Ultrasonography of the peripheral nervous system in the early stage of Guillain‐Barré syndrome
The objective of this study was to prove the role of ultrasonography in acute phase of Guillain‐Barré syndrome (GBS). Systematic ultrasonic measurements of several peripheral nerves including the vagal nerve as well as the 6th cervical nerve root were performed in 18 patients with GBS at day 1–3 after symptom onset and compared to 21 healthy controls. Nerve conduction studies of corresponding nerves were undertaken. Consequently, significant differences between the groups were found in compound muscle action potential amplitudes, distal motor latency, F‐wave latency and persistency. Ultrasonic cross‐sectional area...
Source: Journal of the Peripheral Nervous System - June 1, 2014 Category: Neurology Authors: Alexander Grimm, Bernhard Decard, Hubertus Axer Tags: RESEARCH REPORT Source Type: research

Guillain‐Barré syndrome associated with CASPR2 antibodies: two paediatric cases
We report 2 cases of ganglioside antibody‐negative paediatric GBS associated with CASPR2 antibodies. Both patients made a full clinical recovery. The tissue distribution and function of CASPR2 make it a biologically plausible autoimmune target in GBS and its clincial relevance in GBS should be determined in further studies. (Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - June 1, 2014 Category: Neurology Authors: Richard E. Rosch, Alasdair Bamford, Yael Hacohen, Elizabeth Wraige, Angela Vincent, Leena Mewasingh, Ming Lim Tags: CASE REPORT Source Type: research

Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin‐induced diabetic C57Bl/6J mice
Abstract We sought to determine the impact that duration of hyperglycemia and control has on corneal nerve fiber density in relation to standard diabetic neuropathy endpoints. Control and streptozotocin‐diabetic C57Bl/6J mice were analyzed after 4, 8, 12 and 20 weeks. For the 20 week time point, five groups of mice were compared: control, untreated diabetic, and diabetic treated with insulin designated as having either poor glycemic control, good glycemic control or poor glycemic control switched to good glycemic control. Hyperglycemia was regulated by use of insulin releasing pellets. Loss of corneal nerves in the sub...
Source: Journal of the Peripheral Nervous System - June 1, 2014 Category: Neurology Authors: Matthew S. Yorek, Alexander Obrosov, Hanna Shevalye, Sergey Lupachyk, Matthew M. Harper, Randy H. Kardon, Mark A. Yorek Tags: RESEARCH REPORT Source Type: research

The normal sensibility of the hand declines with age ‐ a proclamation for the use of delta 2‐point discrimination values for sensibility assessment after nerve reconstruction
Abstract The scores used to evaluate sensibility after digital nerve reconstruction do not take the patient's age into consideration, although there is evidence that the outcome after digital nerve reconstruction is age‐dependent. However, it is not clear if the normal sensibility of the hand is also age‐dependent, since the existing studies have major limitations. We evaluated the normal sensibility of the hand in 232 patients using static and moving 2‐point discrimination (2PD) tests and the Semmes‐Weinstein‐monofilament test. We found the climax of sensibility in the third decade with age‐dependent deteriora...
Source: Journal of the Peripheral Nervous System - June 1, 2014 Category: Neurology Authors: Daniel Schmauss, Tom Finck, Kai Megerle, Hans‐Guenther Machens, Joern A. Lohmeyer Tags: Research Report Source Type: research

Announcement
(Source: Journal of the Peripheral Nervous System)
Source: Journal of the Peripheral Nervous System - June 1, 2014 Category: Neurology Tags: ANNOUNCEMENT Source Type: research