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Pediatric Diabetes, Ahead of Print. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Source Type: research
Neutropenia in 6 cases of childhood onset type 1 diabetes and its possible mechanisms
ConclusionNeutropenia can be seen in childhood onset T1D, and can return spontaneously to normal range without special treatments. The possible mechanisms might be the regulation effects of insulin on G‐CSF and GM‐CSF. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Authors: Jieyuan Cui, Chunzhen Li, Lin Zhang Tags: ORIGINAL ARTICLE Source Type: research
IL7RA haplotypes differentially affect soluble IL ‐7 receptor and IL‐7 serum concentrations in children with type 1 diabetes
Interleukin‐7 receptor α‐chain (IL7RA) haplotypes are associated with susceptibility for development of autoimmune diseases including Type 1 Diabetes (T1D). A protective IL7RA haplotype which causes lower soluble IL‐7R (sIL‐7R) serum levels is hypothesized to restrict IL‐7‐availability for self‐reactive T‐cells. Functional mechanisms affected by a risk‐associated IL7RA haplotype are unknown.
Here we investigated the influence of IL7RA haplotypes (tagged by rs6897932T for the protective or by rs1494555G for the risk haplotype) on sIL‐7R and IL‐7 serum concentrations as well as disease manifestation of...
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Authors: Julia Seyfarth, Christian Lundtoft, Katharina F örtsch, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W. Holl, Ertan Mayatepek, Sebastian Kummer, Thomas Meissner, Marc Jacobsen Tags: ORIGINAL ARTICLE Source Type: research
Diabetic ketoacidosis incidence in children at first presentation of type 1 diabetes at an Australian regional hospital: the effect of health professional education
ConclusionsDKA incidence at first presentation of type 1 diabetes prior to intervention, is higher than that reported by other studies in Australia: Brisbane (31.8%) and Sydney (37.7%). DKA incidence at first presentation of type 1 diabetes decreased significantly during the period of health professional education. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Authors: Radhika Patwardhan, Susan Gorton, Venkat N Vangaveti, Jason Yates Tags: ORIGINAL ARTICLE Source Type: research
High frequencies of dermatological complications in children using insulin pumps or sensors
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 26, 2018 Category: Endocrinology Source Type: research
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Pediatric Diabetes, Ahead of Print. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 26, 2018 Category: Endocrinology Source Type: research
High frequencies of dermatological complications in children using insulin pumps or sensors
ConclusionsDermatological complications can be a serious problem in treating pediatric and adolescent patients of all ages with CSII and/or CGM. Only a few clinical characteristics associated with these complications were identified in this study, highlighting the need for prospective studies that might lead to improvements in the prevention and treatment of dermatological problems. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 26, 2018 Category: Endocrinology Authors: Anna Korsgaard Berg, Birthe Susanne Olsen, Jacob P Thyssen, Claus Zachariae, Anne Birgitte Simonsen, Kasper Pilgaard, Jannet Svensson Tags: ORIGINAL ARTICLE Source Type: research
Alpha ‐1 antitrypsin treatment of new‐onset type 1 diabetes: an open‐label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics
CONCLUSIONSAAT was well tolerated and safe in subjects with new‐onset type 1 diabetes. Weekly doses of AAT greater than 90 mg/kg may be necessary for an optimal therapeutic effect. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 23, 2018 Category: Endocrinology Authors: Gordon C. Weir, Mario R. Ehlers, Kristina M. Harris, Sai Kanaparthi, Alice Long, Deborah Phippard, Lia J. Weiner, Brett Jepson, James G. McNamara, Maria Koulmanda, Terry B. Strom, Tags: ORIGINAL ARTICLE Source Type: research
Factitious hypoglycemia in children and adolescents with diabetes
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 21, 2018 Category: Endocrinology Source Type: research
Intensive remote monitoring versus conventional care in type 1 diabetes: A randomized controlled trial
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 21, 2018 Category: Endocrinology Source Type: research
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Pediatric Diabetes, Ahead of Print. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 21, 2018 Category: Endocrinology Source Type: research
Intensive remote monitoring versus conventional care in type 1 diabetes: A randomized controlled trial
ConclusionsIRT substantially affected diabetes metrics and improved QoL among pediatric patients with T1D. Adolescents experienced a stronger treatment effect, but had difficulty in sustaining improved control after intervention cessation. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 21, 2018 Category: Endocrinology Authors: Laura Gandrud, Aylin Altan, Paul Buzinec, Jesse Hemphill, Jayne Chatterton, Tina Kelley, Deneen Vojta Tags: ORIGINAL ARTICLE Source Type: research
Factitious hypoglycemia in children and adolescents with diabetes
ConclusionsFactitious hypoglycemia typically occurs in adolescents with type 1 diabetes who use insulin to induce hypoglycemia. Awareness of this differential diagnosis and knowledge of potentially misleading laboratory results may facilitate earlier recognition and intervention. Little information exists on effective treatments and long‐term outcome. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 21, 2018 Category: Endocrinology Authors: Viviana Bauman, Adaya C Sturkey, Rosa Sherafat ‐Kazemzadeh, Jennifer McEwan, Paul M Jones, Ashley Keating, Elvira Isganaitis, Alyne Ricker, Kristina I Rother Tags: REVIEW ARTICLE Source Type: research
A plateau in new onset type 1 diabetes: Incidence of pediatric diabetes in the United States Military Health System
ConclusionsThe incidence of type 1 diabetes among children appears to plateau during the study period, suggesting a steady state of type 1 diabetes within this pediatric population. The MHS provides an accurate and up to date look at incidence of type 1 diabetes and may reflect broader trends of incidence of pediatric disease for the U.S. as a whole. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 15, 2018 Category: Endocrinology Authors: Toni Rush, Megan McGeary, Nicholas Sicignano, Melissa A. Buryk Tags: ORIGINAL ARTICLE Source Type: research
