The cost-utility of stepped-care algorithms according to depression guideline recommendations – results of a state-transition model analysis
Major Depressive Disorder (MDD) diminishes quality of life and is associated with functional impairment, which has a tremendous impact on individuals, their relatives and society. In view of its high prevalence, MDD is costly from both a health care and a societal perspective (Ferrari et al, 2013; Chisholm et al, 2016). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Jolanda A.C. Meeuwissen, Talitha L. Feenstra, Filip Smit, Matthijs Blankers, Jan Spijker, Claudi L.H. Bockting, Anton J.L.M. van Balkom, Erik Buskens Tags: Research paper Source Type: research
Daytime Midpoint as a Digital Biomarker for Chronotype in Bipolar Disorder
Sleep disturbance is a pervasive and persistent phenomenon in bipolar disorder (BD), experienced by between 70-99% of BD patients (Harvey, Talbot,& Gershon, 2009). Abnormalities in sleep quality, as well as circadian rhythm irregularities, may be markers of current or imminent manic or depressive episodes (Cretu, Culver, Goffin, Shah,& Ketter, 2016; Gershon et al., 2017; Perlman, Johnson,& Mellman, 2006), or future positive or negative affect (Kaufmann, Gershon, Eyler,& Depp, 2016), and therefore are important markers for monitoring BD course and treatment progress. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Christopher N. Kaufmann, Anda Gershon, Colin A. Depp, Shefali Miller, Jamie M. Zeitzer, Terence A. Ketter Tags: Research paper Source Type: research
Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample.
Depression in older adults is a heterogeneous disorder with complex and multiple pathogenic mechanisms. Many studies have explored the vascular component of depression in older adults (Aizenstein et al., 2016). In contrast, few studies on the basis of the neurotrophin hypothesis, which is one of the main hypotheses of adult depression at the present day, have been conducted in older persons with depression. These few studies focused mostly on peripheral measurements of neurotrophins (Hashizume et al., 2015). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Paula Villela Nunes, Camila Fernandes Nascimento, Helena Kyunghee Kim, Ana Cristina Andreazza, Helena Paula Brentani, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Ricardo Nitrin Tags: Research paper Source Type: research
Naturally absorbed polyunsaturated fatty acids, lithium, and suicide-related behaviors: a case-controlled study
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (omega-3 fatty acids) have been reported to be effective for depression (Grosso et al., 2016; Sarris et al., 2016; Hallahan et al., 2016; Bloch and Hannestad, 2012; Lin et al., 2010), with studies favoring EPA rather than DHA as more effective (Sarris et al., 2016; Hallahan et al., 2016; Martins, 2009). However, the effects of omega-3 fatty acids on suicide appear to be inc onclusive (Pompili et al., 2017) because large epidemiological studies (Poudel-Tandukar et al., 2011; Tsai et al., 2014) have shown no supportive evidence for the association between ...
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Keiko Kurosawa, Takeshi Terao, Masayuki Kanehisa, Ippei Shiotsuki, Nobuyoshi Ishii, Ryuichi Takenaka, Teruo Sakamoto, Takehisa Matsukawa, Kazuhito Yokoyama, Shuntaro Ando, Atsushi Nishida, Yutaka Matsuoka Tags: Research paper Source Type: research
Habenular Connectivity May Predict Treatment Response in Depressed Psychiatric Inpatients
The habenula (Hb) is a diencephalic structure bilaterally positioned on either side of the third ventricle. It is composed of paired nuclei —medial and lateral—which differ in several characteristics including afferent/efferent connectivity (Klemm, 2004) and transcriptome (Lein et al., 2007). The nuclei receive inputs largely through the stria medullaris from the limbic-forebrain and basal ganglia and they project their output th rough the fasciculus retroflexus to several brainstem nuclei (Bianco and Wilson, 2009; Hikosaka et al., 2008; Omelchenko et al., 2009; Sesack and Grace, 2010). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Savannah N. Gosnell, Kaylah N. Curtis, Kenia Velasquez, J. Christopher Fowler, Alok Madan, Wayne Goodman, Ramiro Salas Tags: Research paper Source Type: research
Older Men with Bipolar Disorder Diagnosed in Early and Later Life: Physical Health Morbidity and General Hospital Service Use
Bipolar disorder (BD) is a disabling episodic mental health disorder that is associated with increased morbidity and premature mortality (Crump et al., 2013). This excess morbidity and mortality not only persists but might become more pronounced in old age (Almeida et al., 2016b), raising concerns about the potential impact of BD on health services as the population ages. The Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE) found that 96% of 482 participants had at least one other medical comorbidity, with cardiometabolic diseases becoming more prevalent with increa...
Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Osvaldo P. Almeida, Graeme J. Hankey, Bu B. Yeap, Jonathan Golledge, Leon Flicker Source Type: research
Depressive vulnerability in women with Alzheimer's disease: Relationship with personality traits and abnormal personality dimensions
Personality changes in AD have been documented in the literature and may constitute a useful early clinical marker of Dementia (e.g., Cipriani, Borin, Del Debbio,& Di Fiorino, 2015; Duberstein et al., 2010; Duchek et al., 2007; Henriques-Calado, Duarte-Silva,& Sousa Ferreira, 2016; Pocnet, Rossier, Antonietti,& von Gunten, 2011, 2013; Wahlin& Byrne, 2011). Within this field, the most robust and validated personality evaluation measure is based on the Five-Factor Model of Personality. The overall common objective is to understand personality changes in Dementia by comparing the pre-morbid and current measurement, in retrosp...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Joana Henriques-Calado, Maria Eug énia Duarte-Silva, Ana Sousa Ferreira Tags: Research paper Source Type: research
The relation between empathy and depressive symptoms in a Dutch population sample
Impairments in social functioning are common in individuals with (sub)clinical levels of depression (Hirschfeld et al., 2000; Kessler et al., 2003), and may persist after remission of a depressive episode (Burcusa and Iacono, 2007). Social functioning impairments not only precede depression (Verboom et al., 2014), but also prevent the occurrence of positive interactions with others that might help mitigate stressful periods (Oshri et al., 2017). Enduring impairments in social functioning likely contribute to the recurrent and sometimes chronic nature of depression. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Elise C. Bennik, Bertus F. Jeronimus, Marije aan het Rot Source Type: research
Course of subthreshold depression into a depressive disorder and its risk factors
Subthreshold depression is generally considered present when individuals report clinically relevant depressive symptoms (i.e. depressed mood or loss of interest) but diagnostic criteria for a fully developed depressive disorder are not met (Rodr íguez et al., 2012). Population-based studies on subthreshold depression have come up with a wide range of prevalence rates (1.4-17.2%). This is probably due to varying definitions of subthreshold depression (i.e. requiring a varying number of symptoms and/or a different minimum duration of the sym ptoms), recency of the symptomatology (i.e. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Marlous Tuithof, Margreet ten Have, Saskia van Dorsselaer, Marloes Kleinjan, Aartjan Beekman, Ron de Graaf Tags: Research paper Source Type: research
Psychosocial Profiles of Adolescents from Dissolved Families: Differences in Depressive Symptoms in Emerging Adulthood
Family dissolution, caused by parental separation or divorce, is consistently associated with negative outcomes for young people (see meta-analyses Amato, 2001; Amato& Keith, 1991). Common among findings is increased risk for subsequent depression (Culpin, Heron, Araya, Melotti,& Joinson, 2013; Oldehinkel, Ormel, Veenstra, De Winter,& Verholst, 2008). However, a substantial proportion of individuals from dissolved families do not experience depressive symptoms, or symptom increases are transient or modest in effect (Kessler et al., 2010; Ruschena, Prior, Sanson,& Smart, 2005). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Laura Di Manno, Jacqui A. Macdonald, George J. Youssef, Keriann Little, Craig A. Olsson Source Type: research
Psychosocial factors associated with symptoms of depression, anxiety and stress among single mothers with young children: A population-based study
