Corrigendum to “Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway” [Oral Oncol. 76 (2018) 34–41]
The authors regret that the affiliation details for Wanjun Chen appeared incorrectly. The correct affiliation should appear as above: (Source: Oral Oncology)
Source: Oral Oncology - February 3, 2018 Category: Cancer & Oncology Authors: Yingnan Wang, Xing Qin, Xueqin Zhu, Wanjun Chen, Jianjun Zhang, Wantao Chen Tags: Corrigendum Source Type: research
Double positivity for HPV-DNA/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
About a decade ago the International Agency for Research on Cancer (IARC) established high-risk Human papillomavirus 16 (HPV16) as a cause of oropharyngeal carcinoma (OPC) [1]. Since then, increasing amount of information on the role of HPVs in OPC has been generated. The IARC estimates that approximately 29,000 new HPV-related OPC cases occur every year, corresponding to 31% of the worldwide number of the overall incident OPC cases [2]. These estimates, as well as previous meta-analyses assessing the quantitative contribution of HPV, found high geographic heterogeneity in HPV-attributable fractions (AFs) of OPC, ranging f...
Source: Oral Oncology - February 2, 2018 Category: Cancer & Oncology Authors: Marisa Mena, Miren Taberna, Sara Tous, Sandra Marquez, Omar Clavero, Beatriz Quiros, Belen Lloveras, Maria Alejo, Xavier Leon, Miquel Quer, Silvia Bagu é, Ricard Mesia, Julio Nogués, Montserrat Gomà, Anton Aguila, Teresa Bonfill, Carmen Blazquez, Marta Source Type: research
Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target
Over 14 million new cancer cases are diagnosed each year, which kill a person about every 5 seconds around the world [4]. These statistics indicate that many cancers are not treated successfully. Oral cancer has earned its place among the world’s most vicious malignancies. Oral cancer kills over 8,00 0 people in the USA and 140,000 people worldwide every year, and these numbers are rising [5,6]. (Source: Oral Oncology)
Source: Oral Oncology - February 2, 2018 Category: Cancer & Oncology Authors: Edward P. Retzbach, Stephanie A. Sheehan, Evan M. Nevel, Amber Batra, Tran Phi, Angels T.P. Nguyen, Yukinari Kato, Soly Baredes, Mahnaz Fatahzadeh, Alan J. Shienbaum, Gary S. Goldberg Tags: Review Source Type: research
Pitfalls of post-treatment PET after de-intensified chemoradiotherapy for HPV-associated oropharynx cancer: Secondary analysis of a phase 2 trial
The management of the neck after definitive chemoradiation (CRT) for oropharynx cancer has evolved from planned neck dissection for all patients towards imaging-based surveillance, reserving neck dissection only for those with concern for residual disease. The safety of this approach was recently confirmed by Mehanna et al. in a large randomized trial showing equivalent survival, better quality of life [1], and higher cost-effectiveness [2] in patients with N2 disease randomized to surveillance PET vs. (Source: Oral Oncology)
Source: Oral Oncology - February 1, 2018 Category: Cancer & Oncology Authors: Kyle Wang, Terence Z. Wong, Robert J. Amdur, William M. Mendenhall, Nathan C. Sheets, Rebecca Green, Brian D. Thorp, Samip N. Patel, Trevor G. Hackman, Adam M. Zanation, Mark C. Weissler, Bhishamjit S. Chera Source Type: research
Comparison between magnetic resonance and computed tomography in detecting mandibular invasion in oral cancer: A systematic review and diagnostic meta-analysis
Oral cavity cancer is characterized as an aggressive tumor with a high rate of locoregional spread and initial presentation at advanced stage in the majority of cases, particularly in developing countries [1,2]. Mandibular erosion, extension to posterior soft tissue and perineural invasion have an impact on treatment and prognosis in oral cancer. Information from imaging helps with accurate staging, assessment of resectability and aids in planning multimodal treatment [3]. (Source: Oral Oncology)
Source: Oral Oncology - February 1, 2018 Category: Cancer & Oncology Authors: Jos é de Souza Brandão Neto, Felipe Toyama Aires, Rogério Aparecido Dedivitis, Leandro Luongo Matos, Claudio Roberto Cernea Source Type: research
Characterization of epithelial oral dysplasia in non-smokers: First steps towards precision medicine
Tobacco usage is the strongest risk factor for the development of oral squamous cell carcinoma (OSCC) [1 –4], which mandates careful screening for oral cancers in smokers. However, OSCC does develop in non-smokers (NS), and there are indications that oral potentially malignant lesions (OPML) in NS possess a higher cancer risk than those in smokers [5–8]. Without tobacco as an etiology, the developm ent of these lesions in NS may suggest genetic susceptibility. Tobacco cessation efforts have resulted in a drop in oral cancer rates associated with this habit [9], leading to a growing interest in the increased proportion ...
