The overlooked primary: bladder cancer metastases on dry bone. A study of the 20th century CAL Milano Cemetery Skeletal Collection
ConclusionsBladder carcinoma metastases were mostly mixed, exhibiting periosteal reactions, perforations of bone cortex, spongiosclerosis and coalescing porosity.SignificanceBladder carcinoma is rarely considered in the differential diagnosis of the primary organ. This study reports the macroscopic aspect of bone metastases in bladder carcinoma and may help anthropologists diagnose the condition in skeletons.LimitationsAbsence of evidence is not evidence of absence; some lesions may have been hidden from macroscopic observation and therefore missed.Further researchRadiographic analysis and comparison with other neoplasms s...
Source: International Journal of Paleopathology - October 26, 2018 Category: Pathology Source Type: research

Maintaining mobility after fracture: A biomechanical analysis of fracture consequences at the Roman Sites of Ancaster (UK) and Vagnari (Italy)
ConclusionsRegardless of how a fracture healed, individuals at Ancaster and Vagnari generally resumed mobility after trauma whenever possible.SignificanceThis research contributes information about injury recovery and suggests that resilient behaviors and persistent mobility may have been valued or required responses to fracture in the study communities. This work advises that impairment should not be inferred based solely on the appearance of lesions.LimitationsSite, sex, and age patterns in injury recovery are not evaluated due to sample size limitations.Suggestions for further researchBiomechanical assessments of post-t...
Source: International Journal of Paleopathology - October 22, 2018 Category: Pathology Source Type: research

Hyperostosis frontalis interna in ancient populations from the Carpathian Basin – A possible relationship between lifestyle and risk of development
ConclusionsIn addition to age and sex, other factors could be implicated in HFI development. The physiological effects of the pastoralist lifestyle and diet on insulin regulation could explain the increased risk of developing HFI in the 5th–8th and 10th-century populations.SignificanceThe study provides the first comprehensive dataset of HFI from different archaeological periods from the Carpathian Basin. It has implications for lifestyle and risk of HFI development in past populations.LimitationsThe archaeological periods are not equally represented.Suggestions for further researchIn order to better understand the etiol...
Source: International Journal of Paleopathology - October 18, 2018 Category: Pathology Source Type: research

Trauma in the upper limb of an Upper Paleolithic female from Caviglione cave (Liguria, Italy): Etiology and after-effects in bone biomechanical properties
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Tony ChevalierAbstractThe impact of injury on the health and activities of human foragers is of great interest for understanding the adaptability of past populations to their environments. For the Gravettian female of Caviglione 1, a violent blow has been suggested as the origin of the left radial fracture, and abnormal body asymmetry has been observed. Access to high resolution CT-scans of the upper limb allows us to address new etiologic considerations and assess the after-effects of trauma on bone biomechanical properties by...
Source: International Journal of Paleopathology - October 17, 2018 Category: Pathology Source Type: research

Hide and seek: Impacted maxillary and mandibular canines from the Roman period Croatia
ConclusionA case of non-syndrome impaction in which the lack of eruptive force in combination with the unfavorable position of the tooth bud might have resulted in multiple impacted teeth is presented.SignificanceCurrent clinical knowledge reports low frequency of this anomaly, with maxillary impaction occurring more often than mandibular. Furthermore, canine impaction is even more rarely reported in the archaeological material. The presented case is the only one from the archaeological setting with impaction present both in maxillae and mandible.LimitationsIn modern populations multiple impactions are often associated wit...
Source: International Journal of Paleopathology - October 13, 2018 Category: Pathology Source Type: research

Foot binding in a Ming dynasty cemetery near Xi’an, China
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Elizabeth Berger, Liping Yang, Wa YeAbstractThis paper describes the morphology of the feet of a population of elite women from the Ming dynasty (1368–1644 CE) in Shaanxi province. This is a social stratum, time, and place in which foot binding was practiced. Among a group of 31 skeletons exhumed from the cemetery, eight were women with well-preserved foot bones. Macroscopic examination revealed that half these women (4/8) had clearly altered foot bones: the metatarsal bones, and the few observable phalanges, were gracile and...
Source: International Journal of Paleopathology - October 8, 2018 Category: Pathology Source Type: research

Co-morbidity with hypertrophic osteoarthropathy: A possible Iron Age Sarmatian case from the Volga steppe of Russia
ConclusionsThe study stresses that co-morbidity is a key parameter when interpreting disease in past populations, particularly when the diagnosis involves hypertrophic osteoarthropathy.SignificanceThis is the first case of hypertrophic osteoarthropathy identified in Eurasian prehistoric populations. The research emphasises the significance of co-morbidity in the past.LimitationsThe diagnosis of co-morbid diseases in human remains is extremely complex and the conditions were identified as most probable by a process of elimination.Suggestions for further researchFurther studies should be dedicated to understanding co-morbidi...
Source: International Journal of Paleopathology - October 6, 2018 Category: Pathology Source Type: research

