The where, what, and when of membrane protein degradation in neurons

ABSTRACT
Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. © 2017 Wiley Periodicals, Inc. Develop Neurobiol, 2017

Source: Journal of Neurobiology - September 19, 2017 Category: Neurology Authors: Eugene Jennifer Jin, Ferdi Ridvan Kiral, Peter Robin Hiesinger Tags: Review Article Source Type: research