Source: Oral Oncology - February 1, 2018 Category: Cancer & Oncology Authors: L.D. Rock, M.P. Rosin, L. Zhang, B. Chan, B. Shariati, D.M. Laronde Source Type: research
Combination of post-operative radiotherapy and cetuximab for high-risk cutaneous squamous cell cancer of the head and neck: A propensity score analysis
Non-melanoma skin cancer is the most common human malignancy and the incidence of these cancers continues to rise [1]. Cutaneous squamous cell carcinomas (CSCC) make up approximately 20 –30% of all skin cancers. The incidence among elderly (>65 years) is approximately 4–8 times higher than younger persons. Although the vast majority of these cancers portend an excellent prognosis, some high risk CSSC may recur or metastasize [2]. The regional lymph nodes are the most common site of metastasis (85%) and despite aggressive therapy porte nds a dismal 5-year overall survival between 14 and 39% [3]. (Source: Oral Oncology)
Source: Oral Oncology - January 31, 2018 Category: Cancer & Oncology Authors: Joshua D. Palmer, Charles J. Schneider, Neil Hockstein, Alexandra L. Hanlon, Jordan Silberg, Jon Strasser, Elizabeth A. Mauer, Michael Dzeda, Robert Witt, Adam Raben Source Type: research
Role of sequential chemoradiotherapy in stage II and low-risk stage III –IV nasopharyngeal carcinoma in the era of intensity-modulated radiotherapy: A propensity score-matched analysis
To investigate the role of sequential chemoradiotherapy (SCRT; induction chemotherapy [IC] followed by intensity-modulated radiotherapy [IMRT]) in stage II and low-risk stage III –IV nasopharyngeal carcinoma (NPC). (Source: Oral Oncology)
Source: Oral Oncology - January 29, 2018 Category: Cancer & Oncology Authors: Cheng Xu, Rui Sun, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Guan-Qun Zhou, Rui Guo, Ai-Hua Lin, Ying Sun, Jun Ma, Wei-Han Hu Source Type: research
Prognostic significance and optimal candidates of primary tumor resection in major salivary gland carcinoma patients with distant metastases at initial presentation: A population-based study
Major salivary gland carcinoma (MaSGC) constitutes less than 5% of all head and neck malignancies but consists of more than 20 histologic types with heterogeneous clinical presentation, biological behavior and prognosis according to the WHO classification updated in 2005 [1,2]. Distant metastasis, although relatively uncommon, is regarded as one of the most frequent failures and a significant concern in the management of MaSGC [3]. In the up-to-date NCCN guideline, chemotherapy, expectant management, selected metastasectomy and best supportive care remain the only management approaches for patients with metastatic MaSGC at...