The trend of single parent households has increased substantially over the past few decades and is anticipated to rise (OECD, 2011). Approximately 20% of German families in 2013 with a dependent child were headed by a single parent compared to 14% in 1996 and over 90% of such households are fronted by mothers (Statistisches Bundesamt, 2013). Similar trends are also found in other neighbouring countries such as the United Kingdom and Scandinavia (Chzhen and Bradshaw, 2012). Poorer health outcomes among single parents compared to partnered parents have been demonstrated consistently in the literature, with significantly incr...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Linda A. Liang, Ursula Berger, Christian Brand Tags: Research paper Source Type: research
Depression and Chronic Diseases: Co-Occurrence and Communality of Risk Factors
Depression is an important public health problem affecting approximately 350 million people worldwide (Hyman et al., 2006). It was the fourth leading cause of disease burden in 2000 (Hyman et al., 2006) and it is projected that depression will become the second leading cause of burden of disease by 2030 (Mathers and Loncar, 2006). In low and middle income countries (LMICs) it is expected that the bu rden of depression will increase even faster due to rapid social transitions and increased prevalence of “western lifestyle” risk factors (Mathers and Loncar, 2006) and disability attributed to depression is predic...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Mojtaba Lotfaliany, Steven J. Bowe, Paul Kowal, Liliana Orellana, Michael Berk, Mohammadreza Mohebbi Tags: Research paper Source Type: research
The impact of COMT polymorphisms on cognition in Bipolar Disorder: a review
Cognitive dysfunctions across attention, memory, and executive function represent a core feature of Bipolar Disorder (BD), regardless of the mood state and persisting between active mood episodes (Grande et al., 2016), and they play an important role in the long term social functioning of patients with BD (Cardoso et al., 2015). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: A. Pigoni, M. Lazzaretti, G.M. Mandolini, G. Delvecchio, A.C. Altamura, J.C. Soares, P. Brambilla Tags: Mini review Source Type: research
Bipolar features in major depressive disorder: Results from the Iranian mental health survey (IranMHS)
Depressive disorders are associated with the highest burden of disease among the mental and substance use disorders (Whiteford et al., 2013). The burden of disease attributed to bipolar disorders is considerably lower, mainly due to the lower prevalence of bipolar disorders (Whiteford et al., 2013). However, the emerging concept of bipolar spectrum and the growing evidence suggesting a higher prevalence of bipolar disorders than previously assumed (Akiskal et al., 2000; Angst, 1998; Judd and Akiskal, 2003; Moreno et al., 2007; Scott et al., 2013; Zutshi et al., 2011), suggest that the current estimates of burden of disease...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Masoumeh Amin-Esmaeili, Abbas Motevalian, Afarin Rahimi-Movaghar, Ahmad Hajebi, Vandad Sharifi, Ramin Mojtabai, Shahrokh S Gudarzi Tags: Research paper Source Type: research
Passive and Mentally-Active Sedentary Behaviors and Incident Major Depressive Disorder: a 13-Year Cohort Study
Depression is a prevalent and debilitating disorder associated with considerable socio-occupational impairment (Pratt et al., 2016). Although evidence-based treatments have grown, the success of interventions and maintenance of treatment responses remains limited (Pybis et al., 2017). Thus, there is a need for improved understanding of factors associated with depression onset so that efficacious treatment strategies can be developed and therapeutic outcomes optimized. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Mats Hallgren, Neville Owen, Brendon Stubbs, Zangin Zeebari, Davy Vancampfort, Felipe Schuch, Rino Bellocco, David Dunstan, Ylva Trolle Lagerros Tags: Research paper Source Type: research
