Microvascular responses during reactive hyperemia assessed by near-infrared spectroscopy and arterial stiffness in young, middle-aged, and older women
Publication date: Available online 28 December 2019Source: Microvascular ResearchAuthor(s): Masahiro Horiuchi, Koichi OkitaAbstractWe investigated the effects of age on microvascular responses during reactive hyperemia and arterial stiffness in 13 young (22 ± 1 years), 12 middle-aged (42 ± 5 years), and 15 older (63 ± 2 years) women. During the vascular occlusion test (VOT), forearm tissue oxygen saturation (StO2) was measured using near-infrared spectroscopy (NIRS). During reperfusion, the area under the curve (AUC) during hyperemia in young women (1123 ± 208% s) was significantly greater than ...
Source: Microvascular Research - December 28, 2019 Category: Biochemistry Source Type: research
Use of optical coherence tomography angiography for assessment of microvascular changes in the macula and optic nerve head in hypertensive patients without hypertensive retinopathy
ConclusionsSuperficial plexus VD, FAZ area, capillary density, and inner retinal thickness changed significantly in hypertensive patients without hypertensive retinopathy. However, only RNFL thickness was significantly thinner in patients who had>10 years of hypertension, compared to patients who had 5–10 years of hypertension. In addition, OCTA provided a method to prospectively assess changes in retinal microvasculature and thickness, thereby avoiding further long-term retinal damage in hypertensive patients. (Source: Microvascular Research)
Source: Microvascular Research - December 24, 2019 Category: Biochemistry Source Type: research
Long non-coding RNA NKILA inhibited angiogenesis of breast cancer through NF-κB/IL-6 signaling pathway
ConclusionOverexpression of NKILA could inhibit cell proliferation, migration and promote apoptosis of breast cancer cells. It could also inhibit cell proliferation, migration and angiogenesis of HUVEC through inhibiting IL-6 secretion via NF-κB signaling pathway. (Source: Microvascular Research)
Source: Microvascular Research - December 18, 2019 Category: Biochemistry Source Type: research
Is flow-mediated dilatation associated with near-infrared spectroscopy-derived magnitude of muscle O2 desaturation in healthy young and individuals at risk for cardiovascular disease?
In conclusion, FMD response did not correlate with the magnitude of muscle O2 desaturation, although it seems to be partially associated with O2 resaturation rate. (Source: Microvascular Research)
Source: Microvascular Research - December 14, 2019 Category: Biochemistry Source Type: research
Cardiovascular health and retinal microvascular geometry in Australian 11–12 year-olds
Publication date: May 2020Source: Microvascular Research, Volume 129Author(s): Mengjiao Liu, Kate Lycett, Melissa Wake, Mingguang He, Jessica A. Kerr, Richard Saffery, Markus Juonala, Tim Olds, Terry Dwyer, David P. Burgner, Tien Yin WongAbstractTraditional retinal microvascular parameters (smaller arteriolar and greater venular caliber) are associated with cardiovascular risk factors, pre-clinical vascular phenotypes and clinical cardiovascular events in adults. Although novel retinal microvascular geometric parameters showed analogous associations in adults, less is known whether these parameters are associated with card...
Source: Microvascular Research - December 14, 2019 Category: Biochemistry Source Type: research
Cardiovascular health and retinal microvascular geometry in Australian 11–12 year-olds
Publication date: Available online 10 December 2019Source: Microvascular ResearchAuthor(s): Mengjiao Liu, Kate Lycett, Melissa Wake, Mingguang He, Jessica A. Kerr, Richard Saffery, Markus Juonala, Tim Olds, Terry Dwyer, David P. Burgner, Tien Yin WongAbstractTraditional retinal microvascular parameters (smaller arteriolar and greater venular caliber) are associated with cardiovascular risk factors, pre-clinical vascular phenotypes and clinical cardiovascular events in adults. Although novel retinal microvascular geometric parameters showed analogous associations in adults, less is known whether these parameters are associa...
