Synchronized DNA cycling across a bacterial population
Nature Genetics 49, 1282 (2017).
doi:10.1038/ng.3915
Authors: Leo Baumgart, William Mather & Jeff Hasty
A defining goal of synthetic biology is to engineer cells to coordinate tasks that often require precise temporal modulation of gene expression. Although a variety of relatively small gene circuits have been constructed and characterized, their logical combination into larger networks remains a central challenge. This is due primarily to the lack of compatible and orthogonal elements for predictable dynamic control of gene expression. As an alternative approach to promoter-level regulation, we explored the us...
Source: Nature Genetics - July 10, 2017 Category: Genetics & Stem Cells Authors: Leo Baumgart William Mather Jeff Hasty Tags: Letter Source Type: research
Genotype – covariate interaction effects and the heritability of adult body mass index
Nature Genetics 49, 1174 (2017).
doi:10.1038/ng.3912
Authors: Matthew R Robinson, Geoffrey English, Gerhard Moser, Luke R Lloyd-Jones, Marcus A Triplett, Zhihong Zhu, Ilja M Nolte, Jana V van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, Patrik K E Magnusson, Nancy L Pedersen, Erik Ingelsson, Magnus Johannesson, Jian Yang, David Cesarini & Peter M Visscher (Source: Nature Genetics)
Source: Nature Genetics - July 10, 2017 Category: Genetics & Stem Cells Authors: Matthew R Robinson Geoffrey English Gerhard Moser Luke R Lloyd-Jones Marcus A Triplett Zhihong Zhu Ilja M Nolte Jana V van Vliet-Ostaptchouk Harold Snieder Tonu Esko Lili Milani Reedik M ä gi Andres Metspalu Patrik K E Magnusson Nancy L Pedersen Erik Ing Tags: Analysis Source Type: research
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Nature Genetics 49, 1274 (2017).
doi:10.1038/ng.3900
Authors: Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsush...
Source: Nature Genetics - July 3, 2017 Category: Genetics & Stem Cells Authors: Masafumi Seki Shunsuke Kimura Tomoya Isobe Kenichi Yoshida Hiroo Ueno Yaeko Nakajima-Takagi Changshan Wang Lin Lin Ayana Kon Hiromichi Suzuki Yusuke Shiozawa Keisuke Kataoka Yoichi Fujii Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Teppei Shimamura Kyoko Tags: Letter Source Type: research
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Nature Genetics 49, 1239 (2017).
doi:10.1038/ng.3906
Authors: Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S Kassim, Behnam Javidfar, Brigham J Hartley, Lisa Kleofas, Royce B Park, Benoit Labonte, Seok-Man Ho, Sandhya Chandrasekaran, Catherine Do, Brianna R Ramirez, Cyril J Peter, Julia T C W, Brian M Safaie, Hirofumi Morishita, Panos Roussos, Eric J Nestler, Anne Schaefer, Benjamin Tycko, Kristen J Brennand, Takeshi Yagi, Li Shen & Schahram Akbarian (Source: Nature Genetics)
Source: Nature Genetics - July 3, 2017 Category: Genetics & Stem Cells Authors: Yan Jiang Yong-Hwee Eddie Loh Prashanth Rajarajan Teruyoshi Hirayama Will Liao Bibi S Kassim Behnam Javidfar Brigham J Hartley Lisa Kleofas Royce B Park Benoit Labonte Seok-Man Ho Sandhya Chandrasekaran Catherine Do Brianna R Ramirez Cyril J Peter Julia T Tags: Article Source Type: research
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Nature Genetics 49, 1211 (2017).
doi:10.1038/ng.3909
Authors: Yu Liu, John Easton, Ying Shao, Jamie Maciaszek, Zhaoming Wang, Mark R Wilkinson, Kelly McCastlain, Michael Edmonson, Stanley B Pounds, Lei Shi, Xin Zhou, Xiaotu Ma, Edgar Sioson, Yongjin Li, Michael Rusch, Pankaj Gupta, Deqing Pei, Cheng Cheng, Malcolm A Smith, Jaime Guidry Auvil, Daniela S Gerhard, Mary V Relling, Naomi J Winick, Andrew J Carroll, Nyla A Heerema, Elizabeth Raetz, Meenakshi Devidas, Cheryl L Willman, Richard C Harvey, William L Carroll, Kimberly P Dunsmore, Stuart S Winter, Brent L Wood, Brian P Sorrentino, James R Downing, Mignon L Loh...
