Neuroglial interactions underpinning myelin plasticity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 22, 2017 Category: Neurology Authors: Omar de Faria, E.A. Claudia Pama, Kimberley Evans, Aryna Luzhynskaya, Ragnhildur T K áradóttir Tags: Review Article Source Type: research
Age ‐dependent expression of Nav1.9 channels in medial prefrontal cortex pyramidal neurons in rats
ABSTRACT
Developmental changes that occur in the prefrontal cortex during adolescence alter behavior. These behavioral alterations likely stem from changes in prefrontal cortex neuronal activity, which may depend on the properties and expression of ion channels. Nav1.9 sodium channels conduct a Na+ current that is TTX resistant with a low threshold and noninactivating over time. The purpose of this study was to assess the presence of Nav1.9 channels in medial prefrontal cortex (mPFC) layer II and V pyramidal neurons in young (20‐day old), late adolescent (60‐day old), and adult (6‐ to 7‐month old) rats. First, we d...
Source: Journal of Neurobiology - September 22, 2017 Category: Neurology Authors: Maciej Gawlak, Bart łomiej Szulczyk, Adam Berłowski, Katarzyna Grzelka, Anna Stachurska, Justyna Pełka, Katarzyna Czarzasta, Maciej Małecki, Przemysław Kurowski, Ewa Nurowska, Paweł Szulczyk Tags: Research Article Source Type: research
Myelin Plasticity, Neural Activity and Traumatic Neural Injury
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 19, 2017 Category: Neurology Authors: Bethany R. Kondiles, Philip J. Horner Tags: Review Article Source Type: research
The where, what, and when of membrane protein degradation in neurons
ABSTRACT
Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ens...
Source: Journal of Neurobiology - September 19, 2017 Category: Neurology Authors: Eugene Jennifer Jin, Ferdi Ridvan Kiral, Peter Robin Hiesinger Tags: Review Article Source Type: research
Myelin Development, Plasticity, and Pathology in the Auditory System
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 19, 2017 Category: Neurology Authors: Patrick Long, Guoqiang Wan, Michael T. Roberts, Gabriel Corfas Tags: Review Article Source Type: research
Issue Information
(Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 18, 2017 Category: Neurology Tags: Issue Information Source Type: research
Cover Image
Cover: The cover, by Aswati Subramanian et al., is based on the Research Article Remodeling of peripheral nerve ensheathment during the larval‐to‐adult transition in Drosophila, DOI: 10.1002/dneu.22502. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 18, 2017 Category: Neurology Authors: Aswati Subramanian, Matthew Siefert, Soumya Banerjee, Kumar Vishal, Kayla A. Bergmann, Clay C.M. Curts, Meredith Dorr, Camillo Molina, Joyce Fernandes Tags: Cover Image Source Type: research
Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress
ABSTRACT
Emerging evidence shows that oligodendrogenesis and myelination are highly responsive to behavioral experience, including physical activity and social experience. This form of myelin plasticity is being increasingly appreciated and examined in the prefrontal cortex (PFC), a critical brain region involved in complex emotional and cognitive behavior. However, it remains unclear whether myelination in other brain regions is affected by behavioral experience. Here we report that exposure to 4 weeks of chronic variable stress induced anxiety‐ and depressive‐like behavior in male adult mice. In concert with these be...
Source: Journal of Neurobiology - September 14, 2017 Category: Neurology Authors: Jia Liu, Karen Dietz, Georgia E. Hodes, Scott J. Russo, Patrizia Casaccia Tags: Research Article Source Type: research
Intrinsic and adaptive myelination —A sequential mechanism for smart wiring in the brain
ABSTRACT
The concept of adaptive myelination—myelin plasticity regulated by activity—is an important advance for the field. What signals set up the adaptable pattern in the first place? Here we review work that demonstrates an intrinsic pathway within oligodendrocytes requiring only an axon‐shaped substrate to generate multilayered and compacted myelin sheaths of a physiological length. Based on this, we discuss a model we proposed in 2015 which argues that myelination has two phases—intrinsic and then adaptive—which together generate “smart wiring,” in which active axons become more myelinated. This model ex...
Source: Journal of Neurobiology - September 14, 2017 Category: Neurology Authors: Marie E. Bechler, Matthew Swire, Charles ffrench ‐Constant Tags: Review Article Source Type: research
GABA type A receptor trafficking and the architecture of synaptic inhibition
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 13, 2017 Category: Neurology Authors: Joshua M. Lorenz ‐Guertin, Tija C. Jacob Tags: Review Article Source Type: research
Age ‐dependent expression of Nav1.9 channels in medial prefrontal cortex (mPFC) pyramidal neurons in rats
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 1, 2017 Category: Neurology Authors: Maciej Gawlak, Bart łomiej Szulczyk, Adam Berlowski, Katarzyna Grzelka, Anna Stachurska, Justyna Pelka, Katarzyna Czarzasta, Maciej Malecki, Przemyslaw Kurowski, Ewa Nurowska, Pawel Szulczyk Tags: Research Article Source Type: research
Chondroitin Sulfate Proteoglycans Negatively Regulate the Positioning of Mitochondria and Endoplasmic Reticulum to Distal Axons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 1, 2017 Category: Neurology Authors: Rajiv Sainath, Lorena Armijo ‐Weingart, Andrea Ketscheck, Zhuxuan Xu, Shuxin Li, Gianluca Gallo Tags: Research Article Source Type: research
Wide ‐spread Transcriptional Alternations in Oligodendrocytes in the Adult Mouse Brain following Chronic Stress
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 1, 2017 Category: Neurology Authors: Jia Liu, Karen Dietz, Georgia E. Hodes, Scott J. Russo, Patrizia Casaccia Tags: Research Article Source Type: research
The Where, What and When of Membrane Protein Degradation in Neurons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - September 1, 2017 Category: Neurology Authors: Eugene Jennifer Jin, Ferdi Ridvan Kiral, Peter Robin Hiesinger Tags: Review Article Source Type: research
To mdivi ‐1 or not to mdivi‐1: Is that the question?
This study raises serious issues regarding the interpretation of data addressing the effects of mdivi‐1 as reflective of the inhibition of Drp1 and thus fission. This commentary considers the evidence for and against mdivi‐1 as an inhibitor of Drp1 and presents the following considerations; (1) the activity of mdivi‐1 toward Drp1 GTPase activity requires further biochemical investigation, (2) as there is a large body of literature using mdivi‐1 in vitro with effects as predicted for inhibition of Drp1 and mitochondrial fission, reviewed herein, the evidence is in favor of mdivi‐1's originally described bioactivit...
Source: Journal of Neurobiology - August 26, 2017 Category: Neurology Authors: George Smith, Gianluca Gallo Tags: Review Article Source Type: research
