PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy

In conclusion, these novel findings of PAPP-A and its regulation by proinflammatory cytokines, as well as the comprehensive analysis of the IGF system regulation in HMCs, suggest a mechanism by which inflammatory states such as DN can impact IGF activity in the kidney.

Source: Journal of Endocrinology - September 12, 2016 Category: Endocrinology Authors: Donegan, D., Bale, L. K., Conover, C. A. Tags: Research Source Type: research