The Prevalence of Osteopenia and Osteoporosis Among Malaysian Type 2 Diabetic Patients Using Quantitative Ultrasound Densitometer.
Conclusion: The study findings revealed that the assessment of T2DM patients' bone health and related factor are essential and future educational programs are crucial to improve osteoporosis management.
PMID: 29755605 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - May 16, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications.
Conclusion: The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation and gene repression; however, there are some exceptions to this rule. Recently, the development of genome-wide methylation and genome-wide hydroxymethylation profiles has demonstrated that several genes previously associated with OA can have changes in their methylation status, favoring the development of the disease, and these have even shown the role of other epigenetic markers.
PMID: 29682093 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - April 25, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis.
Conclusion: Stimulation with mycobacterial synthetic analogue led to higher secretion of IL-6 and higher expression of MINCLE in PBMCs of patients with TA as compared to healthy controls.
PMID: 29643949 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - April 13, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women.
Conclusion: Our results suggest that vitamin K1 may contribute to maintain bone mineral density. Vitamin K1 may have a role in diagnosing post-menopausal osteoporosis. Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.
PMID: 29541269 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - March 17, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Role of Diet in Influencing Rheumatoid Arthritis Disease Activity.
Conclusion: Specifically more research is needed to explore the association of diet and the gut microbiome and how this can influence RA disease activity.
PMID: 29515679 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - March 10, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Interethnic Variations and Clinical Features of Spondyloarthropathies in a Middle Eastern Country.
Conclusion: This study on 141 patients is the largest to analyse inter-ethnic variations in SpA patients in the region. Our cohort shows a short delay in diagnosis with a relatively higher Anti-TNF usage.
PMID: 29456775 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - February 21, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Long-Term Outcomes in Puerto Ricans with Rheumatoid Arthritis (RA) Receiving Early Treatment with Disease-Modifying Anti-Rheumatic Drugs using the American College of Rheumatology Definition of Early RA.
Conclusion: Using the ACR definition of early RA, this group of patients treated with DMARDs within 6 months of disease had better long-term outcomes with less physical damage and functional impairment.
PMID: 29387286 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - February 2, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Dose Escalation and Co-therapy Intensification Between Etanercept, Adalimumab, and Infliximab: The CADURA Study.
Conclusion: Physicians were more likely to escalate the dose of IFX, but optimize co-therapy with ADA and ETN. ETN patients had no dose escalation and were less likely to have DMARD and/or glucocorticoid intensification than ADA patients. ETN-treated patients had lower costs compared to IFX patients.
PMID: 29296125 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - January 5, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Predictor of the Simplified Disease Activity Index 50 (SDAI 50) at Month 3 of bDMARD Treatment in Patients with Long-Established Rheumatoid Arthritis.
Conclusion: Our study demonstrated that RA patients with shorter disease duration, no smoking, and higher RA disease activity are more likely to achieve SDAI 50 through bDMARD treatment.
PMID: 29290847 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - January 3, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
SLE and Serum Complement: Causative, Concomitant or Coincidental?
Conclusion: Complement activation plays a key role in the pathophysiology of SLE and it is recommended to continue monitoring serum levels of C3 and C4 to assess for disease activity. However, it is important to note that decreased serum complement is not consistently associated with disease flares.It is clinically important to find novel ways to assess disease activity in SLE. Reduced serum levels of cell-bound complement activation products may more accurately reflect disease activity than conventional serum C3 and C4 monitoring.
PMID: 29290848 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - January 3, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Is Male Rheumatoid Arthritis an Occupational Disease? A Review.
CONCLUSION: We postulate that the inhalation of dust, metals and fumes is a significant trigger factor for RA development in male patients and that male RA should be considered an occupational disease. To the best of our knowledge, this is the first review of occupations as a risk factor for RA in relation to the potential underlying pathophysiology.
PMID: 28932330 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 23, 2017 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Predictive Value of Serum Infliximab Levels at Induction Phase in Rheumatoid Arthritis Patients.
CONCLUSIONS: In RA, ITL at induction phase are inversely associated with Infliximab clearance and clinical outcomes at W54. ATI was the main reason for low early ITL. A predictive value of ITL at W6 was found as a useful prognostic measure of treatment efficacy.
PMID: 28761564 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - August 2, 2017 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Axial Spondyloarthritis and Cigarette Smoking.
CONCLUSION: Our study suggests that there is a significant association between smoking and male sex and the severity of the disease.
PMID: 28659998 [PubMed - in process] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - June 30, 2017 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes.
CONCLUSION: PC may exert its OA disease modifying effect, in part, through a crystal-independent mechanism or by inhibiting the expressions of many genes implicated in OA disease process, and at the same time, stimulating the expression of genes implicated in chondroprotection and production of extracellular matrices.
PMID: 28659999 [PubMed - in process] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - June 30, 2017 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Hip Abductor Strengthening Improves Physical Function Following Total Knee Replacement: One-Year Follow-Up of a Randomized Pilot Study.
CONCLUSION: Hip abductor strengthening showed superior improvements in single leg stance test and six minute walk test. Hip abductor strengthening exercises has the potential to improve physical function following total knee replacement.
PMID: 28567148 [PubMed - in process] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - June 2, 2017 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
