The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression
Nature Genetics 49, 895 (2017).
doi:10.1038/ng.3852
Authors: Paul L Babb, Nicholas F Lahens, Sandra M Correa-Garhwal, David N Nicholson, Eun Ji Kim, John B Hogenesch, Matjaž Kuntner, Linden Higgins, Cheryl Y Hayashi, Ingi Agnarsson & Benjamin F Voight (Source: Nature Genetics)
Source: Nature Genetics - May 1, 2017 Category: Genetics & Stem Cells Authors: Paul L Babb Nicholas F Lahens Sandra M Correa-Garhwal David N Nicholson Eun Ji Kim John B Hogenesch Matja ž Kuntner Linden Higgins Cheryl Y Hayashi Ingi Agnarsson Benjamin F Voight Tags: Article Source Type: research
DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora
Nature Genetics 49, 887 (2017).
doi:10.1038/ng.3857
Authors: Eugene Gladyshev & Nancy Kleckner (Source: Nature Genetics)
Source: Nature Genetics - May 1, 2017 Category: Genetics & Stem Cells Authors: Eugene Gladyshev Nancy Kleckner Tags: Article Source Type: research
Innate and adaptive immunity shape circulating HCV strains
Nature Genetics 49, 657 (2017).
doi:10.1038/ng.3856
Authors: Silvana Gaudieri & Michaela Lucas
An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: Silvana Gaudieri Michaela Lucas Tags: News and Views Source Type: research
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
Nature Genetics 49, 655 (2017).
doi:10.1038/ng.3853
Authors: Brittany C Michel & Cigall Kadoch
Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood. Newly identified loss-of-function mutations in the SMARCD2 gene (part of the SMARCD1, SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role specifically for the SMARCD2 subunit in granulopoiesis, and further investigation imp...
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: Brittany C Michel Cigall Kadoch Tags: News and Views Source Type: research
Becoming weeds
Nature Genetics 49, 654 (2017).
doi:10.1038/ng.3851
Author: C Neal Stewart
A new resequencing analysis of weedy rice (Oryza sativa L.) biotypes illuminates distinct evolutionary paths and outcomes of de-domestication and ferality. This largest effort to date in weedy plant genomics gives a better understanding of weediness while also providing a promising source of alleles for rice breeding. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: C Neal Stewart Tags: News and Views Source Type: research
The future of human genome editing
Nature Genetics 49, 653 (2017).
doi:10.1038/ng.3860
With the advent of precision genome editing, the ability to modify living organisms has proceeded with remarkable speed and breadth. Any application of this technology to the human germ line must be tightly coupled to deliberate consideration of the consequences, both scientific and social, of introducing heritable alterations to the human population. We recommend constant oversight and evaluation of human germline genome editing to balance prudence with discovery, and risk with progress. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Innate and adaptive immunity shape circulating HCV strains
Nature Genetics 49, 657 (2017).
doi:10.1038/ng.3856
Authors: Silvana Gaudieri & Michaela Lucas
An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: Silvana Gaudieri Michaela Lucas Tags: News and Views Source Type: research
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
Nature Genetics 49, 655 (2017).
doi:10.1038/ng.3853
Authors: Brittany C Michel & Cigall Kadoch
Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood. Newly identified loss-of-function mutations in the SMARCD2 gene (part of the SMARCD1, SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role specifically for the SMARCD2 subunit in granulopoiesis, and further investigation imp...
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: Brittany C Michel Cigall Kadoch Tags: News and Views Source Type: research
Becoming weeds
Nature Genetics 49, 654 (2017).
doi:10.1038/ng.3851
Author: C Neal Stewart
A new resequencing analysis of weedy rice (Oryza sativa L.) biotypes illuminates distinct evolutionary paths and outcomes of de-domestication and ferality. This largest effort to date in weedy plant genomics gives a better understanding of weediness while also providing a promising source of alleles for rice breeding. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Authors: C Neal Stewart Tags: News and Views Source Type: research
The future of human genome editing
Nature Genetics 49, 653 (2017).
doi:10.1038/ng.3860
With the advent of precision genome editing, the ability to modify living organisms has proceeded with remarkable speed and breadth. Any application of this technology to the human germ line must be tightly coupled to deliberate consideration of the consequences, both scientific and social, of introducing heritable alterations to the human population. We recommend constant oversight and evaluation of human germline genome editing to balance prudence with discovery, and risk with progress. (Source: Nature Genetics)
Source: Nature Genetics - April 26, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila
Nature Genetics 49, 876 (2017).
