Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor — Computational approach
Publication date: Available online 31 January 2019Source: Microvascular ResearchAuthor(s): Farshad M. Kashkooli, M. Soltani, M. Rezaeian, Erfan Taatizadeh, Mohammad-Hossein HamediAbstractThe solute transport distribution in a tumor is an important criterion in the evaluation of the cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the therapeutic effect and plays as a helpful tool to evaluate the chemotherapy treatment schedules. In the present study, an image-based spatio-temporal computational model of a solid tumor is provided for calculation of interstitial fluid flow and solute ...
Source: Microvascular Research - February 1, 2019 Category: Biochemistry Source Type: research
Inhaled carbon monoxide increases vasodilation in the microvascular circulation
Publication date: Available online 15 January 2019Source: Microvascular ResearchAuthor(s): Karalyn E. McRae, Jessica Pudwell, Nichole Peterson, Graeme N. SmithAbstractPreeclampsia (PE) is characterized by systemic maternal endothelial dysfunction. Changes in endothelial reactivity have been reported before the onset of clinical signs of PE, and continuing into the post-partum period. Women who smoke during pregnancy have a 33% reduced risk of developing PE. This reduced risk is hypothesized to be, in part, attributed to carbon monoxide (CO), a by-product of cigarette combustion and a known endogenous vasodilator. Determini...
Source: Microvascular Research - January 16, 2019 Category: Biochemistry Source Type: research
Effect of Varying Viscosity on Two-Fluid Model of Pulsatile Blood Flow through Porous Blood Vessels: A Comparative Study
Publication date: Available online 11 January 2019Source: Microvascular ResearchAuthor(s): Ashish Tiwari, Satyendra Singh ChauhanAbstractPresent work concerns the pulsatile blood flow of two-fluid model through porous blood vessels under the effect of radially varying viscosity. Blood is modeled as two-phase fluid model consisting a core region by non-Newtonian (Herschel-Bulkley) fluid and a plasma region modeled as Newtonian fluid. No slip condition has been used on wall and pressure gradient has been taken as periodic function of time. Up to first order approximate solutions of governing equations are obtained using pert...
Source: Microvascular Research - January 12, 2019 Category: Biochemistry Source Type: research
The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus
ConclusionsCoexisting autoimmune thyroiditis significantly deteriorates skin microcirculation function in pediatric non-complicated type 1 diabetic patients. This process is independent of patient age, diabetes duration and age of diabetes onset. (Source: Microvascular Research)
Source: Microvascular Research - January 4, 2019 Category: Biochemistry Source Type: research
Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
In this study, the middle cerebral artery occlusion and reperfusion surgery were conducted on rats, and mesenchymal stem cells were then engrafted into the injured cerebrovascular system. Our results showed that the host cells of injured cerebral microvasculature accepted the mitochondria transferred from the transplanted stem cells, thereby resulting in significantly improving in mitochondrial activity of injured microvasculature, enhancing angiogenesis, reducing infarct volume, and improving functional recovery. Our data provided the evidence that stem cells can rescue damaged cerebrovascular system in stroke through a m...
Source: Microvascular Research - January 4, 2019 Category: Biochemistry Source Type: research
