Journal of the Peripheral Nervous System This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rasch‐built Overall Disability Scale for Multifocal motor neuropathy (MMN‐RODS©)
Abstract Clinical trials in MMN have often used ordinal‐based measures that may not accurately capture changes. We aimed to construct a disability interval outcome measure specifically for MMN using the Rasch model and to examine its clinimetric properties. A total of 146 preliminary activity and participation items were assessed twice (reliability studies) in 96 clinically stable MMN patients. These patients also assessed the ordinal‐based overall‐disability sum‐score (construct, sample‐dependent validity). The final Rasch‐built overall‐disability scale for MMN (MMN‐RODS©) was serially applied in 26 patie...
Source: Journal of the Peripheral Nervous System - June 1, 2015 Category: Neurology Authors: Els K. Vanhoutte, Catharina G. Faber, Sonja I. van Nes, Elisabeth A. Cats, W. Ludo Van der Pol, Kenneth C. Gorson, P.A. van Doorn, David R. Cornblath, Leonard H. van den Berg, Ingemar S.J. Merkies, Tags: RESEARCH REPORT Source Type: research

Safety and efficacy of ranirestat in patients with mild‐to‐moderate diabetic sensorimotor polyneuropathy
We examined the efficacy and safety of ranirestat in patients with diabetic sensorimotor polyneuropathy (DSPN). Patients (18–75 years) with stable type 1/2 diabetes mellitus and DSPN were eligible for this global, double‐blind, phase II/III study (ClinicalTrials.gov NCT00927914). Patients (n=800) were randomized 1:1:1 to placebo, ranirestat 40 mg/day or 80 mg/day (265:264:271). Change in peroneal motor velocity (PMNCV) from baseline to 24 months was the primary endpoint with a goal improvement vs. placebo ≥1.2 m/s. Other endpoints included symptoms, quality‐of‐life, and safety. 633 patients completed the stud...
Source: Journal of the Peripheral Nervous System - June 1, 2015 Category: Neurology Authors: Michael Polydefkis, Joseph Arezzo, Marshall Nash, Vera Bril, Aziz Shaibani, Robert J Gordon, Kate L Bradshaw, Roderick WJ Junor, Tags: RESEARCH REPORTS Source Type: research

Systematic review of exercise for Charcot‐Marie‐Tooth disease
Abstract Charcot‐Marie‐Tooth disease (CMT) is a slowly progressive hereditary degenerative disease and one of the most common neuromuscular disorders. Exercise may be beneficial to maintain strength and function for people with CMT, however, no comprehensive evaluation of the benefits and risks of exercise have been conducted. A systematic review was completed searching numerous electronic databases from earliest records to February 2015. Studies of any design including participants of any age with confirmed diagnosis of CMT that investigated the effects of exercise were eligible for inclusion. Of 13,301 articles ident...
Source: Journal of the Peripheral Nervous System - May 22, 2015 Category: Neurology Authors: Amy D. Sman, Daniel Hackett, Maria Fiatarone Singh, Ché Fornusek, Manoj P. Menezes, Joshua Burns Tags: Review Source Type: research

Patterns and severity of vincristine‐induced peripheral neuropathy in children with acute lymphoblastic leukemia
Abstract Vincristine, a critical component of combination chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL), can lead to vincristine‐induced peripheral neuropathy (VIPN). Longitudinal VIPN assessments were obtained over 12 months from newly diagnosed children with ALL (N=128) aged 1–18 years who received vincristine at one of four academic children's hospitals. VIPN assessments were obtained using the Total Neuropathy Score‐Pediatric Vincristine (TNS©‐PV), National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE©), Balis© grading scale, and Pediatric Neuropathic Pain ...
Source: Journal of the Peripheral Nervous System - May 15, 2015 Category: Neurology Authors: Ellen M. Lavoie Smith, Lang Li, ChienWei Chiang, Karin Thomas, Raymond J. Hutchinson, Elizabeth M. Wells, Richard H. Ho, Jodi Skiles, Arindom Chakraborty, Celia M. Bridges, Jamie Renbarger Tags: Research Report Source Type: research

When is facial diplegia regarded as a variant of Guillain‐Barré syndrome?
This study aimed to characterize and determine the incidence of this FD‐predominant GBS variant. The clinical and serological information of 900 consecutive patients were reviewed. In total, eight patients were identified between January 2007 and December 2010 as having FD accompanied by some features of GBS. These features were subjective sensory symptoms such as distal paresthesia (7/8, 88%), albumin‐cytological (A/C) dissociation (7/8, 88%), antecedent infection (6/8, 75%), and minor nerve conduction study (NCS) abnormalities (5/7, 71%). One patient presented with the typical NCS feature of demyelinating neuropathy....
Source: Journal of the Peripheral Nervous System - May 15, 2015 Category: Neurology Authors: Jong Kuk Kim, Sun Young Oh, Eun Hee Sohn, Yoon Ho Hong, Sung Man Jun, Jong Seok Bae Tags: Research Report Source Type: research

Chronic inflammatory demyelinating polyneuropathy with membranous nephropathy
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 15, 2015 Category: Neurology Authors: Anna Hiu Yi Wong, Norito Kokubun, Yuki Fukami, Kazuki Miyaji, Nobuhiro Yuki Tags: Letter to the Editor Source Type: research

