Corrigendum to “The radiosensitivity of endothelial cells isolated from human breast cancer and normal tissue in vitro” [Microvasc. Res. 84 (2012) 140-148]
Publication date: Available online 5 April 2019Source: Microvascular ResearchAuthor(s): Moon-Taek Park, Eun-Taex Oh, Min-Jeong Song, Woo-Jean Kim, Young Up Cho, Sei Joong Kim, Jee-Young Han, Jun-Kyu Suh, Eun Kyung Choi, Byung Uk Lim, Chang Won Song, Heon Joo Park (Source: Microvascular Research)
Source: Microvascular Research - April 6, 2019 Category: Biochemistry Source Type: research
Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes
Publication date: Available online 6 April 2019Source: Microvascular ResearchAuthor(s): Michele Sorelli, Piergiorgio Francia, Leonardo Bocchi, Alessandra De Bellis, Roberto AnichiniAbstractBackgroundThe burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest priorities of the clinical research in this field.ObjectiveTo assess the deterioration of physiological properties extracted from ...
Source: Microvascular Research - April 6, 2019 Category: Biochemistry Source Type: research
DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77
Publication date: Available online 28 March 2019Source: Microvascular ResearchAuthor(s): Jin Peng, Shengqiang Zhao, Yan Li, Gengming Niu, Chen Chen, Taiyang Ye, Dezheng Zhao, Huiyan ZengAbstractPathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth and skin wound healing via regulating the expression of the junctional proteins and integrins. However, the molecular mechanism, by which TR3/Nur77 regulates angiogenesis is not completely understood. Here, we were the first to find that TR3/Nur77, v...
Source: Microvascular Research - March 30, 2019 Category: Biochemistry Source Type: research
Comparison of transport of chemotherapeutic drugs in voxelized heterogeneous model of human brain tumor
In this study, a voxelized numerical model based on dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) and computational fluid dynamics (CFD) is employed to study the transport and efficacy of three different chemotherapeutic drugs, namely methotrexate, doxorubicin and cisplatin in human brain tumors. DCE-MRI data provides realistic heterogeneous vasculature of the tumor, the permeability of tissue to contrast agent, interstitial volume fraction (porosity) of the tissue and patient-specific arterial input function (AIF). The permeability of tissue to aforementioned drugs is determined by correlating it with the...
Source: Microvascular Research - March 28, 2019 Category: Biochemistry Source Type: research
Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
Publication date: Available online 15 March 2019Source: Microvascular ResearchAuthor(s): Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Ikuya Kimura, Atsushi Yamauchi, Yasufumi KataokaAbstractBlood–brain barrier (BBB) disruption is often mediated by neuroinflammation, and occurs during various neurodegenerative diseases including Parkinson's disease (PD). PD is characterized by loss of dopaminergic neurons and aggregated α-synuclein protein in inclusions known as Lewy bodies. Misfolded α-synuclein has been implicated in neurodegeneration and neuroinflammation through activation of microglia and astrocytes. Pericytes a...
Source: Microvascular Research - March 15, 2019 Category: Biochemistry Source Type: research
Microvascular abnormalities in asymptomatic chronic smokers: A videocapillaroscopic study
In conclusion, nailfold capillaroscopic abnormalities were more common among asymptomatic chronic smokers than healthy nonsmokers, with the enlargement of nailfold capillaries being the most common abnormality. Nailfold videocapillaroscopic examination may serve as an efficient tool in determining microvascular abnormalities in asymptomatic chronic smokers not only for risk stratification purposes, but also to take the measures needed to preclude future vascular events. (Source: Microvascular Research)
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research
The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites
ConclusionA concentration of 20 mmol/L MN generated the most reproducible microvascular response in the skin. The response varies between different body sites. (Source: Microvascular Research)
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research
Correlation between acute degradation of the endothelial glycocalyx and microcirculation dysfunction during cardiopulmonary bypass in cardiac surgery
ConclusionsGlycocalyx components are closely related to microcirculation perfusion disorders. Damage to the glycocalyx during surgery with CPB may play a key role in microcirculation perfusion dysfunction. (Source: Microvascular Research)
Source: Microvascular Research - March 11, 2019 Category: Biochemistry Source Type: research
miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling
In this study, we found that miR-205-5p was lowly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Restoration of miR-205-5p suppressed PASMCs proliferation. In contrast, molecule interacting with CasL 2 (MICAL2) was highly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Overexpression of MICAL2 promoted cell proliferation. Furthermore, miR-205-5p inhibited MICAL2 expression levels by targeting the MICAL2 3′ untranslated region. In addition, MICAL2 activated ERK1/2 signaling in PASMCs and ERK1/2 inhibitor blocked MICAL2-mediated-promotion effect on PASMCs proliferation. Th...
Source: Microvascular Research - March 8, 2019 Category: Biochemistry Source Type: research
Migration velocity of red blood cells in microchannels
Publication date: Available online 2 March 2019Source: Microvascular ResearchAuthor(s): Sylvain Losserand, Gwennou Coupier, Thomas PodgorskiAbstractThe lateral migration of red blood cells (RBCs) in confined channel flows is an important ingredient of microcirculatory hydrodynamics and is involved in the development of a cell free layer near vessel walls and influences the distribution of RBCs in networks. It is also relevant to a number of lab-on-chip applications. This migration is a consequence of their deformability and is due to the combined effects of hydrodynamic wall repulsion and the curvature of the fluid velocit...
Source: Microvascular Research - March 4, 2019 Category: Biochemistry Source Type: research
Microvascular reactivity in rehabilitating cardiac patients based on measurements of retinal blood vessel diameters
ConclusionsArteriolar and venular retinal microvascular responses in cardiac patients were different from the ones of healthy controls. Retinal microvascular response of cardiac patients improved during rehabilitation. (Source: Microvascular Research)
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research
Flow Mediated Skin Fluorescence technique reveals remarkable effect of age on microcirculation and metabolic regulation in type 1 diabetes
ConclusionFMSF appears to be an extremely useful technique for monitoring diabetic patients over time, enabling early diagnosis of potentially dysfunctional microcirculation and metabolic regulation. (Source: Microvascular Research)
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research
Editorial Board
Publication date: May 2019Source: Microvascular Research, Volume 123Author(s): (Source: Microvascular Research)
Source: Microvascular Research - February 16, 2019 Category: Biochemistry Source Type: research
Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers
Publication date: Available online 8 February 2019Source: Microvascular ResearchAuthor(s): Stephen C. Kanick, Peter A. Schneider, Bruce Klitzman, Natalie A. Wisniewski, Kerstin RebrinAbstractMeasurements of regional tissue oxygen serve as a proxy to monitor local perfusion and have the potential to guide therapeutic decisions in multiple clinical disciplines. Transcutaneous oximetry (tcpO2) is a commercially available noninvasive technique that uses an electrode to warm underlying skin tissue and measure the resulting oxygen tension at the skin surface. A novel approach is to directly measure interstitial tissue oxygen usi...
Source: Microvascular Research - February 9, 2019 Category: Biochemistry Source Type: research
Extended-wavelength diffuse reflectance spectroscopy for a comprehensive view of blood perfusion and tissue response in human forearm skin
ConclusionsEW-DRS appears to be a promising technique for monitoring perfusion, and could provide a useful tool in plastic and reconstructive surgery. The broad spectrum provides detailed information on the molecular changes taking place in the tissue. However, the technique must be thoroughly validated before it can be implemented in clinical practice. (Source: Microvascular Research)
Source: Microvascular Research - February 3, 2019 Category: Biochemistry Source Type: research
