Pharmacogenetic-guided algorithms to estimate personalized dose or individual responses to anti-thrombotic drugs
Conclusions In addition to genotyping data, inter-individual variation in non-genetic factors, such as clinical laboratory data, should be considered to predict drug response more accurately in each individual. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 9, 2015 Category: Drugs & Pharmacology Source Type: research
Cancer stem cell markers in lung cancer
Conclusions CSCs have been identified in lung cancer and will provide new therapeutic targets for lung cancer. Research on these cells could improve the prognosis of lung cancer. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 9, 2015 Category: Drugs & Pharmacology Source Type: research
Repositioned alpha-1 adrenoceptor blockers as anti-tumor drugs
Discussions and conclusions Drug repositioning approaches have enabled our group and others to identify novel anti-tumor drugs. Therefore, drug repositioning can be useful in the development of promising anticancer therapies. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 8, 2015 Category: Drugs & Pharmacology Source Type: research
Safety of a Coleus forskohlii formulation in healthy volunteers
This study was registered at http://www.umin.ac.jp, as UMIN000008224. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 5, 2015 Category: Drugs & Pharmacology Source Type: research
P53 pathway and cancer: From bench to clinic
Publication date: Available online 2 May 2015 Source:Personalized Medicine Universe Author(s): Takashi Tokino , Masashi Idogawa , Yasushi Sasaki Next-generation sequencing has revealed the genomic landscapes of human cancers and has strengthened the claim that TP53 is the most frequently mutated gene in human cancers. In this review, we intend to clarify the molecular mechanisms underlying the tumor suppressive functions of p53 and understand the involvement of the p53 signaling pathway in tumorigenesis. One of the major goals of this review is to guide the development of more effective approaches for reducing cance...
Source: Personalized Medicine Universe - May 2, 2015 Category: Drugs & Pharmacology Source Type: research
Gliomas and genomics
Publication date: Available online 2 May 2015 Source:Personalized Medicine Universe Author(s): Jack Kushner (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 2, 2015 Category: Drugs & Pharmacology Source Type: research
Molecular genetics of coronary artery disease and ischemic stroke
Publication date: Available online 30 April 2015 Source:Personalized Medicine Universe Author(s): Yoshiji Yamada Coronary artery disease (CAD) and ischemic stroke are important clinical problems because they are associated with high mortality rates. The main causal and treatable risk factors of CAD and ischemic stroke include hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, and smoking. In addition, recent studies have highlighted the importance of genetic factors and their interactions with environmental factors in the development of CAD and ischemic stroke. Disease prevention is an important st...
Source: Personalized Medicine Universe - May 1, 2015 Category: Drugs & Pharmacology Source Type: research
Medical treatment of food allergies should be personalized
Publication date: Available online 30 April 2015 Source:Personalized Medicine Universe Author(s): Naomi Kondo , Manami Kuwabara , Hitomi Kodama , Masumi Kumada , Nobuhiro Hori (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 1, 2015 Category: Drugs & Pharmacology Source Type: research
A patient with stage IV gastric cancer who acquired complete remission after undergoing multi-peptide dendritic cell immunotherapy in combination with standard therapies
In conclusion, multi-peptide dendritic cell immunotherapy in combination with conventional therapies resulted in remarkable anti-cancer effects and improved the patient's quality of life. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - April 29, 2015 Category: Drugs & Pharmacology Source Type: research
A patient-centered model of the action of psychotropic drugs
Conclusion The patient-centered model proposed in this paper, though provisional, provides a broad-based, unified framework for understanding the actions of psychotropic drugs, and can enhance clinical practice and research. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - April 16, 2015 Category: Drugs & Pharmacology Source Type: research
Jidabokuippo use in patients with fractures of the extremities
Conclusion This study suggests that JDI can be used more widely for fractures of the extremities. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - March 20, 2015 Category: Drugs & Pharmacology Source Type: research
Hybrid ensemble learning technique for screening of cervical cancer using Papanicolaou smear image analysis
Publication date: Available online 7 March 2015 Source:Personalized Medicine Universe Author(s): Abid Sarwar , Vinod Sharma , Rajeev Gupta Objective This paper presents an innovative idea of applying a hybrid ensemble technique i.e. ensemble of ensemble methods for improving the predictive performance of Artificial intelligence based system for screening of cervical cancer by characterization and classification of Pap smear images. Methodology Papanicolaou smear (also referred to as Pap smear) is a microscopic examination of samples of human cells scraped from the lower, narrow part of the uterus, called the cervi...
Source: Personalized Medicine Universe - March 7, 2015 Category: Drugs & Pharmacology Source Type: research
Development of a smartphone-based diabetes self-care management system
Publication date: July 2012 Source:Personalized Medicine Universe, Volume 1, Issue 1 Author(s): Sang Youl Rhee , Jeong-taek Woo , Young Seol Kim , Young Kil Choi (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Seeing schizophrenia through a personalized medicine prism
Publication date: July 2012 Source:Personalized Medicine Universe, Volume 1, Issue 1 Author(s): Isaac L. Michael Lesser (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
System lupus erythematosis and mercury toxicity
Publication date: July 2012 Source:Personalized Medicine Universe, Volume 1, Issue 1 Author(s): John P. Salerno This case study examines the relationship between heavy metal toxicity and its influence on auto immune disease. In the traditional medical world almost all auto immune diseases are classified as idiopathic. In my clinical experience with hundreds of auto immune disease patients, it is increasingly clear that environmental influences particularly heavy metals and most commonly mercury is a major causative agent. This case study is not uncommon and the effect of mercury on immune disregulation is well documen...
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
