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Guillain ‐Barré syndrome in the elderly
In conclusion, Elderly patients, and especially old‐old patients, with GBS have more severe disease with slower recovery than do younger patients. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Stojan Peric, Ivana Berisavac, Olivera Stojiljkovic Tamas, Sonja Rajic, Milica Babic, Milan Cvijanovic, Aleksandra Dominovic ‐Kovacevic, Ivana Basta, Ljiljana Beslac‐Bumbasirevic, Dragana Lavrnic Tags: RESEARCH REPORT Source Type: research

Painful Diabetic Neuropathy Anxiety Rasch ‐Transformed Questionnaire (PART‐Q30©)
Abstract The association between painful diabetic neuropathy (PDN) and anxiety has been acknowledged using various anxiety scales capturing various fear entities. It has never been examined whether these generally applied anxiety questionnaires could be pooled to construct one overall anxiety metric. After completion by a cohort of 151 patients with PDN, data obtained from seven generally applied fear scales were stacked (n = 88 items) and subjected to Rasch analyses (pre‐PART‐Q88) to create the PDN overall Anxiety Questionnaire (PART‐Q30©). We subsequently examined the impact of the final constructed PART‐Q30© o...
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Charlotte C. Geelen, Brigitte A. Brouwer, Janneke G. J. Hoeijmakers, Catharina G. Faber, Ingemar S. J. Merkies, Jeanine A. Verbunt Tags: RESEARCH REPORT Source Type: research

Fampridine ‐PR (prolonged released 4‐aminopyridine) is not effective in patients with inflammatory demyelination of the peripheral nervous system
In this study, Fampridine‐PR failed to improve CIDP based on clinical measures and nerve conduction studies. Our findings suggest that Fampridine‐PR appears to be ineffective in demyelinating polyneuropathies. These observations may indicate a more complex mode of action beyond improving action potential conduction in demyelinated axons. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Verena ‐Isabell Leussink, Mark Stettner, Clemens Warnke, Hans‐Peter Hartung Tags: RESEARCH REPORT Source Type: research

Transthyretin familial amyloid polyneuropathy (TTR ‐FAP) in Mallorca: A comparison between late‐ and early‐onset disease
Abstract The age of onset (AO) of hereditary ATTR Amyloidosis (hATTR) is known to vary between populations, with differing characteristics reported according to AO in endemic/non‐endemic foci. This was a retrospective study of patients with early AO (<50 years) and late AO (≥50 years) hATTR at our center in Mallorca. Data were collected on patient demographics, clinical disease manifestation, and physical symptoms. A total of 95 patients were analyzed, with mean follow‐up of 9 years from diagnosis. The early AO group included 53 patients (33 male) and the late AO group included 42 patients (21 male). Neurologi...
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Juan Buades ‐Reinés, Manuel Raya‐Cruz, Cristina Gallego‐Lezaún, Tomás Ripoll‐Vera, Mercedes Usón‐Martín, Hernán Andreu‐Serra, Eugenia Cisneros‐Barroso Tags: RESEARCH REPORT Source Type: research

Transthyretin familial amyloid polyneuropathy (TTR‐FAP) in Mallorca: A comparison between late‐ and early‐onset disease
Abstract The age of onset (AO) of hereditary ATTR Amyloidosis (hATTR) is known to vary between populations, with differing characteristics reported according to AO in endemic/non‐endemic foci. This was a retrospective study of patients with early AO (<50 years) and late AO (≥50 years) hATTR at our center in Mallorca. Data were collected on patient demographics, clinical disease manifestation, and physical symptoms. A total of 95 patients were analyzed, with mean follow‐up of 9 years from diagnosis. The early AO group included 53 patients (33 male) and the late AO group included 42 patients (21 male). Neurologi...
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Juan Buades‐Reinés, Manuel Raya‐Cruz, Cristina Gallego‐Lezaún, Tomás Ripoll‐Vera, Mercedes Usón‐Martín, Hernán Andreu‐Serra, Eugenia Cisneros‐Barroso Tags: RESEARCH REPORT Source Type: research

