Reproducible hindlimb ischemia model based on photochemically induced thrombosis to evaluate angiogenic effects
Publication date: Available online 18 August 2019Source: Microvascular ResearchAuthor(s): Sang-Soo Han, Zhen Jin, Byoung-Seok Lee, Ji-Seok Han, Jong-Jin Choi, Soon-Jung Park, Hyung-Min Chung, Anthony Safaa Mukhtar, Sung-Hwan Moon, Sun-Woong KangAbstractCritical limb ischemia is one of the most common types of peripheral arterial disease. Preclinical development of ischemia therapeutics relies on the availability of a relevant and reproducible in vivo disease model. Thus, establishing appropriate animal disease models is essential for the development of new therapeutic strategies. Currently, the most commonly employed model...
Source: Microvascular Research - August 20, 2019 Category: Biochemistry Source Type: research
The effects of aging and cardiovascular risk factors on microvascular function assessed by near-infrared spectroscopy
In conclusion, this study demonstrated that even though the effects of aging per se on microvascular function should not be completely neglected, the CVD risk factors seem to be determinant on microvascular responsiveness impairment associated with aging. (Source: Microvascular Research)
Source: Microvascular Research - August 17, 2019 Category: Biochemistry Source Type: research
Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors
ConclusionMost nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients. (Source: Microvascular Research)
Source: Microvascular Research - August 10, 2019 Category: Biochemistry Source Type: research
Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk
ConclusionWe conclude that signs of abnormal vascular function are similarly present and detectable in various microvascular beds, despite existing differences in their anatomical and physiological properties. (Source: Microvascular Research)
Source: Microvascular Research - August 1, 2019 Category: Biochemistry Source Type: research
Dissociation between macro- and microvascular parameters in the early phase of hemorrhagic shock
Publication date: Available online 31 July 2019Source: Microvascular ResearchAuthor(s): Ronald Lima, Nivaldo Villela, Raquel Castiglione, Maria das Graças C. de Souza, Eliete BouskelaAbstractHemorrhagic shock (HS) therapy is based on macrohemodynamic improvement, but it is not clear if this therapy correlates directly with increases in tissue perfusion. Aiming to clarify this point, we compared norepinephrine (NE, a vasoconstrictor), sodium nitroprusside (NP, a vasodilator) and levosimendan (LEV, an inodilator) treatments on macro and microvascular parameters using the hamster dorsal skinfold chamber preparation. One hour...
Source: Microvascular Research - July 31, 2019 Category: Biochemistry Source Type: research
Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope
ConclusionsWe, for the first time, report the successful assessment and quantification of the conjunctival microcirculatory haemodynamics using a smartphone-based system. (Source: Microvascular Research)
Source: Microvascular Research - July 20, 2019 Category: Biochemistry Source Type: research
The acute influence of sucrose consumption with and without vitamin C co-ingestion on microvascular reactivity in healthy young adults
ConclusionThe consumption of a sugar load representative of commercially available SSB did not influence microvascular reactivity. The co-ingestion of Vitamin C also failed to influence microvascular reactivity, but did increase the rate of oxygen extraction. (Source: Microvascular Research)
Source: Microvascular Research - July 19, 2019 Category: Biochemistry Source Type: research
Editorial Board
Publication date: September 2019Source: Microvascular Research, Volume 125Author(s): (Source: Microvascular Research)
Source: Microvascular Research - July 13, 2019 Category: Biochemistry Source Type: research
Transmural pressure drives proliferation of human arterial smooth muscle cells via mechanism associated with NADPH oxidase and Survivin
In this study, we show that transmural pressure (TP) promotes the proliferation of human arterial smooth muscle cells (HASMCs) and its related mechanism. HASMCs were treated with different TPs (0,100,120,140,160,180 and 200 mmHg) in a custom-made pressure loading apparatus for 6 h. Results showed that proliferation of HASMCs was significantly promoted when the TP was over 160 mmHg compared with 0 mmHg (atmosphere pressure). In like manner, the expressions of NADPH oxidase 2(Nox2) and Survivin (SVV) and production of intracellular reactive oxygen species (ROS) were all elevated distinctly when TP exceeded 160 mmHg...
Source: Microvascular Research - July 8, 2019 Category: Biochemistry Source Type: research
Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis
ConclusionsSSc patients showed decreased oral vasculature compared to controls. SDF imaging has shown the ability to be a useful diagnostic tool in the assessment of SSc. (Source: Microvascular Research)
Source: Microvascular Research - July 6, 2019 Category: Biochemistry Source Type: research
Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice
In this study, we investigated whether tert-butylhydroquinone enhanced angiogenesis and astrocyte activation through Nrf2 pathway. Wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2−/−) mice were subjected to permanent distal middle cerebral artery occlusion (dMCAO). We established 6 experimental groups (sham Nrf2+/+ group, vehicle Nrf2+/+ group, tBHQ Nrf2+/+ group; sham Nrf2−/− group, vehicle Nrf2−/− group, and tBHQ Nrf2−/− group). The infarct volume, neurological function, microvessel density (MVD), astrocytic endfeet covered ratio and the expression of Nrf2, HO-1 and VEGF in the ischemic brain were measured at...
Source: Microvascular Research - July 5, 2019 Category: Biochemistry Source Type: research
Side Stream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis
ConclusionsSSc patients showed decreased oral vasculature compared to controls. SDF imaging has shown the ability to be a useful diagnostic tool in the assessment of SSc. (Source: Microvascular Research)
Source: Microvascular Research - July 1, 2019 Category: Biochemistry Source Type: research
A new approach to the analysis of skin blood flow oscillations in human
Publication date: Available online 27 June 2019Source: Microvascular ResearchAuthor(s): Andrey Grinevich, Arina Tankanag, Irina Tikhonova, Nikolay ChemerisAbstractIt is considered that there are six non-overlapping frequency intervals with constant boundaries. These intervals correspond to different mechanisms of skin blood flow regulation. The boundaries do not depend on functional conditions but this statement should be verified. Also it remains unclear how the oscillatory components of skin blood flow are related. Thus the study is aimed to verify statistically the boundaries of frequency intervals, to test the hypothes...
Source: Microvascular Research - June 27, 2019 Category: Biochemistry Source Type: research
Publisher’s Note
Publication date: Available online 26 June 2019Source: Microvascular ResearchAuthor(s): (Source: Microvascular Research)
Source: Microvascular Research - June 26, 2019 Category: Biochemistry Source Type: research
Exploring the microcirculatory effects of an exercise programme including aerobic and resistance training in people with limited cutaneous systemic sclerosis
ConclusionsOur results suggest that a combined exercise protocol (aerobic and RT) was effective in improving endothelial-dependent reactivity in people with lcSSc. The next step would be to explore its clinical- and cost- effectiveness. Therefore, we recommend a large, community-based intervention against standard pharmacotherapy only, which would assess these important factors and support a change in therapeutic protocols and guidelines for this clinical population.Trial registrationClinicalTrials.gov (NCT number): NCT03058887, February 23, 2017, https://clinicaltrials.gov/ct2/show/NCT03058887?term=NCT03058887&rank=1 (Sou...
Source: Microvascular Research - June 18, 2019 Category: Biochemistry Source Type: research