Source: Nature Genetics - July 3, 2017 Category: Genetics & Stem Cells Authors: Yu Liu John Easton Ying Shao Jamie Maciaszek Zhaoming Wang Mark R Wilkinson Kelly McCastlain Michael Edmonson Stanley B Pounds Lei Shi Xin Zhou Xiaotu Ma Edgar Sioson Yongjin Li Michael Rusch Pankaj Gupta Deqing Pei Cheng Cheng Malcolm A Smith Jaime Guidr Tags: Article Source Type: research
Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Nature Genetics 49, 1202 (2017).
doi:10.1038/ng.3911
Authors: Terence D Capellini, Hao Chen, Jiaxue Cao, Andrew C Doxey, Ata M Kiapour, Michael Schoor & David M Kingsley (Source: Nature Genetics)
Source: Nature Genetics - July 3, 2017 Category: Genetics & Stem Cells Authors: Terence D Capellini Hao Chen Jiaxue Cao Andrew C Doxey Ata M Kiapour Michael Schoor David M Kingsley Tags: Article Source Type: research
Transposase-driven rearrangements in human tumors
Nature Genetics 49, 975 (2017).
doi:10.1038/ng.3908
Authors: Stephen C Mack, Hiromichi Suzuki & Michael D Taylor
A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification. (Source: Nature Genetics)
Source: Nature Genetics - June 28, 2017 Category: Genetics & Stem Cells Authors: Stephen C Mack Hiromichi Suzuki Michael D Taylor Tags: News and Views Source Type: research
Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses
Nature Genetics 49, 974 (2017).
doi:10.1038/ng.3902
Authors: Dixie L Mager & Matthew C Lorincz
A study in this issue demonstrates that epigenome-modifying drugs used in cancer chemotherapy induce transcription from thousands of previously unannotated transcription start sites, most of which are derived from ancient endogenous retroviruses (ERVs). This work, coupled with previous related findings, suggests that induction of ERVs, rather than direct effects on specific genes, may have a central role in the cellular responses to such agents and, in turn, their therapeutic efficacy. (Source: Nature Genetics)
Source: Nature Genetics - June 28, 2017 Category: Genetics & Stem Cells Authors: Dixie L Mager Matthew C Lorincz Tags: News and Views Source Type: research
Promoting transcription over long distances
Nature Genetics 49, 972 (2017).
doi:10.1038/ng.3904
Authors: Rui R Catarino, Christoph Neumayr & Alexander Stark
Promoters and enhancers have long been regarded as distinct elements, a notion that has been challenged more recently. Two new studies now identify promoters that function as long-range enhancers in vivo to regulate the transcription of distal genes. (Source: Nature Genetics)
Source: Nature Genetics - June 28, 2017 Category: Genetics & Stem Cells Authors: Rui R Catarino Christoph Neumayr Alexander Stark Tags: News and Views Source Type: research
Data models to GO-FAIR
Nature Genetics 49, 971 (2017).
doi:10.1038/ng.3910
This journal and Scientific Data are calling for submissions containing linked open data models that embody and extend the FAIR principles: that data should be findable, accessible, interoperable and reusable by both humans and machines. These principles are achievable with existing resources, languages and vocabularies to enable computers to combine and reanalyze data sets automatically and lead humans to new discoveries. (Source: Nature Genetics)
Source: Nature Genetics - June 28, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Neuroblastoma is composed of two super-enhancer-associated differentiation states
Nature Genetics 49, 1261 (2017).
doi:10.1038/ng.3899
Authors: Tim van Groningen, Jan Koster, Linda J Valentijn, Danny A Zwijnenburg, Nurdan Akogul, Nancy E Hasselt, Marloes Broekmans, Franciska Haneveld, Natalia E Nowakowska, Johannes Bras, Carel J M van Noesel, Aldo Jongejan, Antoine H van Kampen, Linda Koster, Frank Baas, Lianne van Dijk-Kerkhoven, Margriet Huizer-Smit, Maria C Lecca, Alvin Chan, Arjan Lakeman, Piet Molenaar, Richard Volckmann, Ellen M Westerhout, Mohamed Hamdi, Peter G van Sluis, Marli E Ebus, Jan J Molenaar, Godelieve A Tytgat, Bart A Westerman, Johan van Nes & Rogier Versteeg
Neuroblastoma...
