Patient-derived xenografts undergo mouse-specific tumor evolution
Nature Genetics 49, 1567 (2017).
doi:10.1038/ng.3967
Authors: Uri Ben-David, Gavin Ha, Yuen-Yi Tseng, Noah F Greenwald, Coyin Oh, Juliann Shih, James M McFarland, Bang Wong, Jesse S Boehm, Rameen Beroukhim & Todd R Golub (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Uri Ben-David Gavin Ha Yuen-Yi Tseng Noah F Greenwald Coyin Oh Juliann Shih James M McFarland Bang Wong Jesse S Boehm Rameen Beroukhim Todd R Golub Tags: Analysis Source Type: research
Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Nature Genetics 49, 1647 (2017).
doi:10.1038/ng.3965
Authors: Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao, Marc A Morgan, Clayton K Collings, Maria Gause, Yoh-hei Takahashi, Lu Wang, Emily J Rendleman, Stacy A Marshall, Annika Krueger, Elizabeth T Bartom, Andrea Piunti, Edwin R Smith, Nebiyu A Abshiru, Neil L Kelleher, Dale Dorsett & Ali Shilatifard
Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by KMT2C) and MLL4 (en...
Source: Nature Genetics - October 2, 2017 Category: Genetics & Stem Cells Authors: Ryan Rickels Hans-Martin Herz Christie C Sze Kaixiang Cao Marc A Morgan Clayton K Collings Maria Gause Yoh-hei Takahashi Lu Wang Emily J Rendleman Stacy A Marshall Annika Krueger Elizabeth T Bartom Andrea Piunti Edwin R Smith Nebiyu A Abshiru Neil L Kelle Tags: Letter Source Type: research
Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Nature Genetics 49, 1558 (2017).
doi:10.1038/ng1017-1558a
Authors: Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis ...
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Helen R Warren Evangelos Evangelou Claudia P Cabrera He Gao Meixia Ren Borbala Mifsud Ioanna Ntalla Praveen Surendran Chunyu Liu James P Cook Aldi T Kraja Fotios Drenos Marie Loh Niek Verweij Jonathan Marten Ibrahim Karaman Marcelo P Segura Lepe Paul F O' Tags: Corrigendum Source Type: research
Erratum: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Nature Genetics 49, 1558 (2017).
doi:10.1038/ng1017-1558d
Author: (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Tags: Erratum Source Type: research
Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Nature Genetics 49, 1558 (2017).
doi:10.1038/ng1017-1558c
Authors: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payton, Neil Pendleton, Robert Plomin, Cornelius A Rietveld, Henning Tiemeier, Cornelia M van Duijn & Danielle Posthuma (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Suzanne Sniekers Sven Stringer Kyoko Watanabe Philip R Jansen Jonathan R I Coleman Eva Krapohl Erdogan Taskesen Anke R Hammerschlag Aysu Okbay Delilah Zabaneh Najaf Amin Gerome Breen David Cesarini Christopher F Chabris William G Iacono M Arfan Ikram Magn Tags: Erratum Source Type: research
Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors
Nature Genetics 49, 1558 (2017).
doi:10.1038/ng1017-1558b
Authors: Anton G Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N Blackford, Christopher E Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D Socci, Elizabeth Perlman, Cristina R Antonescu, Charles W M Roberts, Hanno Steen, Elizabeth Mullen, Stephen P Jackson, David Torrents, Zhiping Weng, Scott A Armstrong & Alex Kentsis (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Anton G Henssen Richard Koche Jiali Zhuang Eileen Jiang Casie Reed Amy Eisenberg Eric Still Ian C MacArthur Elias Rodr í guez-Fos Santiago Gonzalez Montserrat Puiggr ò s Andrew N Blackford Christopher E Mason Elisa de Stanchina Mithat G ö nen Anne-Katr Tags: Erratum Source Type: research
Capturing condensin in chromosomes
This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Tatsuya Hirano Tags: News and Views Source Type: research
A fine LINE-1 in mouse embryonic chromatin regulation
Nature Genetics 49, 1418 (2017).
doi:10.1038/ng.3960
Author: Edward J Grow
The functional role of repetitive elements in mammalian genomes is still largely unexplored. A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are essential for normal embryonic development in mice. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Edward J Grow Tags: News and Views Source Type: research
Polycomb silencing mediated by specific DNA-binding recruiters
Nature Genetics 49, 1416 (2017).
doi:10.1038/ng.3961
Authors: Eduardo March & Sara Farrona
Regulation of epigenetic factors through their recruitment to specific genomic regions is still poorly understood. A recent study demonstrates a global mechanism of tethering Polycomb group (PcG) proteins through sequence-specific DNA-binding factors. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Authors: Eduardo March Sara Farrona Tags: News and Views Source Type: research
The multidimensional nucleus
Nature Genetics 49, 1415 (2017).
doi:10.1038/ng.3971
This issue highlights a range of genetic techniques and cell biological models required to begin to understand the levels of long-range regulation of gene expression as it occurs during cell differentiation. Explanations based on the specificity of covalent modifications and binding interactions intersect with evidence for conjectured mechanisms of topological loop creation and maintenance by transcription and motile protein activities. (Source: Nature Genetics)
Source: Nature Genetics - September 27, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Graphtyper enables population-scale genotyping using pangenome graphs
Nature Genetics 49, 1654 (2017).
