Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis
Nature Genetics 49, 1120 (2017).
doi:10.1038/ng.3885
Authors: Kazuyoshi Ishigaki, Yuta Kochi, Akari Suzuki, Yumi Tsuchida, Haruka Tsuchiya, Shuji Sumitomo, Kensuke Yamaguchi, Yasuo Nagafuchi, Shinichiro Nakachi, Rika Kato, Keiichi Sakurai, Hirofumi Shoda, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Fuyuki Miya, Tatsuhiko Tsunoda, Yukinori Okada, Yukihide Momozawa, Yoichiro Kamatani, Ryo Yamada, Michiaki Kubo, Keishi Fujio & Kazuhiko Yamamoto
Recent evidence suggests that a substantial portion of complex disease risk alleles modify gene expression in a cell-specific manner. To identify candidate causal g...
Source: Nature Genetics - May 29, 2017 Category: Genetics & Stem Cells Authors: Kazuyoshi Ishigaki Yuta Kochi Akari Suzuki Yumi Tsuchida Haruka Tsuchiya Shuji Sumitomo Kensuke Yamaguchi Yasuo Nagafuchi Shinichiro Nakachi Rika Kato Keiichi Sakurai Hirofumi Shoda Katsunori Ikari Atsuo Taniguchi Hisashi Yamanaka Fuyuki Miya Tatsuhiko Ts Tags: Letter Source Type: research
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci
Nature Genetics 49, 993 (2017).
doi:10.1038/ng.3875
Authors: Tin Aung, Mineo Ozaki, Mei Chin Lee, Ursula Schlötzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P Igo, Aravind Haripriya, Susan E Williams, Yury S Astakhov, Andrew C Orr, Kathryn P Burdon, Satoko Nakano, Kazuhiko Mori, Khaled Abu-Amero, Michael Hauser, Zheng Li, Gopalakrishnan Prakadeeswari, Jessica N Cooke Bailey, Alina Popa Cherecheanu, Jae H Kang, Sarah Nelson, Ken Hayashi, Shin-ichi Manabe, Shigeyasu Kazama, Tomasz Zarnowski, Kenji Inoue, Murat Irkec, Miguel Coca-Prados, Kazuhisa Sugiyama, Irma Järvelä, Patricio Schlot...
Source: Nature Genetics - May 29, 2017 Category: Genetics & Stem Cells Authors: Tin Aung Mineo Ozaki Mei Chin Lee Ursula Schl ö tzer-Schrehardt Gudmar Thorleifsson Takanori Mizoguchi Robert P Igo Aravind Haripriya Susan E Williams Yury S Astakhov Andrew C Orr Kathryn P Burdon Satoko Nakano Kazuhiko Mori Khaled Abu-Amero Michael Haus Tags: Article Source Type: research
Corrigendum: A study of allelic diversity underlying flowering-time adaptation in maize landraces
Nature Genetics 49, 970 (2017).
doi:10.1038/ng0617-970c
Author: J Alberto Romero Navarro, Martha Wilcox, Juan Burgueño, Cinta Romay, Kelly Swarts, Samuel Trachsel, Ernesto Preciado, Arturo Terron, Humberto Vallejo Delgado, Victor Vidal, Alejandro Ortega, Armando Espinoza Banda, Noel Orlando Gómez Montiel, Ivan Ortiz-Monasterio, Félix San Vicente, Armando Guadarrama Espinoza, Gary Atlin, Peter Wenzl, Sarah Hearne & Edward S Buckler (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: J Alberto Romero Navarro Martha Wilcox Juan Burgue ñ o Cinta Romay Kelly Swarts Samuel Trachsel Ernesto Preciado Arturo Terron Humberto Vallejo Delgado Victor Vidal Alejandro Ortega Armando Espinoza Banda Noel Orlando G ó mez Montiel Ivan Ortiz-Monaster Tags: Corrigendum Source Type: research
Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ER α metastatic breast cancer
Nature Genetics 49, 970 (2017).