Genetic determinants of chronic oxaliplatin‐induced peripheral neurotoxicity: a genome‐wide study replication and meta‐analysis
Abstract We aimed at validating the role of genetic variants identified by a recent genome‐wide association study as determinants of chronic oxaliplatin‐induced peripheral neurotoxicity (OXAIPN). Eight polymorphisms (rs10486003, rs2338, rs843748, rs797519, rs4936453, rs12023000, rs17140129, rs6924717) were genotyped in a total of 150 colorectal cancer patients of Caucasian origin receiving oxaliplatin‐based chemotherapy. The severity grade of chronic OXAIPN was assessed by NCI‐CTC criteria and the clinical version of the Total Neuropathy Score© (TNSc©). None of the polymorphisms investigated was found associated ...
Source: Journal of the Peripheral Nervous System - April 10, 2015 Category: Neurology Authors: Salvatore Terrazzino, Andreas A. Argyriou, Sarah Cargnin, Anna G. Antonacopoulou, Chiara Briani, Jordi Bruna, Roser Velasco, Paola Alberti, Marta Campagnolo, Sara Lonardi, Diego Cortinovis, Marina Cazzaniga, Cristina Santos, Haralabos P. Kalofonos, Pier L Tags: Research Report Source Type: research

CIDP‐like neuropathies in graft versus host disease
This study reviews the literature data and reports one additional case. Materials and MethodsA systematic review of the CIDP‐like neuropathies associated with GVHD was conducted until January 2015, analyzing the clinical presentation and the response to different therapeutic regimens. ResultsNineteen patients with CIDP‐like neuropathies associated with GVHD have been reported in literature including the present one. Fourteen subjects fulfilled the criteria for CIDP, while two cases presented with an asymmetric motor onset and one showed motor involvement only associated with anti‐ganglioside antibodies. In addition, ...
Source: Journal of the Peripheral Nervous System - April 10, 2015 Category: Neurology Authors: Dario Cocito, Alberto Romagnolo, Michela Rosso, Erdita Peci, Leonardo Lopiano, Aristide Merola Tags: Review Source Type: research

An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model
This study points to a relatively simple and potentially effective therapeutic option to reduce the neurotoxic effects of chemotherapy. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - April 10, 2015 Category: Neurology Authors: Jae Sung Park, Sangri Kim, Ahmet Hoke Tags: Research Report Source Type: research

Transtyretin Asp38Tyr: a new mutation associated to a late onset neuropathy
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - April 10, 2015 Category: Neurology Authors: Carolina Lavigne Moreira, Vanessa Daccach Marques, Charles Marques Lourenço, Daisy Isabel Cabrini, Jose Cuellar Nuñez, Ronaldo Francisco Herrera, Wilson Marques Tags: Case Report Source Type: research

Effect of diet induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice
Abstract We determined the impact diet induced obesity (DIO) and types 1 and 2 diabetes has on peripheral neuropathy with emphasis on corneal nerve structural changes in C57Bl/6J mice. Endpoints examined included nerve conduction velocity, response to thermal and mechanical stimuli and innervation of the skin and cornea. DIO mice and to a greater extent type 2 diabetic mice were insulin resistant. DIO and both types 1 and 2 diabetic mice developed motor and sensory nerve conduction deficits. In the cornea of DIO and type 2 diabetic mice there was a decrease in sub‐epithelial corneal nerves, innervation of the corneal epi...
Source: Journal of the Peripheral Nervous System - April 10, 2015 Category: Neurology Authors: Matthew S. Yorek, Alexander Obrosov, Hanna Shevalye, Amey Holmes, Matthew M. Harper, Randy H. Kardon, Mark A. Yorek Tags: Research Report Source Type: research

2015 Peripheral Nerve Society Biennial Meeting June 27–July 2, 2015 Québec City, Québec, Canada
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - March 1, 2015 Category: Neurology Tags: Abstract Source Type: research

Improving assessment in small fiber neuropathy
In conclusion, the 32‐item SFN‐RODS© is a disease‐specific interval measure suitable for detecting activity limitations and participation restrictions in patients with SFN. The 13‐item SFN‐SIQ© was transformed through Rasch to an interval measure. The use of these scales is recommended in future clinical interventional trials involving patients with SFN. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - March 1, 2015 Category: Neurology Authors: Brigitte A. Brouwer, Mayienne Bakkers, Janneke G.J. Hoeijmakers, Catharina G. Faber, Ingemar S.J. Merkies Tags: RESEARCH REPORT Source Type: research

Comparing the NIS vs MRC and INCAT sensory scale through Rasch analyses
Abstract We performed a comparison between NISsensory versus the mISS, and NISmotor versus the MRCsumscore in patients with Guillain‐Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and IgM monoclonal gammopathy of undetermined significance related polyneuropathy (MGUSP). The ordinal data were subjected to Rasch analyses, creating Rasch‐transformed (RT)‐intervals for all measures. Comparison between measures was based on validity/reliability with an emphasis on responsiveness (using the patient's level of change related to the individually obtained varying standard errors for m...
Source: Journal of the Peripheral Nervous System - March 1, 2015 Category: Neurology Authors: Thomas H.P. Draak, Els K. Vanhoutte, Sonja I. van Nes, Kenneth C. Gorson, W. Ludo Van der Pol, Nicolette C. Notermans, Eduardo Nobile‐Orazio, Jean‐Marc Léger, Peter Y.K. Van den Bergh, Giuseppe Lauria, Vera Bril, Hans Katzberg, Michael P.T. Lunn, Jea Tags: RESEARCH REPORT Source Type: research

Nerve ultrasonography in early Guillain‐Barré syndrome: a need for large prospective studies
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - February 8, 2015 Category: Neurology Authors: José Berciano, Elena Gallardo, María J. Sedano, Pedro Orizaola, Pascual Sánchez‐Juan, Andrea González‐Suárez, Antonio García, Nuria Terán‐Villagrá, María Ruiz‐Soto, Rosa Landeras‐Álvaro, María T. Berciano, Miguel Lafarga Tags: LETTER TO THE EDITOR Source Type: research