Centre ‐level variation of treatment and outcome in 5‐year‐old children with non‐syndromic unilateral cleft lip and palate: The Cleft Care UK study. Part 1: Methodology and results for dento‐facial outcomes
ConclusionsThere was no evidence of centre‐level variation for dento‐facial outcomes although this study only had the power to detect large variation between sites. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 29, 2017 Category: Dentistry Authors: A. K. Wills, O. Mahmoud, A. Hall, D. Sell, J. Smallridge, L. Southby, S. Toms, A. Waylen, Y. Wren, A. R. Ness, J. R. Sandy Tags: ORIGINAL ARTICLE Source Type: research

CO2 low ‐level laser therapy has an early but not delayed pain effect during experimental tooth movement
ConclusionLow‐level laser therapy may reduce early neurochemical markers but have no effect on delayed pain neurochemical markers after tooth movement. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: T. Deguchi, DG. Kim, H. Kamioka Tags: ORIGINAL ARTICLE Source Type: research

Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice
ConclusionIn summary, estrogen plays a role in mediating mandibular condylar maturation in young male mice. However, according to this study, it does not play a role in mediating long‐term growth or age‐related mandibular condylar cartilage degeneration in males. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: J. L. Robinson, V. Gupta, P. Soria, E. Clanaman, S. Gurbarg, M. Xu, J. Chen, S. Wadhwa Tags: ORIGINAL ARTICLE Source Type: research

PTH [1 ‐34]‐induced alterations predispose the mandibular condylar cartilage to mineralization
ConclusionsIntermittent PTH [1‐34] results in early mineralization of the MCC, which may result in cartilage degeneration. Our results identified a novel mechanism by which PTH [1‐34] induces alteration in the microarchitecture of the MCC and the subchondral bone. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: E. H. Dutra, M. H. O'Brien, T. Gutierrez, A Lima, R. Nanda, S. Yadav Tags: ORIGINAL ARTICLE Source Type: research

Effects of cocoa ‐enriched diet on orofacial pain in a murine model
ConclusionUsing the OPAD operant system, we demonstrated that a diet rich in cocoa was effective in inhibiting neurogenic inflammatory pain in rats. This has implications for the use of novel alternative therapies such as diet modification for pain control. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: L. N. Bowden, E. L. Rohrs, K. Omoto, P. L. Durham, L. S. Holliday, A. D. Morris, K. D. Allen, R. M. Caudle, J. K. Neubert Tags: ORIGINAL ARTICLE Source Type: research

Fluid pressurization and tractional forces during TMJ disc loading: A biphasic finite element analysis
ConclusionSustained mechanical loading may play a role in load carriage within the ECM and ploughing force formation during stress‐field translation at the condyle–disc interface. This study further elucidated the mechanism of ploughing on tractional force formation and provided a baseline for future analysis of TMJ mechanics, cartilage fatigue and early TMJ degeneration. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: Y. Wu, S. E. Cisewski, F. Wei, X. She, T. S. Gonzales, L. R. Iwasaki, J. C. Nickel, H. Yao Tags: ORIGINAL ARTICLE Source Type: research

Jaw mechanics in dolichofacial and brachyfacial phenotypes: A longitudinal cephalometric ‐based study
ConclusionsCraniofacial mechanics may explain, in part, mandibular growth differences between dolichofacial and brachyfacial phenotypes. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: L. R. Iwasaki, Y. Liu, H. Liu, J. C. Nickel Tags: ORIGINAL ARTICLE Source Type: research

Mechanobehaviour in dolichofacial and brachyfacial adolescents
ConclusionsMechanobehaviour showed significant differences between facial types and was correlated with ramus height. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: J. C. Nickel, A. L. Weber, P. Covington Riddle, Y. Liu, H. Liu, L. R. Iwasaki Tags: ORIGINAL ARTICLE Source Type: research

