Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse
This study uses novel phenotypic assays which when applied to the mdx mouse resemble recently used primary end points for DMD clinical trials. A measurable distinction between dystrophic and control mice was seen at early time points in vivo compared with invasive muscle studies performed ex vivo. These assays shed light on normal and pathological responses to muscular exertion and have significant mechanistic and translational implications for the fields of basic myology and neuromuscular therapeutics. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Song, Y., Rosenblum, S. T., Morales, L., Petrov, M., Greer, C., Globerman, S., Stedman, H. H. Tags: RESEARCH ARTICLE Source Type: research
Intermittent hypobaric hypoxia combined with aerobic exercise improves muscle morphofunctional recovery after eccentric exercise to exhaustion in trained rats
We present the effects of intermittent hypobaric hypoxia and exercise on recovery from eccentric exercise-induced muscle damage (EEIMD). Soleus muscles from trained rats were excised before (CTRL) and 1, 3, 7, and 14 days after a double session of EEIMD protocol. A recovery treatment consisting of one of the following protocols was applied 1 day after the EEIMD: passive normobaric recovery (PNR), a 4-h daily exposure to passive hypobaric hypoxia at 4,000 m (PHR), or hypobaric hypoxia exposure followed by aerobic exercise (AHR). EEIMD produced an increase in the percentage of abnormal fibers compared with CTRL, and it affec...
Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Rizo-Roca, D., Rios-Kristjansson, J. G., Nunez-Espinosa, C., Santos-Alves, E., Goncalves, I. O., Magalhaes, J., Ascensao, A., Pages, T., Viscor, G., Torrella, J. R. Tags: RESEARCH ARTICLE Source Type: research
Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy
This study utilized a rat synergist ablation model to integrate changes in single muscle fiber contractility, extracellular matrix composition, activation of important signaling pathways in muscle adaption, and corresponding changes in the muscle transcriptome to provide novel insight into the basic biological mechanisms of muscle fiber hypertrophy. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Mendias, C. L., Schwartz, A. J., Grekin, J. A., Gumucio, J. P., Sugg, K. B. Tags: RESEARCH ARTICLE Source Type: research
Muscle damage and inflammation during recovery from exercise
Unaccustomed exercise consisting of eccentric (i.e., lengthening) muscle contractions often results in muscle damage characterized by ultrastructural alterations in muscle tissue, clinical signs, and symptoms (e.g., reduced muscle strength and range of motion, increased muscle soreness and swelling, efflux of myocellular proteins). The time course of recovery following exercise-induced muscle damage depends on the extent of initial muscle damage, which in turn is influenced by the intensity and duration of exercise, joint angle/muscle length, and muscle groups used during exercise. The effects of these factors on muscle st...
Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Peake, J. M., Neubauer, O., Della Gatta, P. A., Nosaka, K. Tags: REVIEW Source Type: research
Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise
The complexity and redundancy of the endocrine pathways during recovery related to anabolic function in the body belie an oversimplistic approach to its study. The purpose of this review is to examine the role of resistance exercise (RE) on the recovery responses of three major anabolic hormones, testosterone, growth hormone(s), and insulin-like growth factor 1. Each hormone has a complexity related to differential pathways of action as well as interactions with binding proteins and receptor interactions. Testosterone is the primary anabolic hormone, and its concentration changes during the recovery period depending on the...
Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Kraemer, W. J., Ratamess, N. A., Nindl, B. C. Tags: REVIEW Source Type: research
