary greatly from patient to patient. Therefore, the establishment of individualized therapy in the form of personalized medicine is essential. We have published a guideline on persona...
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Syncope
Publication date: July 2014 Source:Personalized Medicine Universe, Volume 3 Author(s): Howard J. Kline Purpose Syncope is a common clinical problem characterized by a transient, spontaneously self-terminating loss of consciousness with complete and prompt recovery, the cause of which is insufficiency of cerebral blood flow creating generalized anoxia, most commonly due to a transient fall of systemic arterial pressure to levels below those tolerated by the cerebrovascular autoregulation mechanism. A thorough evaluation of the underlying cause of syncope is warranted in all patients to precisely diagnose the underlying...
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Personalized medicine-based strategy for prostate cancer
Publication date: July 2014 Source:Personalized Medicine Universe, Volume 3 Author(s): Akinobu Gotoh With the emergence of molecularly targeted drugs, the phrase “personalized medicine” has recently become frequently used in the medical community. This phrase basically refers to treatments based on the selection of optimum therapies for individual patients but it can also include treatments based on the integration of various new technologies to enhance clinical care. Interest in personalized medicine will likely continue to increase in the future. Given the rapid advances in molecular biology, genetic engineering...
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
