Serum micronutrients and prealbumin during development and recovery of chemotherapy‐induced peripheral neuropathy

Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) is a frequent adverse event. Nutritional status can become impaired in cancer patients, potentially contributing to neuropathy's evolution. Our aim was to evaluate serum micronutrients and prealbumin in a cohort of 113 solid‐cancer patients receiving platinum and taxane compounds during the development and recovery of neuropathy, up to one year after finishing treatment. CIPN was graded according with Total Neuropathy Score© and NCI.CTCv3, at T0 (baseline), T1 (1–3 months) and T12 (12 months) after chemotherapy. CIPN was classified as asymptomatic (< grade 2) or symptomatic (≥2). CIPN recovery was defined as ≥1 grade improvement at T12. Symptomatic CIPN developed in 52% of patients. Symptomatic patients presented a higher increase in TNSc© (p < 0.001), in TNSr© (p < 0.001), and decrease in sural (p < 0.001) and radial nerve conduction (p < 0.001). No significant differences with any of the micronutrients were observed along T0‐T1 period between severity or chemotherapy groups. By T12, symptomatic patients without recovery had a lowering in vitamin E levels (p = 0.019) and prealbumin (p = 0.062) compared to those symptomatic that improved. A correlation between the variation of vitamin E and prealbumin at T0‐T1 (r = 0.626, p = 0.001) and T1‐T12 (r = 0.411, p = 0.06) was observed. After chemotherapy treatment, the improvement of patients display...
Source: Journal of the Peripheral Nervous System - Category: Neurology Authors: Tags: RESEARCH REPORTS Source Type: research