doi:10.1038/ng.3964
Authors: Hannes P Eggertsson, Hakon Jonsson, Snaedis Kristmundsdottir, Eirikur Hjartarson, Birte Kehr, Gisli Masson, Florian Zink, Kristjan E Hjorleifsson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Ingileif Jonsdottir, Daniel F Gudbjartsson, Pall Melsted, Kari Stefansson & Bjarni V Halldorsson (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Hannes P Eggertsson Hakon Jonsson Snaedis Kristmundsdottir Eirikur Hjartarson Birte Kehr Gisli Masson Florian Zink Kristjan E Hjorleifsson Aslaug Jonasdottir Adalbjorg Jonasdottir Ingileif Jonsdottir Daniel F Gudbjartsson Pall Melsted Kari Stefansson Bjar Tags: Technical Report Source Type: research
Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma
Nature Genetics 49, 1624 (2017).
doi:10.1038/ng.3957
Authors: Phillips Y Huang, Eve Kandyba, Arnaud Jabouille, Jonas Sjolund, Atul Kumar, Kyle Halliwill, Melissa McCreery, Reyno DelRosario, Hio Chung Kang, Christine E Wong, Jost Seibler, Vincent Beuger, Maurizio Pellegrino, Adam Sciambi, Dennis J Eastburn & Allan Balmain (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Phillips Y Huang Eve Kandyba Arnaud Jabouille Jonas Sjolund Atul Kumar Kyle Halliwill Melissa McCreery Reyno DelRosario Hio Chung Kang Christine E Wong Jost Seibler Vincent Beuger Maurizio Pellegrino Adam Sciambi Dennis J Eastburn Allan Balmain Tags: Article Source Type: research
SMARCB1 is required for widespread BAF complex – mediated activation of enhancers and bivalent promoters
Nature Genetics 49, 1613 (2017).
doi:10.1038/ng.3958
Authors: Robert T Nakayama, John L Pulice, Alfredo M Valencia, Matthew J McBride, Zachary M McKenzie, Mark A Gillespie, Wai Lim Ku, Mingxiang Teng, Kairong Cui, Robert T Williams, Seth H Cassel, He Qing, Christian J Widmer, George D Demetri, Rafael A Irizarry, Keji Zhao, Jeffrey A Ranish & Cigall Kadoch (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Robert T Nakayama John L Pulice Alfredo M Valencia Matthew J McBride Zachary M McKenzie Mark A Gillespie Wai Lim Ku Mingxiang Teng Kairong Cui Robert T Williams Seth H Cassel He Qing Christian J Widmer George D Demetri Rafael A Irizarry Keji Zhao Jeffrey Tags: Article Source Type: research
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Nature Genetics 49, 1602 (2017).
doi:10.1038/ng.3963
Authors: Maxwell R Mumbach, Ansuman T Satpathy, Evan A Boyle, Chao Dai, Benjamin G Gowen, Seung Woo Cho, Michelle L Nguyen, Adam J Rubin, Jeffrey M Granja, Katelynn R Kazane, Yuning Wei, Trieu Nguyen, Peyton G Greenside, M Ryan Corces, Josh Tycko, Dimitre R Simeonov, Nabeela Suliman, Rui Li, Jin Xu, Ryan A Flynn, Anshul Kundaje, Paul A Khavari, Alexander Marson, Jacob E Corn, Thomas Quertermous, William J Greenleaf & Howard Y Chang (Source: Nature Genetics)
Source: Nature Genetics - September 25, 2017 Category: Genetics & Stem Cells Authors: Maxwell R Mumbach Ansuman T Satpathy Evan A Boyle Chao Dai Benjamin G Gowen Seung Woo Cho Michelle L Nguyen Adam J Rubin Jeffrey M Granja Katelynn R Kazane Yuning Wei Trieu Nguyen Peyton G Greenside M Ryan Corces Josh Tycko Dimitre R Simeonov Nabeela Suli Tags: Article Source Type: research
Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control
Nature Genetics 49, 1642 (2017).
doi:10.1038/ng.3956
Authors: Federico Tessadori, Jacques C Giltay, Jane A Hurst, Maarten P Massink, Karen Duran, Harmjan R Vos, Robert M van Es, Richard H Scott, Koen L I van Gassen, Jeroen Bakkers & Gijs van Haaften
Covalent modifications of histones have an established role as chromatin effectors, as they control processes such as DNA replication and transcription, and repair or regulate nucleosomal structure. Loss of modifications on histone N tails, whether due to mutations in genes belonging to histone-modifying complexes or mutations directly affecting the histone tails, c...
Source: Nature Genetics - September 18, 2017 Category: Genetics & Stem Cells Authors: Federico Tessadori Jacques C Giltay Jane A Hurst Maarten P Massink Karen Duran Harmjan R Vos Robert M van Es Richard H Scott Koen L I van Gassen Jeroen Bakkers Gijs van Haaften Tags: Letter Source Type: research