doi:10.1038/ng.3848
Authors: Filippo Ciabrelli, Federico Comoglio, Simon Fellous, Boyan Bonev, Maria Ninova, Quentin Szabo, Anne Xuéreb, Christophe Klopp, Alexei Aravin, Renato Paro, Frédéric Bantignies & Giacomo Cavalli (Source: Nature Genetics)
Source: Nature Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Filippo Ciabrelli Federico Comoglio Simon Fellous Boyan Bonev Maria Ninova Quentin Szabo Anne Xu é reb Christophe Klopp Alexei Aravin Renato Paro Fr é d é ric Bantignies Giacomo Cavalli Tags: Article Source Type: research
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells
Nature Genetics 49, 866 (2017).
doi:10.1038/ng.3854
Authors: Ly P Vu, Camila Prieto, Elianna M Amin, Sagar Chhangawala, Andrei Krivtsov, M Nieves Calvo-Vidal, Timothy Chou, Arthur Chow, Gerard Minuesa, Sun Mi Park, Trevor S Barlowe, James Taggart, Patrick Tivnan, Raquel P Deering, Lisa P Chu, Jeong-Ah Kwon, Cem Meydan, Javier Perales-Paton, Arora Arshi, Mithat Gönen, Christopher Famulare, Minal Patel, Elisabeth Paietta, Martin S Tallman, Yuheng Lu, Jacob Glass, Francine E Garret-Bakelman, Ari Melnick, Ross Levine, Fatima Al-Shahrour, Marcus Järås, Nir Hacohen, Alexia Hwang, Ralph Garippa, Christopher...
Source: Nature Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Ly P Vu Camila Prieto Elianna M Amin Sagar Chhangawala Andrei Krivtsov M Nieves Calvo-Vidal Timothy Chou Arthur Chow Gerard Minuesa Sun Mi Park Trevor S Barlowe James Taggart Patrick Tivnan Raquel P Deering Lisa P Chu Jeong-Ah Kwon Cem Meydan Javier Peral Tags: Article Source Type: research
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes
Nature Genetics 49, 856 (2017).
doi:10.1038/ng.3849
Authors: Yi Kan Wang, Ali Bashashati, Michael S Anglesio, Dawn R Cochrane, Diljot S Grewal, Gavin Ha, Andrew McPherson, Hugo M Horlings, Janine Senz, Leah M Prentice, Anthony N Karnezis, Daniel Lai, Mohamed R Aniba, Allen W Zhang, Karey Shumansky, Celia Siu, Adrian Wan, Melissa K McConechy, Hector Li-Chang, Alicia Tone, Diane Provencher, Manon de Ladurantaye, Hubert Fleury, Aikou Okamoto, Satoshi Yanagida, Nozomu Yanaihara, Misato Saito, Andrew J Mungall, Richard Moore, Marco A Marra, C Blake Gilks, Anne-Marie Mes-Masson, Jessica N McAlpine, Samuel Aparicio, David...
Source: Nature Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Yi Kan Wang Ali Bashashati Michael S Anglesio Dawn R Cochrane Diljot S Grewal Gavin Ha Andrew McPherson Hugo M Horlings Janine Senz Leah M Prentice Anthony N Karnezis Daniel Lai Mohamed R Aniba Allen W Zhang Karey Shumansky Celia Siu Adrian Wan Melissa K Tags: Article Source Type: research
Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci
Nature Genetics 49, 842 (2017).
doi:10.1038/ng.3855
Authors: Stefan Stender, Julia Kozlitina, Børge G Nordestgaard, Anne Tybjærg-Hansen, Helen H Hobbs & Jonathan C Cohen (Source: Nature Genetics)
Source: Nature Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Stefan Stender Julia Kozlitina B ø rge G Nordestgaard Anne Tybj æ rg-Hansen Helen H Hobbs Jonathan C Cohen Tags: Article Source Type: research
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
Nature Genetics 49, 834 (2017).
doi:10.1038/ng.3841
Authors: Felix R Day, Deborah J Thompson, Hannes Helgason, Daniel I Chasman, Hilary Finucane, Patrick Sulem, Katherine S Ruth, Sean Whalen, Abhishek K Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L Lunetta, Massimo Mangino, Brumat Marco, George McMahon, Sarah E Medland, Ilja M Nolte, Raymond Noordam, Teresa Nutile, Lavinia Paternoster, Natalia Perjakova, Eleonora Porcu, Lynda M Rose, Katharina...
Source: Nature Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Felix R Day Deborah J Thompson Hannes Helgason Daniel I Chasman Hilary Finucane Patrick Sulem Katherine S Ruth Sean Whalen Abhishek K Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina M Barbieri Thibaud Boutin Archie Campbell Ellen Demerath Ay Tags: Article Source Type: research
