The axonal endoplasmic reticulum: One organelle —many functions in development, maintenance, and plasticity

We describe the interactions between the ER and endosomes, mitochondria, and synaptic vesicles. Finally, we analyze available proteomic data of axonal preparations to reveal the dynamic functionality of the ER in axons during development. We suggest that the dynamic proteome and a validated axonal interactome, together with state‐of‐the‐art methodologies, may provide interesting research avenues in axon physiology that may extend to pathology and regeneration. © 2017 Wiley Periodicals, Inc. Develop Neurobiol, 2017
Source: Journal of Neurobiology - Category: Neurology Authors: Tags: Review Article Source Type: research