In vitro evaluation of surface properties of Pro Seal ® and Opal® SealTM in preventing white spot lesions
ConclusionF release was adequate to aid in remineralization, although clinically it would not likely aid in preventing demineralization as there was no prolonged release of F by both sealants tested. S. mutans adherence to OS surface was less compared to PS surface, which could be of relevance in biofilm formation and white spot lesions. Both sealants protected enamel surfaces from acid penetration. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: T. S. Premaraj, N. Rohani, D. Covey, S. Premaraj Tags: ORIGINAL ARTICLE Source Type: research

Clinical effectiveness of late maxillary protraction in cleft lip and palate: A methods paper
ConclusionThis observational trial is collecting information that will examine dental, skeletal, financial and quality‐of‐life issues from both research cohorts. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: M. K. Lee, C. Lane, F. Azeredo, M. Landsberger, H. Kapadia, B. Sheller, S. L. Yen Tags: ORIGINAL ARTICLE Source Type: research

A new cyte in orthodontics: Osteocytes in tooth movement
Abstract Orthodontic tooth movement (OTM) relies on the orchestration of clinical and biologic events that include the application of clinical force followed by a cascade of cellular and molecular responses. Our understanding about OTM today has evolved from, and is largely based on historic studies. However, the advances in bone biology and clinical orthodontics today continue to pave the pathway towards an improved knowledge base, and state of the art therapeutics in OTM. Osteoblasts and osteoclasts have been the primary cells analyzed in OTM. However, the role of osteocytes, a cell previously thought to be static, shoul...
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: E. E. Bumann, S. A. Frazier ‐Bowers Tags: REVIEW ARTICLE Source Type: research

Evaluation of the 3dMDface system as a tool for soft tissue analysis
ConclusionsMeasurements on a mannequin confirmed the accuracy of all landmarks and parameters analysed in this study using the 3dMDface system. Results indicated that 3dMDface system is an accurate tool for linear and surface measurements, with potentially broad‐reaching applications in orthodontics, surgical treatment planning and treatment evaluation. (Source: Orthodontics and Craniofacial Research)
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: C. Hong, K. Choi, Y. Kachroo, T. Kwon, A. Nguyen, R. McComb, W. Moon Tags: ORIGINAL ARTICLE Source Type: research

Utilizing three ‐dimensional data in orthodontic practice and research
Abstract The recent prevalence of three dimensional (3D) images of soft and hard tissues provides a wealth of new data from which the clinician can evaluate these changes. However, evaluating this new data presents new and significant challenges. Current approaches utilizing multi‐dimensional data for the precise evaluation of changes related to treatment and growth sets are reviewed. The results of current validation studies exploring approaches to these problems are reviewed, including the registration of longitudinal data using maxillary and mandibular regions of reference. Challenges related to the consistent selecti...
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: R. C. Solem Tags: REVIEW ARTICLE Source Type: research

Moving towards precision orthodontics: An evolving paradigm shift in the planning and delivery of customized orthodontic therapy
Abstract Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and likely future applications to precision orthodontics. A review of orthodontically relevant technologies and advances in pertinent biological research was undertaken. Innovations in computer hardware and software, and 3D imaging technologies offer the ability for customized treatment and biomechanical pla...
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: A. H. Jheon, S. Oberoi, R. C. Solem, S. Kapila Tags: REVIEW ARTICLE Source Type: research

Micro ‐anatomical responses in periodontal complexes of mice to calibrated orthodontic forces on the crown
ConclusionsThis novel approach illustrates the importance of 3D‐imaging and analysing 3D alveolar socket subjected to OTM otherwise omitted by 2D micrographs. A measured force on the crown elicits a response related to narrowed and widened regions in the 3D complex. OTM that exceeds PDL‐space can illicit biological responses that attempt to restore physiologic PDL‐space via remodelling of the periodontium. Regenerated weaker bone due to aseptic inflammation caused by orthodontics could leave patients at a higher risk of bone loss or root resorption if they later develop periodontitis, a form of septic inflammation. ...
Source: Orthodontics and Craniofacial Research - June 23, 2017 Category: Dentistry Authors: A. Pal, L. Chen, L. Yang, F. Yang, B. Meng, A. H. Jheon, S. P. Ho Tags: ORIGINAL ARTICLE Source Type: research