Source: Microvascular Research - December 11, 2019 Category: Biochemistry Source Type: research
Reply to comments by A. Pantokratoras on ““Electrokinetically modulated peristaltic transport of power-law fluids” by Prakash Goswami, Jeevanjyoti Chakraborty, Aditya Bandopadhyay, Suman Chakraborty, Microvascular Research 103 (2016) 41-54”, Microvascular Research (2019)
Publication date: May 2020Source: Microvascular Research, Volume 129Author(s): Prakash Goswami, Jeevanjyoti Chakraborty, Aditya Bandopadhyay, Suman Chakraborty (Source: Microvascular Research)
Source: Microvascular Research - December 7, 2019 Category: Biochemistry Source Type: research
Laser speckle contrast imaging, the future DBF imaging technique for TRP target engagement biomarker assays
ConclusionsThe LSCI technique was identified as the preferred method to capture capsaicin- and cinnamaldehyde-induced changes in DBF. Besides its reduced variability, the shorter scan time provides a major advantage, allowing real-time DBF measurements.Graphical abstract (Source: Microvascular Research)
Source: Microvascular Research - December 7, 2019 Category: Biochemistry Source Type: research
Reply to comments by A. Pantokratorason ““Electrokinetically modulated peristaltic transport of power-law fluids” by Prakash Goswami, Jeevanjyoti Chakraborty, Aditya Bandopadhyay, Suman Chakraborty, Microvascular Research 103 (2016) 41-54”, Microvascular Research (2019)
Publication date: Available online 30 November 2019Source: Microvascular ResearchAuthor(s): Prakash Goswami, Jeevanjyoti Chakraborty, Aditya Bandopadhyay, Suman Chakraborty (Source: Microvascular Research)
Source: Microvascular Research - December 1, 2019 Category: Biochemistry Source Type: research
Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers
ConclusionA single snack consisting on an acute oral load of carbohydrates induced a significant increase of endothelium-dependent microvascular vasodilation in healthy, young subjects. (Source: Microvascular Research)
Source: Microvascular Research - November 29, 2019 Category: Biochemistry Source Type: research
A pilot study of forearm microvascular impairment and pain while using a telephone
ConclusionThe phone conversation resulted in pain in many patients with suspected TOS. Transcutaneous oximetry can document the underlying ischemia. Forearm phone-call-induced pain may be indicative of TOS provided that no earplug or headset is used.Trial registration ClinicalTrials.gov NCT03355274 (Source: Microvascular Research)
Source: Microvascular Research - November 29, 2019 Category: Biochemistry Source Type: research
Corrigendum to “Transmural pressure drives proliferation of human arterial smooth muscle cells via mechanism associated with NADPH oxidase and Survivin” [Microvasc. Res. 126 (2019) 103905]
Publication date: Available online 19 November 2019Source: Microvascular ResearchAuthor(s): Kun Ran, Zhipeng Yang, Yu Zhao, Xuehu Wang (Source: Microvascular Research)
Source: Microvascular Research - November 20, 2019 Category: Biochemistry Source Type: research
Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay
In this study, DT loaded CS nanoparticles (CS-NPs) were produced by spray drying method for oral drug delivery. Structures of CS-NPs were elucidated by particle size, zeta potential, SEM, DSC, FT-IR and 1H NMR. High encapsulation efficiency was obtained (73–84%) for the prepared formulations. In vitro release was examined in pH 1.2 buffer and pH 6.8 buffer. DT-loaded CS-NPs showed prolonged release, particularly at pH 6.8. Weibull kinetic model was found to fit best to DT release from CS-NPs in both release medium. The anti-inflammatory activity of optimum formulation (M-DT) was examined using the in vivo HET-CAM a...
Source: Microvascular Research - November 20, 2019 Category: Biochemistry Source Type: research
Effects of hemodialysis on blood volume, macro- and microvascular function
ConclusionConventional HD resulting in substantial plasma volume removal do not alter large artery elastic properties, whereas intrinsic microvascular venular dilator function is markedly impaired, an effect directly associated with the increase in hemoconcentration. (Source: Microvascular Research)
Source: Microvascular Research - November 15, 2019 Category: Biochemistry Source Type: research
Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway
In conclusion, LLLT promotes the proliferation, migration, and angiogenesis of HUVECs via activation of the PI3K/Akt signaling pathway. (Source: Microvascular Research)
Source: Microvascular Research - November 15, 2019 Category: Biochemistry Source Type: research
