Vildagliptin reduces cardiac ischemic-reperfusion injury in obese orchiectomized rats
This study investigated the effects of testosterone and vildagliptin on cardiac function, arrhythmias and the infarct size in I/R heart of testosterone-deprived rats with obese insulin resistance. Orchiectomized (O) or sham operated (S) male Wistar rats were divided into 2 groups to receive normal diet (ND) or high-fat diet (HFD) for 12 weeks. Orchiectomized rats in each diet were divided to receive testosterone (2 mg/kg), vildagliptin (3 mg/kg) or the vehicle daily for 4 weeks. Then, I/R was performed by a 30-min left anterior descending coronary artery ligation, followed by a 120-min reperfusion. LV function, arrhythmia ...
Source: Journal of Endocrinology - September 12, 2016 Category: Endocrinology Authors: Pongkan, W., Pintana, H., Jaiwongkam, T., Kredphoo, S., Sivasinprasasn, S., Chattipakorn, S. C., Chattipakorn, N. Tags: Research Source Type: research
PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy
In conclusion, these novel findings of PAPP-A and its regulation by proinflammatory cytokines, as well as the comprehensive analysis of the IGF system regulation in HMCs, suggest a mechanism by which inflammatory states such as DN can impact IGF activity in the kidney. (Source: Journal of Endocrinology)
Source: Journal of Endocrinology - September 12, 2016 Category: Endocrinology Authors: Donegan, D., Bale, L. K., Conover, C. A. Tags: Research Source Type: research
Rapid phenotyping of knockout mice to identify genetic determinants of bone strength
The genetic determinants of osteoporosis remain poorly understood, and there is a large unmet need for new treatments in our ageing society. Thus, new approaches for gene discovery in skeletal disease are required to complement the current genome-wide association studies in human populations. The International Knockout Mouse Consortium (IKMC) and the International Mouse Phenotyping Consortium (IMPC) provide such an opportunity. The IKMC generates knockout mice representing each of the known protein-coding genes in C57BL/6 mice and, as part of the IMPC initiative, the Origins of Bone and Cartilage Disease project identifies...
Source: Journal of Endocrinology - September 12, 2016 Category: Endocrinology Authors: Freudenthal, B., Logan, J., Sanger Institute Mouse Pipelines, Croucher, P. I., Williams, G. R., Bassett, J. H. D. Tags: Review Source Type: research
Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice
Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip+/–) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of Aip+/– mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12 months of ag...
Source: Journal of Endocrinology - September 11, 2016 Category: Endocrinology Authors: Lecoq, A.-L., Zizzari, P., Hage, M., Decourtye, L., Adam, C., Viengchareun, S., Veldhuis, J. D., Geoffroy, V., Lombes, M., Tolle, V., Guillou, A., Karhu, A., Kappeler, L., Chanson, P., Kamenicky, P. Tags: Research Source Type: research
Decreased basal insulin secretion from pancreatic islets of pups in a rat model of maternal obesity
The objective is to study the effect of MO on in vitro insulin secretion and pancreatic cellular population in offspring. We hypothesize that a harmful antenatal metabolic environment due to MO diminishes the basal glucose-responsive secretory function of pancreatic beta cells in offspring. Mothers were fed a control (C) or high-fat diet from weaning through pregnancy (120 days) and lactation. At postnatal days (PNDs) 36 and 110, pups were killed, peripheral blood was collected and pancreatic islets were isolated. Basal insulin secretion was measured in vitro in islets for 60 min. It was found that blood insulin, glucose a...
Source: Journal of Endocrinology - September 5, 2016 Category: Endocrinology Authors: Zambrano, E., Sosa-Larios, T., Calzada, L., Ibanez, C. A., Mendoza-Rodriguez, C. A., Morales, A., Morimoto, S. Tags: Research Source Type: research
