Rat supraspinatus tendon responds acutely and chronically to exercise
This study defines acute and chronic changes of MMP activity, mechanical properties, and histology of the rat supraspinatus tendon in response to beneficial exercise and proposes a mechanism by which acute responses translate to chronic adaptations.
NEW & NOTEWORTHY The line between beneficial exercise and overuse has not been elucidated. This study defines the acute and chronic temporal response to exercise of supraspinatus tendon in an in vivo model. We found that decreased matrix metalloproteinase activity and tendon mechanics after a single bout of exercise are followed by beneficial chronic adaptations of the tend...
Source: Journal of Applied Physiology - October 9, 2017 Category: Physiology Authors: Rooney, S. I., Torino, D. J., Baskin, R., Vafa, R. P., Kuntz, A. F., Soslowsky, L. J. Tags: RESEARCH ARTICLE Source Type: research
Automated full-range pressure-volume curves in mice and rats
In conclusion, the automated technique generated full-range PV curves that were equivalent or very close to those obtained with the classic method under physiological or severe pathological conditions. The automation facilitated some technical aspects of the procedure, eased its use across species, and helped derive a more accurate estimate of FRC in preclinical models of respiratory disease.
NEW & NOTEWORTHY Partial and full-range pressure-volume (PV) curves are frequently used to characterize lung disease models. Whereas automated techniques exist to construct partial PV curves, a manually operated approach is classi...
Source: Journal of Applied Physiology - October 9, 2017 Category: Physiology Authors: Robichaud, A., Fereydoonzad, L., Limjunyawong, N., Rabold, R., Allard, B., Benedetti, A., Martin, J. G., Mitzner, W. Tags: INNOVATIVE METHODOLOGY Source Type: research
In vivo assessment of regional mechanics post-myocardial infarction: A focus on the road ahead
Cardiovascular disease, particularly the occurrence of myocardial infarction (MI), remains a leading cause of morbidity and mortality (Go et al., Circulation 127: e6–e245, 2013; Go et al. Circulation 129: e28–e292, 2014). There is growing recognition that a key factor for post-MI outcomes is adverse remodeling and changes in the regional structure, composition, and mechanical properties of the MI region itself. However, in vivo assessment of regional mechanics post-MI can be confounded by the species, temporal aspects of MI healing, as well as size, location, and extent of infarction across myocardial wall. Mor...
Source: Journal of Applied Physiology - October 9, 2017 Category: Physiology Authors: Romito, E., Shazly, T., Spinale, F. G. Tags: SYNTHESIS REVIEW Source Type: research
In obese mice, exercise training increases 11{beta}-HSD1 expression, contributing to glucocorticoid activation and suppression of pulmonary inflammation
This study aims to examine whether exercise training affects obesity-associated pulmonary inflammation by regulating local GC synthesis or metabolism. We found that sedentary obese (ob/ob) mice exhibited increased levels of interleukin (IL)-1β, IL-18, monocyte chemotactic protein (MCP)-1, and leukocyte infiltration in lung tissues compared with lean mice, which was alleviated by 6 wk of exercise training. Pulmonary corticosterone levels were decreased in ob/ob mice. Exercise training increased pulmonary corticosterone levels in both lean and ob/ob mice. Pulmonary corticosterone levels were negatively correlated with I...
Source: Journal of Applied Physiology - October 1, 2017 Category: Physiology Authors: Du, S.-F., Yu, Q., Chuan, K., Ye, C.-L., He, Z.-J., Liu, S.-J., Zhu, X.-Y., Liu, Y.-J. Tags: RESEARCH ARTICLE Source Type: research
Relationship between exercise volume and muscle protein synthesis in a rat model of resistance exercise
Resistance exercise (RE) volume is recognized as an important factor that stimulates muscle protein synthesis (MPS) and is considered, at least in part, to be involved in the mammalian target of rapamycin complex 1 (mTORC1)-associated signaling. However, the effects of relatively high-volume RE on mTORC1 and MPS remain unclear. In the present study, we used an animal model of RE to investigate the relationship between RE volume and MPS. Male Sprague-Dawley rats were subjected to RE, and muscle samples were obtained 6 h after performing 1, 3, 5, 10, or 20 sets of RE. Although 1 set of RE did not increase MPS [measured by th...
Source: Journal of Applied Physiology - October 1, 2017 Category: Physiology Authors: Ogasawara, R., Arihara, Y., Takegaki, J., Nakazato, K., Ishii, N. Tags: RESEARCH ARTICLE Source Type: research
Treating fructose-induced metabolic changes in mice with high-intensity interval training: insights in the liver, white adipose tissue, and skeletal muscle
In conclusion, in mice fed a fructose diet, HIIT improved body mass, blood pressure, glucose metabolism, and plasma triglycerides. Liver, WAT, and skeletal muscle were positively modulated by HIIT, indicating HIIT as a coadjutant treatment for diseases affecting these tissues.
NEW & NOTEWORTHY We investigated the effects of high-intensity interval training (HIIT) in mice fed a fructose-rich diet and the resulting severe negative effect on the liver, white adipose tissue (WAT), and skeletal muscle, which reduced the expression of fibronectin type III domain containing 5 (FNDC5, irisin) and PGC1α and, consequently,...
Source: Journal of Applied Physiology - October 1, 2017 Category: Physiology Authors: Motta, V. F., Bargut, T. L., Aguila, M. B., Mandarim-de-Lacerda, C. A. Tags: RESEARCH ARTICLE Source Type: research
Reply to Pettitt and Jamnicks letter in reference to: Measurement of the maximum oxygen uptake VO2max: VO2peak is no longer acceptable
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Poole, D. C., Jones, A. M. Tags: LETTERS TO THE EDITOR Source Type: research
Commentary on "Measurement of the maximum oxygen uptake VO2max: VO2peak is no longer acceptable"
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Pettitt, R. W., Jamnick, N. A. Tags: LETTERS TO THE EDITOR Source Type: research
Last Word on Point:Counterpoint
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Billman, G. E. Tags: POINT:COUNTERPOINT Source Type: research
Point:Counterpoint
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Flannery, D., Howden, E. J., La Gerche, A., Hughson, R. L., Leicht, A. S., Boullosa, D. A., Hautala, A. J., Zuo, L., He, F. Tags: POINT:COUNTERPOINT Source Type: research
Rebuttal from Billman on Point:Counterpoint: Exercise training-induced bradycardia
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Billman, G. E. Tags: POINT:COUNTERPOINT Source Type: research
Rebuttal from Boyett et al.
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Boyett, M. R., Wang, Y., Nakao, S., Ariyaratnam, J., Hart, G., Monfredi, O., DSouza, A. Tags: POINT:COUNTERPOINT Source Type: research
Counterpoint: Exercise training-induced bradycardia: the case for enhanced parasympathetic regulation
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Billman, G. E. Tags: POINT:COUNTERPOINT Source Type: research
Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function
(Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Boyett, M. R., Wang, Y., Nakao, S., Ariyaratnam, J., Hart, G., Monfredi, O., DSouza, A. Tags: POINT:COUNTERPOINT Source Type: research
