LINE ‐1 Retrotransposons in Healthy and Diseased Human Brain
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - December 1, 2017 Category: Neurology Authors: Nicole A. Suarez, Angela Macia, Alysson R. Muotri Tags: Review Article Source Type: research
SHANK1 is Differentially Expressed during Development in CA1 Hippocampal Neurons and Astrocytes
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - December 1, 2017 Category: Neurology Authors: Sean M. Collins, Amogh P. Belagodu, Samantha L. Reed, Roberto Galvez Tags: Research Article Source Type: research
Compartment ‐specific dynamics and functions of autophagy in neurons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - December 1, 2017 Category: Neurology Authors: Vineet Vinay Kulkarni, Sandra Maday Tags: Review Article Source Type: research
The axonal endoplasmic reticulum: One organelle —many functions in development, maintenance, and plasticity
We describe the interactions between the ER and endosomes, mitochondria, and synaptic vesicles. Finally, we analyze available proteomic data of axonal preparations to reveal the dynamic functionality of the ER in axons during development. We suggest that the dynamic proteome and a validated axonal interactome, together with state‐of‐the‐art methodologies, may provide interesting research avenues in axon physiology that may extend to pathology and regeneration. © 2017 Wiley Periodicals, Inc. Develop Neurobiol, 2017 (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 19, 2017 Category: Neurology Authors: Alejandro Luarte, V íctor Hugo Cornejo, Francisca Bertin, Javiera Gallardo, Andrés Couve Tags: Review Article Source Type: research
Regulation of glycosaminoglycan biogenesis is critical for sensitive ‐period‐dependent vocal ontogeny
ABSTRACT
In the brain, the extracellular matrix (ECM) plays a central role during neural development and thus modulates critical‐period regulated behavioral ontogeny. The major components of the ECM are glycosaminoglycans (GAGs) including chondroitin sulfate (CS). However, the specific roles of GAGs in behavioral development are largely unknown. It has been shown that xylosides affect the biological functions of GAGs through modulating GAG biosynthesis. Particularly, xylosides affect GAG biosynthesis through priming of GAG chains (priming activity), competing with endogenous core proteins that carry GAG initiation sites ...
Source: Journal of Neurobiology - November 17, 2017 Category: Neurology Authors: Caitlin P. Mencio, Vy My Tran, Maritza V. Quintero, Mamoru Koketsu, Franz Goller, Balagurunathan Kuberan Tags: Research Article Source Type: research
Issue Information
(Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 17, 2017 Category: Neurology Tags: Issue Information Source Type: research
Cover Image
Cover: The cover, by Sanam Zarei et al., is based on the Research Article Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear, DOI: 10.1002/dneu.22544. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 17, 2017 Category: Neurology Authors: Sanam Zarei, Kasra Zarei, Bernd Fritzsch, Karen L. Elliott Tags: Cover Image Source Type: research
Identifying suitable reference genes for developing and injured mouse CNS tissues
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 14, 2017 Category: Neurology Authors: Dongchao Xu, Ajuan Liu, Xuan Wang, Ming Zhang, Zunyi Zhang, Tan Zhou, Mengsheng Qiu Tags: Research Article Source Type: research
Developmental retinal ganglion cell death and retinotopicity of the murine retinocollicular projection
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 14, 2017 Category: Neurology Authors: Jamie Beros, Jennifer Rodger, Alan R Harvey Tags: Research Article Source Type: research
The physical approximation of APP and BACE ‐1: A key event in alzheimer's disease pathogenesis
ABSTRACT
Alzheimer's disease (AD) is characterized by the accumulation of insoluble deposits of Amyloid β (Aβ) in brains. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) by β‐site secretase enzyme (BACE‐1) and γ‐secretase. Proteolytic processing of APP by BACE‐1 is the rate‐limiting step in Aβ production, and this pathway is a prime target for AD drug development. Both APP and BACE‐1 are membrane‐spanning proteins, transported via secretory and endocytic pathways; and the physical interaction of APP and BACE‐1 during trafficking is a key cell biological event initiating the...
Source: Journal of Neurobiology - November 13, 2017 Category: Neurology Authors: Jichao Sun, Subhojit Roy Tags: Review Article Source Type: research
Advances in noninvasive myelin imaging
ABSTRACT
Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods...
Source: Journal of Neurobiology - November 10, 2017 Category: Neurology Authors: Florence Heath, Samuel A. Hurley, Heidi Johansen ‐Berg, Cassandra Sampaio‐Baptista Tags: Review Article Source Type: research
The axonal endoplasmic reticulum: One organelle ‐ many functions in development, maintenance and plasticity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 1, 2017 Category: Neurology Authors: Alejandro Luarte, V íctor Hugo Cornejo, Francisca Bertin, Javiera Gallardo, Andrés Couve Tags: Review Article Source Type: research
To the End of the Line: Axonal mRNA transport and local translation in health and neurodegenerative disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 1, 2017 Category: Neurology Authors: Christopher J. Costa, Dianna E. Willis Tags: Review Article Source Type: research
The physical approximation of APP and BACE ‐1 ‐ a key event in Alzheimer's disease pathogenesis
(Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 1, 2017 Category: Neurology Authors: Jichao Sun, Subhojit Roy Tags: Review Article Source Type: research
Regulation of plasma membrane expansion during axon formation
This article is protected by copyright. All rights reserved. (Source: Journal of Neurobiology)
Source: Journal of Neurobiology - November 1, 2017 Category: Neurology Authors: Santiago Quiroga, Mariano Bisbal, Alfredo C áceres Tags: Review Article Source Type: research