doi:10.1038/ng0617-970b
Author: Luca Magnani, Gianmaria Frigè, Raffaella Maria Gadaleta, Giacomo Corleone, Sonia Fabris, Mannus H Kempe, Pernette J Vershure, Iros Barozzi, Valentina Vircillo, Sung-Pil Hong, Ylenia Perone, Massimo Saini, Andreas Trumpp, Giuseppe Viale, Antonino Neri, Simak Ali, Marco Angelo Colleoni, Giancarlo Pruneri & Saverio Minucci (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Luca Magnani Gianmaria Frig è Raffaella Maria Gadaleta Giacomo Corleone Sonia Fabris Mannus H Kempe Pernette J Vershure Iros Barozzi Valentina Vircillo Sung-Pil Hong Ylenia Perone Massimo Saini Andreas Trumpp Giuseppe Viale Antonino Neri Simak Ali Marco Tags: Corrigendum Source Type: research
Corrigendum: Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells
Nature Genetics 49, 970 (2017).
doi:10.1038/ng0617-970a
Author: Jin Xu, Ava C Carter, Anne-Valerie Gendrel, Mikael Attia, Joshua Loftus, William J Greenleaf, Robert Tibshirani, Edith Heard & Howard Y Chang (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Jin Xu Ava C Carter Anne-Valerie Gendrel Mikael Attia Joshua Loftus William J Greenleaf Robert Tibshirani Edith Heard Howard Y Chang Tags: Corrigendum Source Type: research
Erratum: Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Nature Genetics 49, 970 (2017).
doi:10.1038/ng0617-970d
Author: Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse & Marc Lecuit (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Myl è ne M Maury Yu-Huan Tsai Caroline Charlier Marie Touchon Viviane Chenal-Francisque Alexandre Leclercq Alexis Criscuolo Charlotte Gaultier Sophie Roussel Anne Brisabois Olivier Disson Eduardo P C Rocha Sylvain Brisse Marc Lecuit Tags: Erratum Source Type: research
Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
Nature Genetics 49, 969 (2017).
doi:10.1038/ng0617-969c
Author: Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton...
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Natalie D Shaw Harrison Brand Zachary A Kupchinsky Hemant Bengani Lacey Plummer Takako I Jones Serkan Erdin Kathleen A Williamson Joe Rainger Alexei Stortchevoi Kaitlin Samocha Benjamin B Currall Donncha S Dunican Ryan L Collins Jason R Willer Angela Lek Tags: Corrigendum Source Type: research
Corrigendum: Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia
Nature Genetics 49, 969 (2017).
doi:10.1038/ng0617-969b
Authors: Esther Meyer, Keren J Carss, Julia Rankin, John M E Nichols, Detelina Grozeva, Agnel P Joseph, Niccolo E Mencacci, Apostolos Papandreou, Joanne Ng, Serena Barral, Adeline Ngoh, Hilla Ben-Pazi, Michel A Willemsen, David Arkadir, Angela Barnicoat, Hagai Bergman, Sanjay Bhate, Amber Boys, Niklas Darin, Nicola Foulds, Nicholas Gutowski, Alison Hills, Henry Houlden, Jane A Hurst, Zvi Israel, Margaret Kaminska, Patricia Limousin, Daniel Lumsden, Shane McKee, Shibalik Misra, Shekeeb S Mohammed, Vasiliki Nakou, Joost Nicolai, Magnus Nilsson, Hardev Pall, Kath...
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Esther Meyer Keren J Carss Julia Rankin John M E Nichols Detelina Grozeva Agnel P Joseph Niccolo E Mencacci Apostolos Papandreou Joanne Ng Serena Barral Adeline Ngoh Hilla Ben-Pazi Michel A Willemsen David Arkadir Angela Barnicoat Hagai Bergman Sanjay Bha Tags: Corrigendum Source Type: research
Corrigendum: NANS-mediated synthesis of sialic acid is required for brain and skeletal development
Nature Genetics 49, 969 (2017).
doi:10.1038/ng0617-969a
Author: Clara D M van Karnebeek, Luisa Bonafé, Xiao-Yan Wen, Maja Tarailo-Graovac, Sara Balzano, Beryl Royer-Bertrand, Angel Ashikov, Livia Garavelli, Isabella Mammi, Licia Turolla, Catherine Breen, Dian Donnai, Valerie Cormier, Delphine Heron, Gen Nishimura, Shinichi Uchikawa, Belinda Campos-Xavier, Antonio Rossi, Thierry Hennet, Koroboshka Brand-Arzamendi, Jacob Rozmus, Keith Harshman, Brian J Stevenson, Enrico Girardi, Giulio Superti-Furga, Tammie Dewan, Alissa Collingridge, Jessie Halparin, Colin J Ross, Margot I Van Allen, Andrea Rossi, Udo F Engelke...
