The contribution of physical fitness to individual and ethnic differences in risk markers for type 2 diabetes in children: The Child Heart and Health Study in England (CHASE)
ConclusionsPhysical fitness is associated with risk markers for T2D and CVD in children, which persist after adjustment for adiposity. Higher levels of IR in South Asians are partially explained by lower physical fitness levels compared to white Europeans. Improving physical fitness may provide scope for reducing risks of T2D. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 7, 2018 Category: Endocrinology Authors: Claire M Nightingale, Alicja R Rudnicka, Sarah R Kerry ‐Barnard, Angela S Donin, Soren Brage, Kate L Westgate, Ulf Ekelund, Derek G Cook, Christopher G Owen, Peter H Whincup Tags: ORIGINAL ARTICLE Source Type: research
Beta Cell Function after Intensive Subcutaneous Insulin Therapy or Intravenous Insulin Infusion at Onset of T1D in Children without ketoacidosis
ConclusionResidual beta cell function at 2 years seems to be independent from initial insulin regimens but related to HbA1c and c‐peptide at onset. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 1, 2018 Category: Endocrinology Authors: Rebecka Enander, Peter Adolfsson, Torun Bergdahl, Gun Forsander, Johnny Ludvigsson, Ragnar Hanas Tags: ORIGINAL ARTICLE Source Type: research
Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicentre DPV study on 24,011 patients from Germany, Austria, or Luxembourg
ConclusionsOC use in adolescent girls with type 1 diabetes was associated with a poorer cardiovascular risk profile. Biological risk factors were partly explained by a clustering of sociodemographic and lifestyle factors with a small additional contribution of OC use. Prescription of OC should therefore be combined with a screening for cardiovascular risk factors and targeted education. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 1, 2018 Category: Endocrinology Authors: Barbara Bohn, Kirsten M önkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W. Holl, Tags: ORIGINAL ARTICLE Source Type: research
Higher body mass index predicts cardiac autonomic dysfunction: A longitudinal study in adolescent type 1 diabetes
ConclusionsHigher BMI and central adiposity are associated with cardiac autonomic dysfunction in childhood onset type 1 diabetes, after adjusting for HbA1c. Interventions targeting overweight/obesity during adolescence may optimize long‐term vascular health in type 1 diabetes. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Authors: Yoon H Cho, Maria E Craig, Tracey Jopling, Albert Chan, Kim C Donaghue Tags: ORIGINAL ARTICLE Source Type: research
Higher body mass index predicts cardiac autonomic dysfunction: A longitudinal study in adolescent type 1 diabetes
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Source Type: research
Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Source Type: research
Diabetes distress is more strongly associated with HbA1c than depressive symptoms in adolescents with type 1 diabetes: Results from Diabetes MILES Youth —Australia
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Source Type: research
Effects of insulin resistance on the association between the circulating retinol ‐binding protein 4 level and clustering of pediatric cardiometabolic risk factors
Pediatric Diabetes, EarlyView. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Source Type: research
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Pediatric Diabetes, Ahead of Print. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Source Type: research
Diabetes distress is more strongly associated with HbA1c than depressive symptoms in adolescents with type 1 diabetes: Results from Diabetes MILES Youth —Australia
ConclusionsConsistent with evidence from studies among adults, diabetes distress mediated the relationship between depressive symptoms and HbA1c among adolescents with type 1 diabetes. These findings suggest that clinicians need to be aware of diabetes distress. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Authors: Virginia Hagger, Christel Hendrieckx, Fergus Cameron, Frans Pouwer, Timothy C Skinner, Jane Speight Tags: ORIGINAL ARTICLE Source Type: research
Effects of insulin resistance on the association between the circulating retinol ‐binding protein 4 level and clustering of pediatric cardiometabolic risk factors
ConclusionsHOMA‐IR is associated with the circulating RBP4 level and cardiometabolic risk factors in adolescents. Pediatric HOMA‐IR may have mediating and modifying effects on the positive correlations between RBP4 and the clustering of MetS components. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Authors: Wei ‐Ting Lin, Pei‐Chen Lin, Chun‐Ying Lee, Yi‐Ling Chen, Te‐Fu Chan, Sharon Tsai, Hsiao‐Ling Huang, Pei‐Wen Wu, Yu‐Ting Chin, Hui‐Yi Lin, Chien‐Hung Lee Tags: ORIGINAL ARTICLE Source Type: research
Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan
ConclusionIn addition to clarifying the roles of several known T1D HLA alleles and haplotypes, we discovered that the DRB1*08:03‐DQB1*06:01 haplotype is protective against T1D. The DRB1*12:02 allele protected against both T1D and Graves’ disease. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - January 31, 2018 Category: Endocrinology Authors: Yi ‐Ching Tung, Cathy S‐J Fann, Chien‐Ching Chang, Chen‐Chung Chu, Wei‐Shiung Yang, Wuh‐Liang Hwu, Pei‐Lung Chen, Wen‐Yu Tsai Tags: ORIGINAL ARTICLE Source Type: research
