Transposase-driven rearrangements in human tumors

Nature Genetics 49, 975 (2017). doi:10.1038/ng.3908 Authors: Stephen C Mack, Hiromichi Suzuki & Michael D Taylor A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.
Source: Nature Genetics - Category: Genetics & Stem Cells Authors: Tags: News and Views Source Type: research