Source: Nature Genetics - June 26, 2017 Category: Genetics & Stem Cells Authors: Tim van Groningen Jan Koster Linda J Valentijn Danny A Zwijnenburg Nurdan Akogul Nancy E Hasselt Marloes Broekmans Franciska Haneveld Natalia E Nowakowska Johannes Bras Carel J M van Noesel Aldo Jongejan Antoine H van Kampen Linda Koster Frank Baas Lianne Tags: Letter Source Type: research
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
Nature Genetics 49, 1231 (2017).
doi:10.1038/ng.3901
Authors: Terrence F Meehan, Nathalie Conte, David B West, Julius O Jacobsen, Jeremy Mason, Jonathan Warren, Chao-Kung Chen, Ilinca Tudose, Mike Relac, Peter Matthews, Natasha Karp, Luis Santos, Tanja Fiegel, Natalie Ring, Henrik Westerberg, Simon Greenaway, Duncan Sneddon, Hugh Morgan, Gemma F Codner, Michelle E Stewart, James Brown, Neil Horner, Melissa Haendel, Nicole Washington, Christopher J Mungall, Corey L Reynolds, Juan Gallegos, Valerie Gailus-Durner, Tania Sorg, Guillaume Pavlovic, Lynette R Bower, Mark Moore, Iva Morse, Xiang Gao, Glauco P Tocchini-Vale...
Source: Nature Genetics - June 26, 2017 Category: Genetics & Stem Cells Authors: Terrence F Meehan Nathalie Conte David B West Julius O Jacobsen Jeremy Mason Jonathan Warren Chao-Kung Chen Ilinca Tudose Mike Relac Peter Matthews Natasha Karp Luis Santos Tanja Fiegel Natalie Ring Henrik Westerberg Simon Greenaway Duncan Sneddon Hugh Mo Tags: Article Source Type: research
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
Nature Genetics 49, 1219 (2017).
doi:10.1038/ng.3905
Authors: Sjors M Kas, Julian R de Ruiter, Koen Schipper, Stefano Annunziato, Eva Schut, Sjoerd Klarenbeek, Anne Paulien Drenth, Eline van der Burg, Christiaan Klijn, Jelle J ten Hoeve, David J Adams, Marco J Koudijs, Jelle Wesseling, Micha Nethe, Lodewyk F A Wessels & Jos Jonkers (Source: Nature Genetics)
Source: Nature Genetics - June 26, 2017 Category: Genetics & Stem Cells Authors: Sjors M Kas Julian R de Ruiter Koen Schipper Stefano Annunziato Eva Schut Sjoerd Klarenbeek Anne Paulien Drenth Eline van der Burg Christiaan Klijn Jelle J ten Hoeve David J Adams Marco J Koudijs Jelle Wesseling Micha Nethe Lodewyk F A Wessels Jos Jonkers Tags: Article Source Type: research
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
Nature Genetics 49, 1167 (2017).
doi:10.1038/ng.3903
Authors: Tarjinder Singh, James T R Walters, Mandy Johnstone, David Curtis, Jaana Suvisaari, Minna Torniainen, Elliott Rees, Conrad Iyegbe, Douglas Blackwood, Andrew M McIntosh, Georg Kirov, Daniel Geschwind, Robin M Murray, Marta Di Forti, Elvira Bramon, Michael Gandal, Christina M Hultman, Pamela Sklar, Aarno Palotie, Patrick F Sullivan, Michael C O'Donovan, Michael J Owen & Jeffrey C Barrett (Source: Nature Genetics)
Source: Nature Genetics - June 26, 2017 Category: Genetics & Stem Cells Authors: Tarjinder Singh James T R Walters Mandy Johnstone David Curtis Jaana Suvisaari Minna Torniainen Elliott Rees Conrad Iyegbe Douglas Blackwood Andrew M McIntosh Georg Kirov Daniel Geschwind Robin M Murray Marta Di Forti Elvira Bramon Michael Gandal Christin Tags: Analysis Source Type: research
Identification of liver-specific enhancer – promoter activity in the 3 ′ untranslated region of the wild-type AAV2 genome
Nature Genetics 49, 1267 (2017).
doi:10.1038/ng.3893
Authors: Grant J Logan, Allison P Dane, Claus V Hallwirth, Christine M Smyth, Emilie E Wilkie, Anais K Amaya, Erhua Zhu, Neeta Khandekar, Samantha L Ginn, Sophia H Y Liao, Sharon C Cunningham, Natsuki Sasaki, Martí Cabanes-Creus, Patrick P L Tam, David W Russell, Leszek Lisowski & Ian E Alexander
Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications. The level of interest in this system has recently surged in response to reports of therapeutic efficacy in human clinical trials, most not...
Source: Nature Genetics - June 19, 2017 Category: Genetics & Stem Cells Authors: Grant J Logan Allison P Dane Claus V Hallwirth Christine M Smyth Emilie E Wilkie Anais K Amaya Erhua Zhu Neeta Khandekar Samantha L Ginn Sophia H Y Liao Sharon C Cunningham Natsuki Sasaki Mart í Cabanes-Creus Patrick P L Tam David W Russell Leszek Lisow Tags: Letter Source Type: research
