Prognostic significance and optimal candidates of primary tumor resection in major salivary gland carcinoma patients with distant metastases at initial presentation: A population-based study

Major salivary gland carcinoma (MaSGC) constitutes less than 5% of all head and neck malignancies but consists of more than 20 histologic types with heterogeneous clinical presentation, biological behavior and prognosis according to the WHO classification updated in 2005 [1,2]. Distant metastasis, although relatively uncommon, is regarded as one of the most frequent failures and a significant concern in the management of MaSGC [3]. In the up-to-date NCCN guideline, chemotherapy, expectant management, selected metastasectomy and best supportive care remain the only management approaches for patients with metastatic MaSGC at initial presentation [4].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research