FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning
ABSTRACT
A prevalent developmental mechanism for the assignment of cell identities is the production of spatiotemporal concentration gradients of extracellular signaling molecules that are interpreted by the responding cells. One of such signaling systems is the Shh gradient that controls neuronal subtype identity in the ventral spinal cord. Using loss and gain of function approaches in chick and mouse embryos, we show here that the fibroblast growth factor (FGF) signaling pathway is required to restrict the domains of ventral gene expression as neuroepithelial cells become exposed to Shh during caudal extension of the emb...
Source: Journal of Neurobiology - December 8, 2015 Category: Neurology Authors: Aixa V. Morales, Sergio Espeso‐Gil, Inmaculada Ocaña, Francisco Nieto‐Lopez, Elena Calleja, Paola Bovolenta, Mark Lewandoski, Ruth Diez del Corral Tags: Research Article Source Type: research
Oligodendroglial defects during quakingviable cerebellar development
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - December 1, 2015 Category: Neurology Authors: Kenneth R Myers, Guanglu Liu, Yue Feng, James Q. Zheng Tags: Research Article Source Type: research
Impaired cortical neurogenesis in plexin ‐B1 and ‐B2 double deletion mutant
We examined the function of Semaphorin receptors Plexin‐B1 and ‐B2 in corticogenesis by generating double mutants, whereby Plexin‐B2 was conditionally ablated in the developing brain in a Plexin‐B1 null mutant background. Absence of both Plexin‐Bs resulted in cortical thinning, particularly in the caudomedial cortex. Plexin‐B1/B2 double, but not single, mutants exhibited a reduced neural progenitor pool, attributable to decreased proliferation and an altered division mode favoring cell cycle exit. This resulted in deficient production of neurons throughout the neurogenic period, proportionally affecting all cor...
Source: Journal of Neurobiology - November 30, 2015 Category: Neurology Authors: Nicolas Daviaud, Karen Chen, Yong Huang, Roland H. Friedel, Hongyan Zou Tags: Research Article Source Type: research
Maternal separation and early stress cause long ‐lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats
In this study, we seek to evaluate potential morphological changes in neurons of the frontal cortex (FCx) and nucleus accumbens (NAcc), in the expression of receptors and enzymes of the endocannabinoid and dopamine systems and in second messengers, such as Akt, in adult rats subjected to MS and early stress (MS + ES; 2 × 180 min daily) vs. nonseparated rats (NMS). Results showed that MS + ES induces higher D2R expression and lower D3R, FAAH, and MAGL expression compared with NMS rats. Alterations in total dendritic length were also detected and were characterized by increases in the NAcc while there were decreases...
Source: Journal of Neurobiology - November 29, 2015 Category: Neurology Authors: Antonio Romano ‐López, Mónica Méndez‐Díaz, Fabio García García, Citlalli Regalado‐Santiago, Alejandra E. Ruiz‐Contreras, Oscar Prospéro‐García Tags: Research Article Source Type: research
FGF signalling enhances a Sonic Hedgehog negative feedback loop at the initiation of spinal cord ventral patterning
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 24, 2015 Category: Neurology Authors: Aixa V. Morales, Sergio Espeso‐Gil, Inmaculada Ocaña, Francisco Nieto‐Lopez, Elena Calleja, Paola Bovolenta, Mark Lewandoski, Ruth Diez del Corral Tags: Research Article Source Type: research
Neurotrophin ‐dependent plasticity of neurotransmitter segregation in the rat superior cervical ganglion in vivo
ABSTRACT
Neurons are able to segregate transmitters to different axon endings. Segregation is a plastic neuronal feature; it can be modulated by synaptic environment. We have demonstrated that neurotrophin and other cellular factors regulate segregation in sympathetic neurons in culture. Herein we tested the hypothesis that sympathetic neurons in vivo are also capable to exhibit neurotrophin‐dependent plasticity of segregation. To explore the effect of neurotrophin on segregation, we reduced ganglionic NGF content by the transection of postganglionic nerves (axotomy) of the superior cervical ganglia. By immunohistochemis...
Source: Journal of Neurobiology - November 23, 2015 Category: Neurology Authors: A. Vega, A. Cancino ‐Rodezno, P. Valle‐Leija, B.M. Sánchez‐Tafolla, D. Elinos, F. Cifuentes, M.A. Morales Tags: Research Article Source Type: research
Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 20, 2015 Category: Neurology Authors: K.T. Ahmed, D.W. Ali Tags: Research Article Source Type: research
Sp8 expression in putative neural progenitor cells in guinea pig and human cerebrum
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 20, 2015 Category: Neurology Authors: Xue‐Mei Zhang, Yan Cai, Fang Wang, Jun Wu, Lin Mou, Feng Zhang, Peter R. Patrylo, Aihua Pan, Chao Ma, Jin Fu, Xiao‐Xin Yan Tags: Research Article Source Type: research
Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 18, 2015 Category: Neurology Authors: Melissa Barber, Alessandra Pierani Tags: Review Article Source Type: research
Lmo4 and other LIM domain only factors are necessary and sufficient for multiple retinal cell type development
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 18, 2015 Category: Neurology Authors: Kangxin Jin, Dongchang Xiao, Bogi Andersen, Mengqing Xiang Tags: Research Article Source Type: research
Impaired cortical neurogenesis in Plexin‐B1 and ‐B2 double deletion mutant
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 18, 2015 Category: Neurology Authors: Nicolas Daviaud, Karen Chen, Yong Huang, Roland H. Friedel, Hongyan Zou Tags: Research Article Source Type: research
Neurotrophin‐dependent plasticity of neurotransmitter segregation in the rat superior cervical ganglion in vivo
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 13, 2015 Category: Neurology Authors: A. Vega, A. Cancino‐Rodezno, P. Valle‐Leija, B.M. Sánchez‐Tafolla, D. Elinos, F. Cifuentes, M.A. Morales Tags: Research Article Source Type: research
Nonsynaptic glycine release is involved in the early KCC2 expression
In this study, we found that chronically blocking glycine receptors (GlyR) by strychnine led to a loss of KCC2 expression, without affecting NKCC1 level. This effect was not dependent on the firing of Na+ action potentials but was mimicked by a Ca2+‐dependent PKC blocker. Blocking the vesicular release of neurotransmitters did not impinge on strychnine effect whereas blocking volume‐sensitive outwardly rectifying (VSOR) chloride channels reproduced the GlyR blockade, suggesting that KCC2 is controlled by a glycine release from progenitor radial cells in immature ventral spinal networks. Finally, we showed that the stry...
Source: Journal of Neurobiology - November 3, 2015 Category: Neurology Authors: Anne‐Emilie Allain, William Cazenave, Alain Delpy, Prisca Exertier, Christophe Barthe, Pierre Meyrand, Daniel Cattaert, Pascal Branchereau Tags: Research Article Source Type: research
Maternal separation and early stress cause long‐lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 1, 2015 Category: Neurology Authors: Q.F.B. Antonio Romano‐López, Mónica Méndez‐Díaz, Fabio García García, Citlalli Regalado‐Santiago, Alejandra E. Ruiz Contreras, Oscar Prospéro‐García Tags: Research Article Source Type: research
Netrin‐1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - October 31, 2015 Category: Neurology Authors: Shruti Jain, Kristy Welshhans Tags: Research Article Source Type: research