“Aged” autopsy gallstones simulating dry bone context: A morphological, histological and SEM-EDS analysis
ConclusionsAlthough identification of gallstones in archaeological contexts can be challenging, familiarity with morphological, histological, and elemental variation can assist researchers in the field and laboratory.SignificanceIdentifying gallstones in archaeological populations will assist researchers in estimating their frequency in the past and the environmental, cultural, and biological conditions leading to their presence.LimitationsSmall sample size derived from a modern and limited autopsy population may minimize the types and degree of variation present in the past. Effects of climate, soil, and taphonomy were no...
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

Two findings of gallstones in archaeological mummies from Colombia
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Felipe Cárdenas-Arroyo, Maria Cristina MartinaAbstractResults involving the analysis of gallstones found in two pre-Hispanic Colombian mummies are presented. By applying SEM, X-ray diffraction (XRD), sectioning, and CT-scan Hounsfield Units, we were able to identify these choleliths as mainly formed by cholesterol. The number of reports on gallstones in archaeological human remains from South America is very small, making these two cases an important addition to what little is known about ancient gallstone disease on the conti...
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

SCJ osteoarthritis: The significance of joint surface location for diagnosis
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Melissa Dobson, Tony WaldronAbstractAn evaluation of the method used to diagnose sternoclavicular joint (SCJ) osteoarthritis (OA) in skeletal remains is presented, with particular attention given to the anatomy of the joint. The current palaeopathological diagnostic criteria used to identify SCJ OA were found to be appropriate for both the sternal and clavicular surfaces of the SCJ, with eburnation indicating perforation of the intra-articular disc and advanced disease. Eburnation was found to occur rarely in the SCJ, and if us...
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

The Comparative Palaeopathology of Males and Females in English Medieval Skeletal Samples in a Social Context, Clare Duncan (2016). BAR British Series 629.
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Tina Jakob (Source: International Journal of Paleopathology)
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

A Possible case of Facio-Auriculo-Vertebral sequence (FAVs) in an adult female from medieval Iceland (13th–16th Century)
ConclusionsThis individual presents with anomalous craniofacial asymmetry consistent with a clinical diagnosis of FAVs.SignificanceThis paper offers a visually distinct case of an under-represented and under-documented congenital condition for future identification within paleopathology.LimitationsInfra-cranial skeletal manifestations of FAVs would strengthen this possible diagnosis, but at this time it is not possible to definitively link the cranium and mandible of HFE-A-34 to any of the infra-cranial remains excavated from Haffjarðarey.Suggestions for further researchIn addition to further clarifying the variable natur...
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

Vertebral infection in a male individual buried in the monastic cemetery (Cemetery 2) at Ghazali (ca. 670–1270 CE), northern Sudan
ConclusionsTuberculosis is the most probable etiology for the lesions observed. This assessment is based on the morphology of the lesions in conjunction with the known confined living quarters at Ghazali and the presence of tuberculosis vectors (i.e. cattle) in the region.Contributions to knowledge/originality/valueThis brief communication contributes original data documenting the presence of tubercular lesions in a monk buried at the Christian Nubian monastery of Ghazali. On a broader level this study contributes to regional and temporal paleopathological dialogues regarding interactions with pathogens in Christian Nubian...
Source: International Journal of Paleopathology - October 5, 2018 Category: Pathology Source Type: research

A circular depression at the spinoglenoid notch of a prehistoric Andean scapula: Plausible evidence of suprascapular nerve entrapment by a paralabral cyst
Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Anne R. Titelbaum, Bebel Ibarra Asencios, Bronwyn E. McNeilAbstractWhile intraosseous cysts have been described in the paleopathological literature, it is rare to find reports concerning effects of soft tissue cysts, although they are relatively common in clinical contexts. Here we present plausible evidence of an extraosseous paralabral cyst, seen in an adult scapula from a Late Intermediate period commingled tomb (ca. AD 1200) at the northern highland site of Marcajirca, Ancash, Peru. The scapula demonstrated a smooth-sided c...
Source: International Journal of Paleopathology - September 21, 2018 Category: Pathology Source Type: research

Possible case of pressure resorption associated with osteoarthritis in human skeletal remains from ancient China
We examined the osteoarthritic distal femora of an individual from Ancient North China, ca. 475-221 BCE. The standard signs of osteoarthritis, marginal lipping and extensive eburnation, were observed in the patellofemoral compartment of the knee joint. In addition however were bilateral pressure-caused fossae on the extra-articular anterior surfaces of the distal femora 10 mm proximal to the large osteophytes at the apex of the patellar surfaces. Anatomy and possible pathogenesis of knee arthritis are explored in order to come to a tentative aetiology of the extra-articular lesions. These lesions are suggested to be a ne...
Source: International Journal of Paleopathology - September 21, 2018 Category: Pathology Source Type: research