Serum micronutrients and prealbumin during development and recovery of chemotherapy‐induced peripheral neuropathy
Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) is a frequent adverse event. Nutritional status can become impaired in cancer patients, potentially contributing to neuropathy's evolution. Our aim was to evaluate serum micronutrients and prealbumin in a cohort of 113 solid‐cancer patients receiving platinum and taxane compounds during the development and recovery of neuropathy, up to one year after finishing treatment. CIPN was graded according with Total Neuropathy Score© and NCI.CTCv3, at T0 (baseline), T1 (1–3 months) and T12 (12 months) after chemotherapy. CIPN was classified as asymptomatic (< gr...
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Roser Velasco, Cristina Santos, Gemma Soler, Miguel Gil‐Gil, Sonia Pernas, Maica Galan, Ramon Palmero, Jordi Bruna Tags: RESEARCH REPORTS Source Type: research

A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy and common variable immune deficiency
We report a case showing overlap of both of these syndromes plus associated clinical features of common variable immune deficiency, scleroderma and endocrinopathy that could also be mutation associated. ResultsOur patient was found to be heterozygous for a previously unreported frameshift mutation, c.1635_1637delCAA p.(Asn545del) in the DNMT1 gene exon 20. DiscussionThis case displays both the first frameshift mutation described in the literature which is associated with a phenotype with a high degree of overlap between HSAN1E and ADCA‐DN and early age of onset (c. 8 yrs). Our case is also of interest as the patient di...
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Robin Fox, John Ealing, Helen Murphy, David P Gow, David Gosal Tags: CASE REPORT Source Type: research

Are electrophysiological criteria useful in distinguishing childhood demyelinating neuropathies?
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Tags: CORRIGENDUM Source Type: research

Subcutaneous vs. intravenous immunoglobulin in CIDP: pharmacokinetic and clinical response
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Dario Cocito, Alberto Romagnolo, Erdita Peci, Michela Rosso, Leonardo Lopiano, Paola Milla, Aristide Merola Tags: LETTER TO THE EDITOR Source Type: research

Guillain‐Barré syndrome in the elderly
In conclusion, Elderly patients, and especially old‐old patients, with GBS have more severe disease with slower recovery than do younger patients. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Authors: Stojan Peric, Ivana Berisavac, Olivera Stojiljkovic Tamas, Sonja Rajic, Milica Babic, Milan Cvijanovic, Aleksandra Dominovic‐Kovacevic, Ivana Basta, Ljiljana Beslac‐Bumbasirevic, Dragana Lavrnic Tags: RESEARCH REPORT Source Type: research

Issue Information – Table of Contents
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Issue Information – Editorial Board
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - May 31, 2016 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Screening for SH3TC2 gene mutations in a series of demyelinating recessive Charcot ‐Marie‐Tooth disease (CMT4)
Abstract Charcot‐Marie‐Tooth disease type 4C (CMT4C) is an autosomal recessive (AR) demyelinating neuropathy associated to SH3TC2 mutations, characterized by early onset, spine deformities, and cranial nerve involvement. We screened 43 CMT4 patients (36 index cases) with AR inheritance, demyelinating nerve conductions, and negative testing for PMP22 duplication, GJB1 and MPZ mutations, for SH3TC2 mutations. Twelve patients (11 index cases) had CMT4C as they carried homozygous or compound heterozygous mutations in SH3TC2. We found six mutations: three nonsense (p.R1109*, p.R954*, p.Q892*), one splice‐site (c.805+2T>...
Source: Journal of the Peripheral Nervous System - May 26, 2016 Category: Neurology Authors: Giuseppe Piscosquito, Paola Saveri, Stefania Magri, Claudia Ciano, Claudia Gandioli, Michela Morbin, Daniela Di Bella, Isabella Moroni, Franco Taroni F, Davide Pareyson Tags: RESEARCH REPORT Source Type: research

Severe, reversible nelarabine ‐induced neuropathy and myelopathy
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - April 26, 2016 Category: Neurology Authors: Paola Alberti, Matteo Parma, Pietro Pioltelli, Enrico Maria Pogliani, Elisabetta Terruzzi, Alessandra Stasia, Elisa Doni, Caterina Cecchetti, Guido Cavaletti Tags: LETTER TO THE EDITOR Source Type: research

Abstracts
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - April 5, 2016 Category: Neurology Tags: Abstracts Source Type: research