Source: Oral Oncology - January 29, 2018 Category: Cancer & Oncology Authors: Xiao Shi, Fan Dong, Wenjun Wei, Kehan Song, Naisi Huang, Zhongwu Lu, Bowen Lei, Pengcheng Yu, Wanlin Liu, Yu Wang, Guohua Sun, Yulong Wang, Qinghai Ji Source Type: research
Identification of a gene expression signature predicting survival in oral cavity squamous cell carcinoma using Monte Carlo cross validation
Head and neck cancers are cancers of the upper airway and/or digestive tract found in the oral cavity, laryngeal, pharyngeal, oropharyngeal, and hypo-pharyngeal tissues. Head and neck cancers make up 3% of cancers diagnosed each year [1,2]. Head and neck cancer incidence has declined from 25 cases per 100,000 at risk in the 1990s to 15 cases per 100,000 at risk in the present day [3]. While the decrease in head and neck cancer incidence may be due to a drop in tobacco use [4,5], the mortality associated with these cancers has not changed significantly in the last twenty years [6]. (Source: Oral Oncology)
Source: Oral Oncology - January 27, 2018 Category: Cancer & Oncology Authors: John Schomberg, Argyrios Ziogas, Hoda Anton-Culver, Trina Norden-Krichmar Source Type: research
Refining the eighth edition AJCC TNM classification and prognostic groups for papillary thyroid cancer with lateral nodal metastasis
Papillary thyroid cancer (PTC) is one of the most common cancers, with an incidence rate that continues to rise annually. The cancer is usually indolent with excellent prognosis, but cases with lateral nodal metastasis (N1b) require extended neck surgery and are considered to have relatively poor prognosis [1 –3]. In the seventh American Joint Committee on Cancer (AJCC) TNM staging system, all N1b patients 45 years or older were classified as stage IV regardless of other factors [4,5], and the mortality risk of N1b was therefore exaggerated [6]. (Source: Oral Oncology)
Source: Oral Oncology - January 27, 2018 Category: Cancer & Oncology Authors: Hye In Kim, Kyunga Kim, So Young Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Hyeon Seon Ahn, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung Source Type: research
Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers?
Oral cavity squamous cell cancer (OCSCC) accounts for 3.8% of all cancer cases and is responsible for 3.6% of cancer deaths worldwide [1]. A unique characteristic of the oral cavity is the presence of multiple subsites within it. Though anatomically congruent, these sites have specific characteristics as far as potentially malignant disorders and tumor spread are concerned [2]. The two most commonly involved subsites of the oral cavity are the oral tongue, more common in North America and Europe, and the lower gingivobuccal complex, more common in Southeast Asia [3]. (Source: Oral Oncology)
Source: Oral Oncology - January 26, 2018 Category: Cancer & Oncology Authors: Piyush Gupta, Jocelyn C. Migliacci, Pablo H. Montero, Daniella Karassawa Zanoni, Jatin P. Shah, Snehal G. Patel, Ian Ganly Source Type: research
Straticyte demonstrates prognostic value over oral epithelial dysplasia grade for oral potentially malignant lesion assessment
Available online (Source: Oral Oncology)
Source: Oral Oncology - January 22, 2018 Category: Cancer & Oncology Authors: Jason T.K. Hwang, Ying R. Gu, Benjamin J. Dickson, Mi Shen, Ranju Ralhan, Paul G. Walfish, David Mock, Kenneth P.H. Pritzker Source Type: research
Editorial Board/Aims & Scope
(Source: Oral Oncology)
Source: Oral Oncology - January 22, 2018 Category: Cancer & Oncology Source Type: research
Effect of adjuvant radiotherapy treatment center volume on overall survival
The association between healthcare outcomes and institution and physician volume is ubiquitous in the medical literature regardless of case volume definitions and outcomes assessed [1,2]. There is a documented positive association between institution volume and healthcare outcomes as well as physician volume and healthcare outcomes for a wide range of procedures and conditions [3]. It has been postulated that increased experience and practice may account for this association. However, others have argued that improved outcomes, particularly with publicly reported results, may attract a larger volume of patients due to incre...
Source: Oral Oncology - January 19, 2018 Category: Cancer & Oncology Authors: Ramez Philips, Daniel Martin, Antoine Eskander, Jeffrey Schord, Nicole Brown, Songzhu Zhao, Guy Brock, Bhavna Kumar, Ricardo Carrau, Enver Ozer, Amit Agrawal, Stephen Y. Kang, James W. Rocco, David Schuller, Syed Ali, Dukagjin Blakaj, Aashish Bhatt, John Source Type: research
