Brain Injury Markers: S100 calcium ‐binding protein B, Neuron‐Specific Enolase and Glial Fibrillary Acidic Protein in Children with Diabetic Ketoacidosis

ConclusionNSE and GFAP levels do not increase in DKA patients without overt brain injury. Elevated levels of S100B, which is also synthesized from non‐neuronal tissues, might arise from peripheral sources. A lack of concurrent increase in serum levels of these brain injury markers might result from the yet intact blood brain barrier or a true absence of neuronal damage. In order to reveal subclinical brain injury related to DKA, there is a need for studies concurrently assessing neurocognitive functions.

Source: Pediatric Diabetes - February 27, 2018 Category: Endocrinology Authors: G önül Çatlı, Ahmet Anık, Sezer Acar, Tuncay Küme, Melike Karabulut, Özlem Gürsoy Çalan, Bumin Nuri Dündar, Ayhan Abacı Tags: ORIGINAL ARTICLE Source Type: research