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Clara D M van Karnebeek Luisa Bonaf é Xiao-Yan Wen Maja Tarailo-Graovac Sara Balzano Beryl Royer-Bertrand Angel Ashikov Livia Garavelli Isabella Mammi Licia Turolla Catherine Breen Dian Donnai Valerie Cormier Delphine Heron Gen Nishimura Shinichi Uchikaw Tags: Corrigendum Source Type: research
Adenine N6-methylation in diverse fungi
Nature Genetics 49, 823 (2017).
doi:10.1038/ng.3873
Author: Michael F Seidl
A DNA modification—methylation of cytosines and adenines—has important roles in diverse processes such as regulation of gene expression and genome stability, yet until recently adenine methylation had been considered to be only a hallmark of prokaryotes. A new study identifies abundant adenine methylation of transcriptionally active genes in early-diverging fungi that, together with recent other work, emphasizes the importance of adenine methylation in eukaryotes. (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Michael F Seidl Tags: News and Views Source Type: research
Of giraffes' necks and the inheritance of chromatin states
Nature Genetics 49, 821 (2017).
doi:10.1038/ng.3881
Author: Vincenzo Pirrotta
New work reports that both derepressed and hyper-repressed chromatin states in animals can be transmitted to progeny for many generations. Transmission depends on genomic architecture and histone modifications. (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Vincenzo Pirrotta Tags: News and Views Source Type: research
Starting embryonic transcription for the first time
Nature Genetics 49, 820 (2017).
doi:10.1038/ng.3880
Authors: Ane Iturbide & Maria-Elena Torres-Padilla
Three studies highlight DUX proteins as key transcription factors regulating embryonic genome activation in early mammalian development. (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Ane Iturbide Maria-Elena Torres-Padilla Tags: News and Views Source Type: research
Finding useful data across multiple biomedical data repositories using DataMed
Nature Genetics 49, 816 (2017).
doi:10.1038/ng.3864
Authors: Lucila Ohno-Machado, Susanna-Assunta Sansone, George Alter, Ian Fore, Jeffrey Grethe, Hua Xu, Alejandra Gonzalez-Beltran, Philippe Rocca-Serra, Anupama E Gururaj, Elizabeth Bell, Ergin Soysal, Nansu Zong & Hyeon-eui Kim (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Lucila Ohno-Machado Susanna-Assunta Sansone George Alter Ian Fore Jeffrey Grethe Hua Xu Alejandra Gonzalez-Beltran Philippe Rocca-Serra Anupama E Gururaj Elizabeth Bell Ergin Soysal Nansu Zong Hyeon-eui Kim Tags: Commentary Source Type: research
Remembrance of epigenomes past
Nature Genetics 49, 815 (2017).
doi:10.1038/ng.3890
Understanding of how epigenetic information is acquired, processed and transmitted through cell division, and potentially across generations, remains limited. Mechanistic studies aiming to elucidate the molecular underpinnings of these phenomena may provide insights into development, disease susceptibility and evolution. (Source: Nature Genetics)
Source: Nature Genetics - May 26, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
The complex genetics of hypoplastic left heart syndrome
Nature Genetics 49, 1152 (2017).
doi:10.1038/ng.3870
Authors: Xiaoqin Liu, Hisato Yagi, Shazina Saeed, Abha S Bais, George C Gabriel, Zhaohan Chen, Kevin A Peterson, You Li, Molly C Schwartz, William T Reynolds, Manush Saydmohammed, Brian Gibbs, Yijen Wu, William Devine, Bishwanath Chatterjee, Nikolai T Klena, Dennis Kostka, Karen L de Mesy Bentley, Madhavi K Ganapathiraju, Phillip Dexheimer, Linda Leatherbury, Omar Khalifa, Anchit Bhagat, Maliha Zahid, William Pu, Simon Watkins, Paul Grossfeld, Stephen A Murray, George A Porter, Michael Tsang, Lisa J Martin, D Woodrow Benson, Bruce J Aronow & Cecilia W Lo
Cong...
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Xiaoqin Liu Hisato Yagi Shazina Saeed Abha S Bais George C Gabriel Zhaohan Chen Kevin A Peterson You Li Molly C Schwartz William T Reynolds Manush Saydmohammed Brian Gibbs Yijen Wu William Devine Bishwanath Chatterjee Nikolai T Klena Dennis Kostka Karen L Tags: Letter Source Type: research
