Severe hypoglycemia and diabetic ketoacidosis in young persons with preschool onset of type 1 diabetes mellitus: An analysis of three nationwide population ‐based surveys
ConclusionsAfter adjustment, rates of SH and SH‐ or DKA‐associated hospitalization showed no significant changes in recent years. Structured education programs focusing on high‐risk groups as, for example, persons with T1D living with 1 biological parent and the parents’ partner or those with a low SES, should be implemented to reduce incidence rates of hospitalizations. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 2, 2018 Category: Endocrinology Authors: Lena M E Lindner, Veronika Gontscharuk, Christina B ächle, Katty Castillo, Anna Stahl‐Pehe, Thaddäus Tönnies, Rhuphine Yossa, Reinhard W Holl, Joachim Rosenbauer Tags: ORIGINAL ARTICLE Source Type: research
Type 1 diabetes, sport practiced, and ankle joint mobility in young patients: What is the relationship?
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Source Type: research
Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Source Type: research
Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Source Type: research
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Pediatric Diabetes, Ahead of Print. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Source Type: research
Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: a longitudinal study
Conclusions/interpretationOur data suggest an association between immune cells, cytokine patterns and metabolic counterparts. The dynamic changes of circulating immune cells during disease progression involve key innate and acquired immune cell types. This longitudinal picture of T1D progression may enable disease staging and patient stratification, essential for individualized treatment. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Ana Laura Fitas, Catarina Martins, Lu ís Miguel Borrego, Lurdes Lopes, Anne Jörns, Sigurd Lenzen, Catarina Limbert Tags: ORIGINAL ARTICLE Source Type: research
Permanent neonatal diabetes mellitus and neurological abnormalities due to a novel homozygous missense mutation in NEUROD1
The basic helix‐loop‐helix(bHLH) transcription factor, NEUROD1(also known as BETA2) is involved in the development of neural elements and endocrine pancreas. Less than 10 reports of adult‐onset non‐insulin dependent diabetes mellitus(NIDDM) due to heterozygous NEUROD1 mutations and two cases with permanent neonatal diabetes mellitus(PNDM) and neurological abnormalities due to homozygous NEUROD1 mutations have been published. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Huseyin Demirbilek, Nihal Hatipoglu, Ulku Gul, Zeynep Uzan Tatli, Sian Ellard, Sarah E. Flanagan, Elisa De Franco, Selim Kurtoglu Tags: CASE REPORT Source Type: research
A phase 3 multicenter, open ‐label, prospective study designed to evaluate the effectiveness and ease of use of nasal glucagon in the treatment of moderate and severe hypoglycemia in children and adolescents with type 1 diabetes in the home or school setting
CONCLUSIONSA single 3‐mg dose of NG was effective in treating moderate, symptomatic, hypoglycemic events in children and adolescents with T1D in a real‐world setting. It was easy to use and reasonably well tolerated. NG shows promise as an effective, needle‐free, and user‐friendly alternative to injectable glucagon. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Larry C. Deeb, H élène Dulude, Cristina B. Guzman, Shuyu Zhang, Barry J. Reiner, Claude A. Piché, Sheetal Pradhan, Xiaotian Michelle Zhang Tags: ORIGINAL ARTICLE Source Type: research
Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease
ConclusionsIndividuals with the dual diagnoses of T1DM and CD have an increased likelihood to develop DEBs compared to those with only one of these diagnoses. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Itay Tokatly Latzer, Marianna Rachmiel, Nehama Zuckerman Levin, Kineret Mazor ‐Aronovitch, Zohar Landau, Rachel Frumkin Ben‐David, Chana GrafBar‐El, Noah Gruber, Noa Levek, Batia Weiss, Daniel Stein, Liat Lerner‐Geva, Orit Pinhas‐Hamiel Tags: ORIGINAL ARTICLE Source Type: research
Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations
ConclusionsGiven the heterogeneous clinical phenotypes of HNF1A‐ and HNF4A‐HI, all children with transient, diazoxide‐responsive HI without clear history of perinatal stress, should be screened for HNF1A and HNF4A mutations as it predicts the clinical course and affects the subsequent management plan. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Joanna Yuet ‐ling Tung, Kara Boodhansingh, Charles A Stanley, Diva D De León Tags: ORIGINAL ARTICLE Source Type: research
Type 1 diabetes, sport practiced, and ankle joint mobility in young patients: What is the relationship?
ConclusionsThe results of this study, in addition to confirming the negative effect of diabetes on AJM of young T1D patients, suggest that during these evaluations the sport‐related effect should be considered because it can induce significant changes of AJM. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - March 1, 2018 Category: Endocrinology Authors: Piergiorgio Francia, Sonia Toni, Giulia Iannone, Giuseppe Seghieri, Barbara Piccini, Alessandro Vittori, Ugo Santosuosso, Emilio Casalini, Massimo Gulisano Tags: ORIGINAL ARTICLE Source Type: research
Brain Injury Markers: S100 calcium ‐binding protein B, Neuron‐Specific Enolase and Glial Fibrillary Acidic Protein in Children with Diabetic Ketoacidosis
ConclusionNSE and GFAP levels do not increase in DKA patients without overt brain injury. Elevated levels of S100B, which is also synthesized from non‐neuronal tissues, might arise from peripheral sources. A lack of concurrent increase in serum levels of these brain injury markers might result from the yet intact blood brain barrier or a true absence of neuronal damage. In order to reveal subclinical brain injury related to DKA, there is a need for studies concurrently assessing neurocognitive functions. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Authors: G önül Çatlı, Ahmet Anık, Sezer Acar, Tuncay Küme, Melike Karabulut, Özlem Gürsoy Çalan, Bumin Nuri Dündar, Ayhan Abacı Tags: ORIGINAL ARTICLE Source Type: research
Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Source Type: research
