Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse

This study uses novel phenotypic assays which when applied to the mdx mouse resemble recently used primary end points for DMD clinical trials. A measurable distinction between dystrophic and control mice was seen at early time points in vivo compared with invasive muscle studies performed ex vivo. These assays shed light on normal and pathological responses to muscular exertion and have significant mechanistic and translational implications for the fields of basic myology and neuromuscular therapeutics.

Source: Journal of Applied Physiology - March 5, 2017 Category: Physiology Authors: Song, Y., Rosenblum, S. T., Morales, L., Petrov, M., Greer, C., Globerman, S., Stedman, H. H. Tags: RESEARCH ARTICLE Source Type: research